8 results on '"Wang, Xuanbin"'
Search Results
2. Progress in clinical research on the integration of Chinese and Western medicines for treating primary liver cancer
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Liu, Kaiqi, Li, Hongliang, Duan, Jufeng, Chen, Xiaojing, Yu, Xiongjie, Wang, Xianhe, Liu, Ming, Li, Bei, Li, Minglun, Feng, Yibin, Cai, Xiaojun, and Wang, Xuanbin
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- 2021
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3. Hepatoprotection and hepatotoxicity of Heshouwu, a Chinese medicinal herb: Context of the paradoxical effect.
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Li, Hongliang, Wang, Xuanbin, Liu, Ying, Pan, Dongfeng, Wang, Ye, Yang, Nian, Xiang, Longchao, Cai, Xiaojun, and Feng, Yibin
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CHINESE medicine , *POLYGONUM multiflorum , *HEPATOTOXICOLOGY , *THERAPEUTICS , *FATTY liver , *DOSAGE forms of drugs - Abstract
Heshouwu ( Polygonum multiflorum Thunb.) has been a common Chinese medicine and a folk Taoist medicine for over a thousand years. There are two drug forms, Shengshouwu ( Polygoni Multiflori Radix ) and Zhiheshouwu ( Polygoni Multiflori Radix Prapaerata ) in the Chinese Pharmacopoeia. In this review, we retrieved articles with such keywords as Heshouwu , liver protection and liver toxicity in the databases of PubMed and the China National Knowledge Infrastructure (CNKI). Hepatoprotection and hepatotoxicity of Shengshouwu and Zhiheshouwu in vitro and in vivo , and their clinical settings and adverse drug reactions (ADR) were summarized, analyzed and critically reviewed. In bench research, both drug forms had effects against nonalcoholic fatty liver disease, oxidation, fibrosis, cirrhosis, and liver cancer. Clinically, Heshouwu was used for treating fatty liver disease (FLD), hyperlipidemia, cirrhosis and hepatitis B. In contrast, both drug forms could lead to drug-induced liver injury and even death in vitro , in vivo and in clinical settings. In addition, the active components of both drug forms had hepatic benefits and toxicity in interaction with emodin, physcion, and probably 2,3,5,4′-tetrahydroxy-stilbene-2-O-beta- d -glucoside (TSG). In conclusion, Heshouwu exhibited both hepatoprotection and hepatotoxicity. It is essential to evaluate the advantages and disadvantages when Heshouwu is in clinical use. [ABSTRACT FROM AUTHOR]
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- 2017
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4. Flavonoids and saponins: What have we got or missed?
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Wang, Xuanbin, Ma, Yan, Xu, Qihe, Shikov, Alexander N., Pozharitskaya, Olga N., Flisyuk, Elena V., Liu, Meifeng, Li, Hongliang, Vargas-Murga, Liliana, and Duez, Pierre
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• Flavonoids and saponins have drawn increased attention in the past decades. • Increased research links with oxidative stress- and inflammation-related diseases. • In vitro drug-like activities and molecular targets are abundantly reported. • In vivo and clinical data are often insufficient to support clinical recommendations. • Innovation is needed for understanding the true value of these compounds. Flavonoids and saponins are important bioactive compounds that have attracted wide research interests. This review aims to summarise the state of the art of the pharmacology, toxicology and clinical efficacy of these compounds. Data were retrieved from PubMed, Cochrane Library, Web of Science, Proquest, CNKI, Chongqing VIP, Wanfang, NPASS and HIT 2.0 databases. Meta-analysis and systematic reviews were evaluated following the PRISMA guideline. Statistical analyses were conducted using SPSS23.0. Rising research trends on flavonoids and saponins were observed since the 1990s and the 2000s, respectively. Studies on pharmacological targets and activities of flavonoids and saponins represent an important area of research advances over the past decade, and these important resources have