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The administration of sedatives may present several challenges for critical care nurses. Evidence-based practice requires critical care nurses to remain up to date with developments in sedation management and ensure safe and effective use of sedative agents in their practice. Dexmedetomidine is a sedative drug that has been increasingly used in the intensive care setting in recent years. This article provides an overview of the pharmacological properties of dexmedetomidine and discusses nurses' responsibilities in caring for patients receiving dexmedetomidine infusion. [ABSTRACT FROM AUTHOR]

This article explores the efforts of scientists to study the protein targets of anesthetics. Richard Olsen, a pharmacologist at the University of California in Los Angeles, identified several aspects of the anesthetized state, including amnesia, unconsciousness and sedation. Olsen attributed the effects to the anesthetic interacting with a different protein. Data from some researchers showed the binding of anesthetics such as propofol and desfiurane to their targets.

The article focuses on a research by scientists Nicholas P. Franks and Alex S. Evers regarding the information on the activity of the next-generation intravenous drug propofol by researching on its binding site at its protein target gamma amino butyric acid (GABA) receptor.