1. Immunopathology in the brain of mice following vertical transmission of Coxsackievirus B4.
- Author
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Jmii, Habib, Halouani, Aymen, Abdeli, Mariem, Aouni, Mahjoub, Fisson, Sylvain, and Jaïdane, Hela
- Subjects
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COXSACKIEVIRUS diseases , *CENTRAL nervous system , *IMMUNOPATHOLOGY , *BRAIN , *T cells , *COXSACKIEVIRUSES - Abstract
Coxsackie B viruses (CV–B) are associated with several central nervous system (CNS) disorders. These viruses are predominantly transmitted by fecal-oral route but vertical transmission can also occur. This work attempted to study the immune response ensuing vertical transmission of CV-B to the brain, and its eventual implementation in the brain pathogenesis. To this end, pregnant Swiss albino mice were inoculated with CV-B4 E2 or with sterile medium for control animals. At different ages after birth, brains were collected and analyzed for virus infection, histopathological changes and immune response. Infectious particles were detected in offspring's brain which demonstrates vertical transmission of the virus. This infection is persistent since the long lasting detection of viral RNA in offspring's brain. Some pathological signs including meningitis, edema and accumulation of inflammatory cells within and surrounding the inflammatory areas were observed. Immunoflorescence staining unveiled the presence of T lymphocytes and microgliosis in the sites of lesion for a long period after birth. Multiplex cytokines measurement upon supernatants of in vitro mixed brain cells and extracted mononuclear cells from offspring's brain has demonstrated an elevated secretion of the pro-inflammatory cytokines TNFα, IL-6 and IFNα and the chemokines RANTES and MCP-1. Hence, vertical transmission of CV-B4 and its persistence within offspring's brain can lead to pathological features linked to increased and sustained immune response. • Coxsackievirus B4 infects and persists in the brain of mice following its vertical transmission. • This infection gives histopathological abnormalities in the brain of infected offspring. • Mixed brain cells and brain mononuclear cells showed an elevated secretion of pro-inflammatory cytokines. • Signs of inflammation including microgliosis and inflammatory cells infiltration detected in the pathological areas. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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