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Rodent electroencephalography (EEG) in preclinical research is frequently conducted in behaving animals. However, the difficulty inherent in identifying EEG epochs associated with a particular behavior or cue is a significant obstacle to more efficient analysis. In this paper we highlight a new solution, using infrared event stamping to accurately synchronize EEG, recorded from superficial sites above the hippocampus and prefrontal cortex, with video motion tracking data in a transgenic Alzheimer's disease (AD) mouse model. Epochs capturing specific behaviors were automatically identified and extracted prior to further analysis. This was achieved by the novel design of an ultra-miniature wearable EEG recorder, the NAT-1 device, and its in-situ IR recording module. The device is described in detail, and its contribution to enabling new neuroscience is demonstrated. [ABSTRACT FROM AUTHOR]

Neuroscientists seek efficient solutions for deciphering the sophisticated unknowns of the brain. Effective development of complicated brain-related tools is the focal point of research in neuroscience and neurotechnology. Thanks to today’s technological advancements, the physical development of high-density and high-resolution neural interfaces has been made possible. This is where the critical bottleneck in receiving the expected functionality from such devices shifts to transferring, processing, and subsequently analyzing the massive neurophysiological extra-cellular data recorded. To respond to this inevitable concern, a spectrum of neuronal signal processing techniques have been proposed to extract task-related informative content of the signals conveying neuronal activities, and eliminate the irrelevant contents. Such techniques provide powerful tools for a wide range of neuroscience research, from low-level perception to high-level cognition. Data transformations are among the most efficient processing techniques that serve this purpose by properly changing the data representation. Mapping the data from its original domain (i.e., the time-space domain) to a new representational domain, data transformations change the viewing angle of observing the informative content of the data. This paper reviews the employment of data transformations in order to process neuronal signals and their three key applications, including spike detection, spike sorting, and data compression. [ABSTRACT FROM AUTHOR]

Neuroimaging experiments in general, and EEG experiments in particular, must take care to avoid confounds. A recent TPAMI paper uses data that suffers from a serious previously reported confound. We demonstrate that their new model and analysis methods do not remedy this confound, and therefore that their claims of high accuracy and neuroscience relevance are invalid. [ABSTRACT FROM AUTHOR]

We believe that this special issue will serve to increase the public awareness and foster discussions on the multiple worldwide BRAIN initiatives, both within and outside the IEEE, providing an impetus for development of long-term cost-effective healthcare solutions. We also believe that the topics presented in this special issue will serve as scientific evidence for health and policy advocates of the value of neurotechnologies for improving the neurological and mental health and wellbeing of the general population. Below we briefly highlight the papers and technologies in this special issue. [ABSTRACT FROM AUTHOR]

In this paper, our objective is to propose a stability concept within the graph model for conflict resolution (GMCR) that does not require knowledge about preferences of other decision makers (DMs) in the conflict and is flexible to analyze the conflict with variable horizon. For that we propose the use of the maximin decision rule within the GMCR. More specifically, we consider a GMCR with two DMs and introduce the concept of Maximinh stability with horizon h for a given DM. The Maximinh stability concept was inspired by the notion of limited-move stability with horizon h present in the GMCR literature and it is adequate for modeling cautious DMs in conflicts where they have no knowledge about the other DM’s preferences. We establish what is the relationship among the Maximinhstabilities for different horizons and the relationship among Maximinh stability and other GMCR stability concepts. Finally, we present an application to illustrate the proposed stability concept, namely, a neuroscience technological selection conflict in China. [ABSTRACT FROM AUTHOR]

Deep brain stimulation (DBS) is a neurosurgical treatment in, e.g., Parkinson’s Disease. Electrical stimulation in DBS is delivered to a certain target through electrodes implanted into the brain. Recent developments aiming at better stimulation target coverage and lesser side effects have led to an increase in the number of contacts in a DBS lead as well as higher hardware complexity. This paper proposes an optimization-based approach to alleviation of the fault impact on the resulting therapeutical effect in field steering DBS. Faulty contacts could be an issue given recent trends of increasing number of contacts in DBS leads. Hence, a fault detection/alleviation scheme, such as the one proposed in this paper, is necessary ensure resilience in the chronic stimulation. Two alternatives are considered and compared with the stimulation prior to the fault: one using higher amplitudes on the remaining contacts and another with alleviating contacts in the neighborhood of the faulty one. Satisfactory compensation for a faulty contact can be achieved in both ways. However, to designate alleviating contacts, a model-based optimization procedure is necessary. Results suggest that stimulating with more contacts yields configurations that are more robust to contact faults, though with reduced selectivity. [ABSTRACT FROM PUBLISHER]

