1. Circulating GLP-1 Levels in Patients with Pheochromocytoma/Paraganglioma.
- Author
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Chen, Nan, Chen, Yan, Lai, Fenghua, Chen, Li, Zeng, Rui, Pei, Ling, Wu, Liting, Wang, Chenxue, Li, Yanbing, Xiao, Haipeng, and Cao, Xiaopei
- Subjects
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CONFIDENCE intervals , *GLUCAGON-like peptide 1 , *CATECHOLAMINES , *MULTIPLE regression analysis , *REGRESSION analysis , *PHEOCHROMOCYTOMA , *DESCRIPTIVE statistics , *PARAGANGLIOMA , *DATA analysis software - Abstract
The sympathoadrenal system has been shown to stimulate the secretory activity of enteroendocrine cells, although the response is transient. Our aim was to investigate the effects of long-term catecholamine excess on circulating glucagon-likepeptide-1 (GLP-1) levels in patients with pheochromocytoma/paraganglioma (PPGL). Thirty patients diagnosed with PPGL were analyzed. A significant negative association was observed between fasting plasma GLP-1 levels and elevated plasma-free metanephrine (r = − 0.407 , p = 0.026). After adjustment for age, sex, body mass index (BMI), serum creatinine, and the presence of hyperglycemia, the negative association between plasma GLP-1 and metanephrine persisted by multiple linear regression analysis (β = − 0.493 , p = 0.013). Positive correlations between fasting glucose and plasma metanephrine (r = 0.380 , p = 0.038) and normetanephrine levels (r = 0.450 , p = 0.013) were also found. Mean fasting levels of total GLP-1 increased significantly from 25.81 to 39.01 pmol/L (p = 0.017) after PPGL resection. In conclusion, long-term overproduction of catecholamines appears to induce suppression of GLP-1 production compared to an acute response to a stress stimulus. Further studies are required to elucidate the mechanism of GLP-1 secretion with chronic exposure to catecholamine. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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