1. Molecular docking analysis of flavonoids with aldose reductase.
- Author
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Kannayiram K, Umapathy VR, Chamundeswari Y, Fathima JH, Govindan R, Palanisamy CP, Veeraraghavan VP, Jayaraman S, and Rajagopal P
- Abstract
Diabetes mellitus is a group of metabolic disorders that has risen to become the third most common cause in humans in recent years. The development of new bioactive substances from natural sources is a relatively new area. Flavonoids are believed to have a variety of beneficial properties in nature, including anti-inflammatory, antimicrobial, anticancer, antioxidant, neuroprotective, and anti-HIV properties. 15 naturally occurring flavonoids docked with the selected target aldose reductase. We report the optimal binding of Acumitin, Agathisflavone, Agehoustin B, and alpha-Toxicarol with aldose reductase for further consideration in drug discovery for T2DM., Competing Interests: None declared., (© 2022 Biomedical Informatics.)
- Published
- 2022
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