The papers in this special section focus on neuro-informatics which is considered one of the most attractive research fields for scientists, engineers, practitioners and physicians due to its profound importance in healthcare and in our lives. Human curiosity, the BRAIN project in USA with a very large funding budget, and the exponential evolution of computational informatics and nanotech during the last two decades have inspired and motivated many researchers around the globe to contribute with their research to the brain. The papers are associated with the IEEE BIBE-2017 Conference. [ABSTRACT FROM AUTHOR]

In this paper, we propose a new inference procedure for understanding non-stationary processes, under the framework of evolutionary spectra developed by Priestley. Among various frameworks of modeling non-stationary processes, the distinguishing feature of the evolutionary spectra is its focus on the physical meaning of frequency. The classical estimate of the evolutionary spectral density is based on a double-window technique consisting of a short-time Fourier transform and a smoothing. However, smoothing is known to suffer from the so-called bias leakage problem. By incorporating Thomson's multitaper method that was originally designed for stationary processes, we propose an improved estimate of the evolutionary spectral density, and analyze its bias/variance/resolution tradeoff. As an application of the new estimate, we further propose a non-parametric rank-based stationarity test, and provide various experimental studies. [ABSTRACT FROM AUTHOR]

Contribution: This paper demonstrates curricular modules that incorporate engineering model-based approaches, including concepts related to circuits, systems, modeling, electrophysiology, programming, and software tutorials that enhance learning in undergraduate neuroscience courses. These modules can also be integrated into other neuroscience courses. Background: Educators in biological and physical sciences urge incorporation of computation and engineering approaches into biology. Model-based approaches can provide insights into neural function; prior studies show these are increasingly being used in research in biology. Reports about their integration in undergraduate neuroscience curricula, however, are scarce. There is also a lack of suitable courses to satisfy engineering students’ interest in the challenges in the growing area of neural sciences. Intended Outcomes: (1) Improved student learning in interdisciplinary neuroscience; (2) enhanced teaching by neuroscience faculty; (3) research preparation of undergraduates; and 4) increased interdisciplinary interactions. Application Design: An interdisciplinary undergraduate neuroscience course that incorporates computation and model-based approaches and has both software- and wet-lab components, was designed and co-taught by colleges of engineering and arts and science. Findings: Model-based content improved learning in neuroscience for three distinct groups: 1) undergraduates; 2) Ph.D. students; and 3) post-doctoral researchers and faculty. Moreover, the importance of the content and the utility of the software in enhancing student learning was rated highly by all these groups, suggesting a critical role for engineering in shaping the neuroscience curriculum. The model for cross-training also helped facilitate interdisciplinary research collaborations. [ABSTRACT FROM AUTHOR]

Fast-scan cyclic voltammetry (FSCV) is an electrochemical sensing method used for measuring the concentration of neurotransmitters within the brain. FSCV is typically conducted using benchtop equipment, providing accurate and high temporal resolution measurements. However, the large size and high cost of benchtop FSCV systems pose significant limitations in widespread preclinical use of FSCV. Recent technological improvements have facilitated the miniaturization of FSCV equipment, creating systems that can be mounted on the subject as they are small and lightweight. One key remaining bottleneck in the emerging miniaturized FSCV systems is that their data typically needs to be transmitted to an external computer for analysis. This paper presents a review on the current miniature FSCV devices. It discusses the latest improvements in voltage scan waveforms that help increase the sensitivity of measuring specific analytes, for use in miniaturized FSCV. It also tabulates analytes that have been detected using FSCV. It also details current issues with FSCV and the latest achievements in post-processing of FSCV data to better identify target analytes. Furthermore, the emerging miniature FSCV devices that have integrated on-board data processing capabilities to mitigate external data processing are discussed. These advances can accelerate neurochemistry research, reducing time spent analysing data on external computers, and allowing for investigation into questions on neurotransmitter dynamics in target brain regions. [ABSTRACT FROM AUTHOR]

Due to their complex nature, emotions cannot be properly understood from the perspective of a single discipline. In this paper, I discuss how the use of robots as models is beneficial for interdisciplinary emotion research. Addressing this issue through the lens of my own research, I focus on a critical analysis of embodied robots models of different aspects of emotion, relate them to theories in psychology and neuroscience, and provide representative examples. I discuss concrete ways in which embodied robot models can be used to carry out interdisciplinary emotion research, assessing their contributions: as hypothetical models, and as operational models of specific emotional phenomena, of general emotion principles, and of specific emotion “dimensions”. I conclude by discussing the advantages of using embodied robot models over other models. [ABSTRACT FROM AUTHOR]

In this paper, we propose a novel neural network model, called bi-hemisphere domain adversarial neural network (BiDANN) model, for electroencephalograph (EEG) emotion recognition. The BiDANN model is inspired by the neuroscience findings that the left and right hemispheres of human's brain are asymmetric to the emotional response. It contains a global and two local domain discriminators that work adversarially with a classifier to learn discriminative emotional features for each hemisphere. At the same time, it tries to reduce the possible domain differences in each hemisphere between the source and target domains so as to improve the generality of the recognition model. In addition, we also propose an improved version of BiDANN, denoted by BiDANN-S, for subject-independent EEG emotion recognition problem by lowering the influences of the personal information of subjects to the EEG emotion recognition. Extensive experiments on the SEED database are conducted to evaluate the performance of both BiDANN and BiDANN-S. The experimental results have shown that the proposed BiDANN and BiDANN models achieve state-of-the-art performance in the EEG emotion recognition. [ABSTRACT FROM AUTHOR]

