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This handbook reviews the clinical applications of stem cell-based therapy. The book covers the clinical applications of stem cells in cardiovascular diseases, neurological and ocular diseases, pediatrics, and the role of cancer stem cell-derived exosomal microRNA payload in lung cancer. The chapter reviews emerging stem cell therapy and tissue engineering approaches in neurodegenerative diseases. The book further examines the applications of stem cells in various fields of dentistry, and for the regeneration of oral and non-oral tissues. The chapters also explore the application of 3D bioprinting in conjunction with bone marrow mesenchymal stem cells for the treatment of bone defects and state-of-the-art technology for bone and cartilage regeneration using mesenchymal stem cells. The book presents stem cell-based therapy against renal, pancreatic, and kidney diseases and examines the advantages of a novel hepatic stem for cirrhotic liver repair and regeneration. Lastly, the book provides methodological and procedural advancements in stem cell-based therapy, including the applications of single-cell sequencing in stem cell research. This handbook is a major one-stop reference for researchers working in regenerative medicine, cellular pharmacology, stem cell research in general, and those involved in specific areas of adult stem cells as well as embryonic and induced pluripotent stem cells. ​

Adolescent sexuality and gynecologic care of young patients are topics which make most clinicians uncomfortable. This is due to a lack of knowledge and training in many circumstances. Assumptions based upon knowledge of adult gynecology alone may be hazardous for pediatric and adolescent patients. These children and young women often do not have access to specialists who are able and willing to care for their gynecologic issues at an appropriate level. The primary care setting is often the most comfortable venue for a number of these patients. The concept for this book was to provide a reference for primary care providers without highly specialized gynecology textbooks, just to focus on what providers tackle on a daily basis. The first edition was well received and the feedback was good. In the 10 years since the first edition was published, our knowledge has improved and many new methods, medications and devices were added to daily practice. Those changes prompted the Editors to provide an updated version of the book, while keeping its essence intact.