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Nowadays, Artificial intelligence (AI), combined with the digitalization of healthcare, can lead to substantial improvements in Patient Care, Disease Management, Hospital Administration, and supply chain effectiveness. Among predictive analytics tools, time series forecasting represents a central task to support healthcare management in terms of bookings and medical services predictions. In this context, the development of flexible frameworks to provide robust and reliable predictions became a central point in this healthcare innovation process. This paper presents and discusses a multi-source time series fusion and forecasting framework relying on Deep Learning. By combining weather, air-quality and medical bookings time series through a feature compression stage which preserves temporal patterns, the prediction is provided through a flexible ensemble technique based on machine learning models and a hybrid neural network. The proposed system is able to predict the number of bookings related to a specific medical examination for a 7-days horizon period. To assess the proposed approach's effectiveness, we rely on time series extracted from a real dataset of administrative e-health records provided by the Campania Region health department, in Italy. • We propose a multi-source time-series fusion methodology relying on Deep Learning. • We design a robust framework for daily 7-days-horizon predictions. • We assess the proposed approach on a real medical bookings dataset. [ABSTRACT FROM AUTHOR]