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This paper is a short note about the current status of bioactivity testing involving plant material. A generalised science overview is provided, with two South African provinces, viz. Cape Town and KwaZulu-Natal, used as examples to explain the discrepancies often encountered in bioactivity testing outcomes. (All of the views provided in this paper are those of the author. Only some of the information provided, I (the author) had obtained while based in the School of Life Sciences at the University of KwaZulu-Natal (Westville campus) in 2014). [ABSTRACT FROM AUTHOR]