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The article focuses on a study which reveals that exogenous gluten drives T cell–B cell interactions that cause autoimmunity in celiac disease. It mentions that the gluten epitopes that are recognized by the CD4+ T cells uniformly contain negatively charged glutamate residues that are important for binding to the CeD-associated major histocompatibility complex (MHC) class II molecules.

The article discusses a research study conducted to combine the knowledge of a distinct phenotype of gluten-reactive T cells and key features of known gluten epitopes for the discovery of unknown epitopes. It is noted that the research tested 42 wheat gluten–reactive T cell clones, isolated on the basis of distinct phenotype and with no reactivity to known epitopes, against synthetic peptides bioinformatically identified from a wheat gluten protein database.