Numerous studies have explored paleoenvironmental conditions in China's dune fields around the mid-Holocene (MH), ∼6000 calendar years ago, often based on individual paleosol-aeolian sand depositional sequences and local-scale landscape dynamics. So far, continent-scale modeling studies have only indirectly assessed dune activation and stabilization processes via changes in simulated precipitation, net precipitation (precipitation minus evaporation), and effective moisture (precipitation divided by evaporation). Here we conducted a comprehensive study using gridded data on potential evapotranspiration, precipitation, and surface wind velocity from 13 climate models participating in the Paleoclimate Modeling Intercomparison Project phases 4 (PMIP4) and compared the model results with geological records. Our evaluation of spatial patterns of dune activity in northern China around the MH reveals that the intensity of annual MH dune activity exhibited significant differences between the eastern and western parts of Chinese deserts compared to those of the preindustrial period (PI). Dune activity was significantly weaker in the eastern region, while in the western part, it was considerably stronger. The key drivers of this disparity were the distinct spatial variations in near-surface wind speed and effective moisture between the two regions. Compared with the optically stimulated luminescence ages of the paleosol-aeolian sand sedimentary sequences derived from a compilation of geological records from 88 sites across northern China, the model results suggest that the weakening of dune activity and the process of dune stabilization in eastern China around the MH were mainly attributed to a significant increase in effective moisture and a concurrent decrease in near-surface wind speed due to the intensified East Asian summer monsoon. Additionally, the weakening of westerlies in western China resulted in reduced effective moisture, contributing to increased sand availability for dune development and subsequent desert expansion. • Mid-Holocene dune activity in Chinese deserts varied regionally, differing from preindustrial period. • Varied wind speed and moisture caused different mid-Holocene aeolian activities in northern China's western and eastern desert belt. • Numerical simulations aid in interpreting field-based geological findings comprehensively. [ABSTRACT FROM AUTHOR]