been documented in open-access specialised databases and can be retrieved with ease. The rising research on flavonoids and saponins can be attributed, at least in part, to their links with some highly investigated fields of research, e.g., oxidative stress, inflammation and cancer; i.e., 6.88% and 3.03% of publications on oxidative stress cited by PubMed in 1990 - 2021 involved flavonoids and saponins, respectively, significantly higher than the percentage involving alkaloids (1.88%). The effects of flavonoids concern chronic venous insufficiency, cervical lesions, diabetes, rhinitis, dermatopathy, prostatitis, menopausal symptoms, angina pectoris, male pattern hair loss, lymphocytic leukaemia, gastrointestinal diseases and traumatic cerebral infarction, etc, while those of saponins may have impact on venous oedema in chronic deep vein incompetence, erectile dysfunction, acute impact injuries and systemic lupus erythematosus, etc. The volume of in vitro research appears way higher than in vivo and clinical studies, with only 10 meta-analyses and systematic reviews (involving 290 interventional and observational studies), and 36 clinical studies on flavonoids and saponins. Data are sorely needed on pharmacokinetics, in vitro pan-assay interferences, purity of tested compounds, interactions in complex herbal extracts, real impact of anti-oxidative strategies, and mid- and long-term toxicities. To fill these important gaps, further investigations are warranted. On the other hand, drug interactions may cause adverse effects but might also be useful for synergism, with the goals of enhancing effects or of detoxifying. Furthermore, the interactions between phytochemicals and the intestinal microbiota are worth investigating as the field may present a promising potential for novel drug development. [ABSTRACT FROM AUTHOR]
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- 2023
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5. Zhiheshouwu ethanol extract induces intrinsic apoptosis and reduces unsaturated fatty acids via SREBP1 pathway in hepatocellular carcinoma cells.
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Li, Hongliang, Xiang, Longchao, Yang, Nian, Cao, Fengjun, Li, Chen, Chen, Ping, Ruan, Xuzhi, Feng, Yibin, Zhou, Nian, and Wang, Xuanbin
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LIVER cancer , *CANCER cells , *CELLULAR pathology , *LIPIDS , *BIOMOLECULES - Abstract
Hepatocellular carcinoma (HCC) is the major incidence and one of the most life-threatening cancer. How to conquer HCC is a worldwide issue for patients. Zhiheshouwu ( Polygoni multiflori Radix Praeparata) is a Chinese medicinal herb exhibiting both lowering lipid and inhibiting cancer cells. However, it remains a matter if its inhibiting cancer cells is related to its lowering lipid. In this study, we investigate the effects of Zhiheshouwu ethanolic extract (HSWE) on apoptosis and the underlying mechanisms in Bel-7402 cells. The results showed that HSWE inhibited the proliferation with an increased level of ALT and AST in Bel-7402 cells. The decreased mitochondrial membrane potential (ΔΨm) was observed in HSWE-treated Bel-7402 cells. The flow cytometry results showed that HSWE triggered apoptosis. Since mitochondrial injury is characterized as intrinsic apoptotic cell death, these data indicated that HSWE may induce intrinsic apoptosis in Bel-7402 cells. In addition, HSWE decreased the production of unsaturated fatty acids, and inhibited the mRNA and protein of SCD1 and its up-stream factor, sterol-regulatory element binding proteins 1 (SREBP1), a master transcriptional regulator of lipogenic gene. Taken together, these data suggest that HSWE induces an intrinsic apoptosis, and reduced unsaturated fatty acids by blocking SREBP1 in hepatocellular carcinoma cells. [ABSTRACT FROM AUTHOR]
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- 2018
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6. TRPM8 activation improves energy expenditure in skeletal muscle and exercise endurance in mice.
