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[Display omitted] Transition metal oxides have been acknowledged for their exceptional water splitting capabilities in alkaline electrolytes, however, their catalytic activity is limited by low conductivity. The introduction of sulfur (S) into nickel molybdate (NiMoO 4) at room temperature leads to the formation of sulfur-doped NiMoO 4 (S-NiMoO 4), thereby significantly enhancing the conductivity and facilitating electron transfer in NiMoO 4. Furthermore, the introduction of S effectively modulates the electron density state of NiMoO 4 and facilitates the formation of highly active catalytic sites characterized by a significantly reduced hydrogen absorption Gibbs free energy (ΔG H*) value of −0.09 eV. The electrocatalyst S-NiMoO 4 exhibits remarkable catalytic performance in promoting the hydrogen evolution reaction (HER), displaying a significantly reduced overpotential of 84 mV at a current density of 10 mA cm−2 and maintaining excellent durability at 68 mA cm−2 for 10 h (h). Furthermore, by utilizing the anodic sulfide oxidation reaction (SOR) instead of the sluggish oxygen evolution reaction (OER), the assembled electrolyzer employing S-NiMoO 4 as both the cathode and anode need merely 0.8 V to achieve 105 mA cm−2, while simultaneously producing hydrogen gas (H 2) and S monomer. This work paves the way for improving electron transfer and activating active sites of metal oxides, thereby enhancing their HER activity. [ABSTRACT FROM AUTHOR]

Mo-doping is introduced to synchronously improve the electro catalytic activity and anti-chlorine corrosion of Ni 3 s 2 toward the efficient overall seawater splitting, thanks to the enhanced binding with *OH but the weakened one with *CL. [Display omitted] Designing highly active electrocatalysts that can resist chloride ion (Cl-) corrosion during seawater electrolysis is still a challenge. Here, Mo-doping is introduced to synchronously improve the electrocatalytic activity and anti-chlorine corrosion of Ni 3 S 2 toward the efficient overall seawater splitting. With commercial nickel-molybdenum foam (NMF) as the reactive substrates, Mo-doped Ni 3 S 2 columnar arrays (Mo-Ni 3 S 2 /NMF) are fabricated via a one-step hydrothermal process, which expose abundant active sites with the ameliorated surface electronic configurations toward the enhanced binding with *OH (* denotes an active site) but the weakened one with *Cl. As expected, they afford the excellent bi-functionality for both oxygen and hydrogen evolution reactions (OER and HER), with the remarkably improved anti-corrosion to Cl- at anode as compared to pristine Ni 3 S 2. In alkaline mimic seawater (1.0 M NaOH + 0.5 M NaCl), Mo-Ni 3 S 2 /NMF requires 330 mV (for OER) and 209 mV (for HER) overpotentials at the current density of ±100 mA cm−2, and a low cell voltage of 1.52 V at 10 mA cm−2 for overall seawater splitting. This work highlights a feasible strategy to explore highly active and stable electrocatalysts for sustainable H 2 production. [ABSTRACT FROM AUTHOR]

[Display omitted] • An H4R target pathway model for high-throughput screening tests was developed. • Cryptotanshinone was a new H4R non-competitive antagonist. • Cryptotanshinone interacts with H4R at a novel allosteric binding site. Histamine 4 receptor (H4R), the most recently identified subtype of histamine receptor, primarily induces inflammatory reactions upon activation. Several H4R antagonists have been developed for the treatment of inflammatory bowel disease (IBD) and atopic dermatitis (AD), but their use has been limited by adverse side effects, such as a short half-life and toxicity. Natural products, as an important source of anti-inflammatory agents, offer minimal side effects and reduced toxicity. This work aimed to identify novel H4R antagonists from natural products. An H4R target-pathway model deconvoluted downstream G i and MAPK signaling pathways was established utilizing cellular label-free integrative pharmacology (CLIP), on which 148 natural products were screened. Cryptotanshinone was identified as selective H4R antagonist, with an IC 50 value of 11.68 ± 1.30 μM, which was verified with Fluorescence Imaging Plate Reader (FLIPR) and Cellular Thermal Shift (CTS) assays. The kinetic binding profile revealed the noncompetitive antagonistic property of cryptotanshinone. Two allosteric binding sites of H4R were predicted using SiteMap, Fpocket and CavityPlus. Subsequent molecular docking and dynamics simulation indicated that cryptotanshinone interacts with H4R at a pocket formed by the outward interfaces between TM3/4/5, potentially representing a new allosteric binding site for H4R. Overall, this study introduced cryptotanshinone as a novel H4R antagonist, offering promise as a new hit for drug design of H4R antagonist. Additionally, this study provided a novel screening model for the discovery of H4R antagonists. [ABSTRACT FROM AUTHOR]

Constructing hierarchical structure is an effective approach to improve the activities of catalysts. Herein, a novel hierarchical structure of TiO 2 nanodots anchored on N-doped carbon nanotubes encapsulated Co nanoparticles (TiO 2 /Co@NCT) was synthesized by a simple pyrolysis method. Their catalytic performances were examined in the oxidative and light-assisted degradation of recalcitrant pollutants in the presence of the peroxymonosulfate (PMS). The Orange II removal efficiency within 15 min reached about 98.48% in TiO 2 /Co@NCT/PMS system. In this system, Co 0 is used to react with PMS to generate free radicals for the degradation of dyes. The carbon shell benefits the adsorption of dyes and prevents the catalysts from dissolving in the solution. Besides, under light irradiation, TiO 2 nanodots can be excited to generate photo-induced electrons, which can reduce inner Co 2+ to Co 0 in the degradation process, thus TiO 2 /Co@NCT exhabited high activity and outstanding stability in degradation process. The as-prepared TiO 2 /Co@NCT catalyst showed efficient degradation and superior stability, which would make it a great promise in practical applications for sewage treatment. [ABSTRACT FROM AUTHOR]