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This paper illustrates a large research university library's experience in reusing data for research collected both within and outside of the library. The purpose of the paper is 1) to demonstrate when, why and how data are reused in a large public research university library, 2) to share tips on what to consider when reusing and reproducing data for research data, including issues of replicability and research ethics, and 3) to share challenges and lessons learned from data reuse and reproducibility experiences. This paper presents five proposed opportunities for data reuse conducted by three researchers at the institution's library, which resulted in three successful instances of data reuse and two failed data reuses. Learning from successful and failed experiences is critical to understand what works and what does not work in order to identify best practices for data reuse. This paper will be helpful for librarians who intend to reuse data for research and publication. [ABSTRACT FROM AUTHOR]