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Li, Chen, Li, Jia, Xiong, Xiujuan, Liu, Ying, Lv, Yanxia, Qin, Shanshan, Liu, Dandan, Wei, Ronghua, Ruan, Xuzhi, Zhang, Jingxuan, Xu, Liang, Wang, Xuanbin, Chen, Jicheng, Zhang, Yonghong, and Zheng, Lanlan
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SKELETAL muscle physiology , *ENERGY metabolism regulation , *EXERCISE physiology , *FAT cells , *HEART disease risk factors - Abstract
Skeletal muscle serving as the major organ is responsible for energy expenditure and exercise endurance, which directly influence cardiometabolic risk factors. Transient receptor potential melastatin 8 (TRPM8), a Ca 2 + -permeable non-selective cation channel, plays vital roles in the regulation of various cellular functions. It has been reported that TRPM8 activation enhanced the energy metabolism of adipocytes. However, the involvement of TRPM8 in the energy metabolism of skeletal muscle remains unexplored. Our data revealed that TRPM8 was expressed in cultured C2C12 myocytes. Menthol treatment increased uncoupling protein 1 (UCP1) and peroxisome proliferator-activated receptor-γ coactivator 1α (PGC1α) expression in C2C12 myotubes through TRPM8 activation. Moreover, dietary menthol upregulated the expression of UCP1 and PGC1α in skeletal muscle of mice. In addition, dietary menthol enhanced exercise endurance and reduced blood lactic acid and triglycerides through TRPM8 activation. It is concluded that dietary menthol improves energy metabolism and exercise endurance by increasing UCP1 and PGC1α in skeletal muscles, suggesting dietary menthol might be a novel therapeutic approach for cardiometabolic diseases management and prevention. [ABSTRACT FROM AUTHOR]
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- 2018
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7. Characterization and functional analysis of four HYH splicing variants in Arabidopsis hypocotyl elongation.
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Li, Chen, Zheng, Lanlan, Zhang, Jingxuan, Lv, Yanxia, Liu, Jianping, Wang, Xuanbin, Palfalvi, Gergo, Wang, Guodong, and Zhang, Yonghong
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ARABIDOPSIS thaliana , *HYPOCOTYLS , *CELLULAR signal transduction , *GREEN algae , *PLANT species - Abstract
Arabidopsis thaliana LONG HYPOCOTYL5 (HY5) is a positive regulator of the light signaling pathway. The hy5 mutant has an elongated hypocotyl in all light conditions, whereas the hy5 homolog ( hyh ) mutant has a very weak phenotype, but only in blue light. However, overexpression of HYH rescues the elongated hypocotyl phenotype in the hy5 null mutant. Here, we report the identification of four HYH splicing variants in Arabidopsis . Alternative splicing in the 5′ region of the HYH gene occurred such that the proteins encoded by all four HYH variants retained their bZIP domain. In hypocotyl tissue, transcript levels of HYH.2 , HYH.3 , and HYH.4 were higher than those of HYH.1 . Like HY5 , all HYH variants were induced by light. Functional analysis of the four HYH variants, based on their abilities to complement the hy5 mutant, indicated that they have similar roles in hypocotyl development, and may function redundantly with HY5 . Our results indicate that the bZIP domain in HYH is critical for the function of four variants in the compensation of hy5 mutant in hypocotyl development. Additionally, while HY5/HYH is found in plant species ranging from green algae to flowering plants, the potential alternative splicing events are distinct in different species, with certain HYH variants found with greater frequency in some species than others. [ABSTRACT FROM AUTHOR]
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- 2017
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8. Corrigendum to "TRPM8 activation improves energy expenditure in skeletal muscle and exercise endurance in mice" [Gene 641 (2018) 111–116].
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Li, Chen, Li, Jia, Xiong, Xiujuan, Liu, Ying, Lv, Yanxia, Qin, Shanshan, Liu, Dandan, Wei, Ronghua, Ruan, Xuzhi, Zhang, Jingxuan, Xu, Liang, Wang, Xuanbin, Chen, Jicheng, Zhang, Yonghong, and Zheng, Lanlan
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SKELETAL muscle , *ACTIVATION energy , *MUSCLE growth , *GENES , *MICE , *EXERCISE - Published
- 2020
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