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With a view to providing general Storey Loss Functions (SLFs) for existing reinforced concrete (RC) residential buildings in Italy, this paper layouts the procedure and the development of SLFs for different residential building typologies, using post-earthquake observational damage data of the 2009 L'Aquila earthquake. To do so, the addressed building typologies and the cost ratios, with respect to the total construction cost, for structural and non-structural elements were defined according to the Italian price bulletin of building typologies, using the current average construction cost per square meter. Fragility models available in the literature, which had been specifically calibrated for structural and non-structural elements commonly found in Italian and Mediterranean RC buildings, were employed and the assumed repair costs were the ones incurred for repairing the buildings damaged during the 2009 L'Aquila earthquake. The proposed SLFs were then employed to perform loss assessment on a representative portfolio of Italian existing masonry-infilled RC residential buildings, showing the consistency of the results with respect to available research studies. The outcomes therefore denote how the proposed SLFs can be a useful tool as an alternative to the simplified conservative loss assessment guidelines currently employed in Italy, with a view to planning risk mitigation measurements both at a regional and single-building level. [ABSTRACT FROM AUTHOR]