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• Management of a pandemic could be enhanced by a rational public health decision making process. • Decision Support Systems (DSS) can facilitate the exploration of pandemic-related questions. • A public health decision-making process could be formalized and embedded within a modular DSS. • A methodology for designing a modular DSS for public health decision-making is presented. • The modular DSS would include established data analytic methods such a data mining methods and DEA. The awareness of the occurrence of a new disease involves much uncertainty and the search for answers and also appropriate questions. In this paper we focus on the perspective of public health decision-makers. Typically, they would have a standard set of questions and supporting metrics that have been found in previous disease outbreaks to be useful in assessing the effectiveness of various 'solution' methods on the trajectory of the disease. There may be other relevant questions with which such public health domain experts may not be familiar and/or for which they are familiar but are not aware of methods for addressing such questions when there is limited data. Decision Support Systems (DSS) can be used to facilitate the exploration of established questions and some other relevant questions. Given an initial set of questions, the DSS designer should consider which sets of data analytic methods have the capabilities to adequately address. Some of these data analytic methods may also have the capability of addressing questions that could be of interest to the public health decision makers including researchers. In this paper we present a conceptual design for a relevant easy-to-construct DSS and an example of a multi-method DSS that is based on this conceptual design. Using publicly available data on the CoViD-19 pandemic, we illustrate benefits of the multi-method DSS in action. [ABSTRACT FROM AUTHOR]