1. Bio-electrochemical degradation of carbamazepine (CBZ): A comprehensive study on effectiveness, degradation pathway, and toxicological assessment.
- Author
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Sathya, Pavithra Muthukumar, Mohan, Harshavardhan, Park, Jung-Hee, Seralathan, Kamala-Kannan, Cho, Min, and Oh, Byung-Taek
- Subjects
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CARBAMAZEPINE , *LIQUID chromatography-mass spectrometry , *WASTEWATER treatment , *ESCHERICHIA coli , *RESEARCH personnel - Abstract
Recent attention on the detrimental effects of pharmaceutically active compounds (PhACs) in natural water has spurred researchers to develop advanced wastewater treatment methods. Carbamazepine (CBZ), a widely recognized anticonvulsant, has often been a primary focus in numerous studies due to its prevalence and resistance to breaking down. This study aims to explore the effectiveness of a bio-electrochemical system in breaking down CBZ in polluted water and to assess the potential harmful effects of the treated wastewater. The results revealed bio-electro degradation process demonstrated a collaborative effect, achieving the highest CBZ degradation compared to electrodegradation and biodegradation techniques. Notably, a maximum CBZ degradation efficiency of 92.01% was attained using the bio-electrochemical system under specific conditions: Initial CBZ concentration of 60 mg/L, pH level at 7, 0.5% (v/v) inoculum dose, and an applied potential of 10 mV. The degradation pathway established by identifying intermediate products via High-Performance Liquid Chromatography-Mass Spectrometry, revealed the complete breakdown of CBZ without any toxic intermediates or end products. This finding was further validated through in vitro and in vivo toxicity assays, confirming the absence of harmful remnants after the degradation process. [Display omitted] • CBZ was degraded through bio-electrochemical system employing the strain Escherichia coli AD-15. • Highest CBZ degradation of 92.01% was achieved in BES. • Specific conditions included, CBZ concentration: 60 mg/L; pH: 7; inoculum dose: 0.5% (v/v); & applied potential: 10 mV. • The degradation pathway showed complete mineralization of CBZ. • BES treatment exhibited minimal toxicity confirming their environmental application. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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