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Medical ultrasound images are corrupted by speckle noise, which is multiplicative. This noise limits the contrast resolution in these images and complicates image-based quantitative measurement and diagnosis. In this study, the speckle noise in the ultrasound image is modeled by local statistics of the intensity distribution. And the non-local mean (NLM) filter is utilized to filter additional noise by applying the redundancy information in noisy images. A hybrid denoising method is proposed in consideration of the characteristics of both the local statistics of speckle noise and the NLM filter. The study combines local statistics with the NLM filter to reduce speckle in ultrasound images. The local statistics of speckle noise is estimated by local patches, while the intensity of the denoising pixel is computed by the weighted average of all the pixels by using the NLM. The weight is determined according to the similarity measures between the intensities of the local patches. The performance of the proposed method is evaluated on synthetic data, simulated images, and real images. Results of quantitative analysis and visual inspection of the synthetic data and of the real images demonstrate that the proposed method outperforms the original NLM, as well as many previously developed methods. [ABSTRACT FROM AUTHOR]