1. Identification of gluten T cell epitopes driving celiac disease.
- Author
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Chlubnová, Markéta, Christophersen, Asbjørn O., Sandve, Geir Kjetil F., Lundin, Knut E. A., Jahnsen, Jørgen, Dahal-Koirala, Shiva, and Sollid, Ludvig M.
- Subjects
- *
CELIAC disease , *EPITOPES , *GLUTEN , *GLUTELINS , *PEPTIDOMIMETICS , *T cells - Abstract
The article discusses a research study conducted to combine the knowledge of a distinct phenotype of gluten-reactive T cells and key features of known gluten epitopes for the discovery of unknown epitopes. It is noted that the research tested 42 wheat gluten–reactive T cell clones, isolated on the basis of distinct phenotype and with no reactivity to known epitopes, against synthetic peptides bioinformatically identified from a wheat gluten protein database.
- Published
- 2023
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