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Your search keyword '"López, Fernando"' showing total 11 results
Start Over Author "López, Fernando" Publication Year Range Last 10 years Publisher american chemical society
11 results on '"López, Fernando"'

10. Gold(I)-catalyzed intermolecular cycloaddition of allenamides with α,β-unsaturated hydrazones: efficient access to highly substituted cyclobutanes.

Author

Bernal-Albert P, Faustino H, Gimeno A, Asensio G, Mascareñas JL, and López F

Subjects
Catalysis, Combinatorial Chemistry Techniques, Cycloaddition Reaction, Cyclobutanes chemistry, Hydrazones chemistry, Molecular Structure, Stereoisomerism, Alkadienes chemistry, Cyclobutanes chemical synthesis, Gold chemistry, Hydrazones chemical synthesis
Abstract

α,β-Unsaturated N,N-dialkyl hydrazones undergo a mild [2 + 2] cycloaddition to allenamides when treated with a suitable gold catalyst. The method, which represents the first application of N,N-dialkyl hydrazones in gold catalysis, is compatible with a wide variety of substituents at the alkenyl moiety of the hydrazone component, proceeds with excellent levels of regio- and diastereoselectivity, and provides densely substituted cyclobutanes with good to excellent yields.

Published
2014
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11. Nickel-catalyzed intramolecular [3 + 2 + 2] cycloadditions of alkylidenecyclopropanes. A straightforward entry to fused 6,7,5-tricyclic systems.

Author

Saya L, Fernández I, López F, and Mascareñas JL

Subjects
Alkenes chemistry, Catalysis, Cyclization, Cycloaddition Reaction, Heterocyclic Compounds, 3-Ring chemistry, Molecular Structure, Stereoisomerism, Alkynes chemistry, Cyclopropanes chemistry, Heterocyclic Compounds, 3-Ring chemical synthesis, Nickel chemistry
Abstract

A highly diastereo- and chemoselective intramolecular nickel-catalyzed cycloaddition of alkene- and alkyne-tethered alkynylidenecyclopropanes is reported. The method constitutes the first fully intramolecular [3 + 2 + 2] alkylidenecyclopropropane cycloaddition occurring via a proximal cleavage of the cyclopropane and makes it possible to build relevant 6,7,5-tricyclic frameworks in a single-pot reaction. Importantly, the reaction outcome is highly dependent on the characteristics of the nickel ligands.

Published
2014
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