1. A tumor-associated macrophages related model for predicting biochemical recurrence and tumor immune environment in prostate cancer.
- Author
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Chen, Jia-Yin, Huang, Xu-Yun, Lin, Fei, You, Qi, Xue, Yu-Ting, Lin, Bin, Zheng, Qing-Shui, Wei, Yong, Xue, Xue-Yi, Li, Xiao-Dong, Chen, Dong-Ning, and Xu, Ning
- Subjects
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PROGRAMMED cell death 1 receptors , *TUMOR microenvironment , *PROSTATE cancer , *MOLECULAR clusters , *BIOCHEMICAL models , *DISEASE relapse , *OLDER men - Abstract
To identify tumor-associated macrophages (TAMs) related molecular subtypes and develop a TAMs related prognostic model for prostate cancer (PCa). Consensus clustering analysis was used to identify TAMs related molecular clusters. A TAMs related prognostic model was developed using univariate and multivariate Cox analysis. Three TAMs related molecular clusters were identified and were confirmed to be associated with prognosis, clinicopathological characteristics, PD-L1 expression levels and tumor microenvironment. A TAMs related prognostic model was constructed. Patients in low-risk group all showed a more appreciable biochemical recurrence-free survival (BCRFS) than patients in high-risk group in train cohort, test cohort, entire TCGA cohort and validation cohort. SLC26A3 attenuated progression of PCa and prevented macrophage polarizing to TAMs phenotype, which was initially verified. We successfully identified molecular clusters related to TAMs. Additionally, we developed a prognostic model involving TAMs that exhibits excellent predictive performance for biochemical recurrence-free survival in PCa. • We identified three TAMs related molecular clusters related to tumor immune microenvironment and clinicopathologic features. • We developed a TAMs related prognostic model with excellent predictive performance for BCRFS of PCa patients. • These findings would provide a novel insight for mechanism by which TAMs infiltration regulated PCa progression in TME. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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