In many domains, there is significant interest in capturing novel relationships between time series that represent activities recorded at different nodes of a highly complex system. In this paper, we introduce multipoles, a novel class of linear relationships between more than two time series. A multipole is a set of time series that have strong linear dependence among themselves, with the requirement that each time series makes a significant contribution to the linear dependence. We demonstrate that most interesting multipoles can be identified as cliques of negative correlations in a correlation network. Such cliques are typically rare in a real-world correlation network, which allows us to find almost all multipoles efficiently using a clique-enumeration approach. Using our proposed framework, we demonstrate the utility of multipoles in discovering new physical phenomena in two scientific domains: climate science and neuroscience. In particular, we discovered several multipole relationships that are reproducible in multiple other independent datasets and lead to novel domain insights. [ABSTRACT FROM AUTHOR]

This paper presents a bidirectional brain machine interface (BMI) microsystem designed for closed-loop neuroscience research, especially experiments in freely behaving animals. The system-on-chip (SoC) consists of 16-channel neural recording front-ends, neural feature extraction units, 16-channel programmable neural stimulator back-ends, in-channel programmable closed-loop controllers, global analog-digital converters (ADC), and peripheral circuits. The proposed neural feature extraction units includes 1) an ultra low-power neural energy extraction unit enabling a 64-step natural logarithmic domain frequency tuning, and 2) a current-mode action potential (AP) detection unit with time-amplitude window discriminator. A programmable proportional-integral-derivative (PID) controller has been integrated in each channel enabling a various of closed-loop operations. The implemented ADCs include a 10-bit voltage-mode successive approximation register (SAR) ADC for the digitization of the neural feature outputs and/or local field potential (LFP) outputs, and an 8-bit current-mode SAR ADC for the digitization of the action potential outputs. The multi-mode stimulator can be programmed to perform monopolar or bipolar, symmetrical or asymmetrical charge balanced stimulation with a maximum current of 4 mA in an arbitrary channel configuration. The chip has been fabricated in 0.18$\mu$ m CMOS technology, occupying a silicon area of 3.7 mm$^2$. The chip dissipates 56 $\mu$W/ch on average. General purpose low-power microcontroller with Bluetooth module are integrated in the system to provide wireless link and SoC configuration. Methods, circuit techniques and system topology proposed in this work can be used in a wide range of relevant neurophysiology research, especially closed-loop BMI experiments. [ABSTRACT FROM PUBLISHER]

Recent demand and initiatives in brain research have driven significant interest toward developing chronically implantable neural interface systems with high spatiotemporal resolution and spatial coverage extending to the whole brain. Electroencephalography-based systems are noninvasive and cost efficient in monitoring neural activity across the brain, but suffer from fundamental limitations in spatiotemporal resolution. On the other hand, neural spike and local field potential (LFP) monitoring with penetrating electrodes offer higher resolution, but are highly invasive and inadequate for long-term use in humans due to unreliability in long-term data recording and risk for infection and inflammation. Alternatively, electrocorticography (ECoG) promises a minimally invasive, chronically implantable neural interface with resolution and spatial coverage capabilities that, with future technology scaling, may meet the needs of recently proposed brain initiatives. In this paper, we discuss the challenges and state-of-the-art technologies that are enabling next-generation fully implantable high-density ECoG interfaces, including details on electrodes, data acquisition front-ends, stimulation drivers, and circuits and antennas for wireless communications and power delivery. Along with state-of-the-art implantable ECoG interface systems, we introduce a modular ECoG system concept based on a fully encapsulated neural interfacing acquisition chip (ENIAC). Multiple ENIACs can be placed across the cortical surface, enabling dense coverage over wide area with high spatiotemporal resolution. The circuit and system level details of ENIAC are presented, along with measurement results. [ABSTRACT FROM AUTHOR]

This paper provides a focused and organized review of the research progress on neurophysiological indicators, also called “neurometrics,” to show how they can effectively address some of the most important human factors (HFs) needs in the air traffic management (ATM) field. In order to better understand and highlight available opportunities of such neuroscientific applications, state of the art on the most involved HFs and related cognitive processes (e.g., mental workload and cognitive training) are presented together with examples of possible applications in current and future ATM scenarios. Furthermore, this paper will discuss the potential enhancements that further research and development activities could bring to the efficiency and safety of the ATM service. [ABSTRACT FROM PUBLISHER]

Quantifying causal (effective) interactions between different brain regions are very important in neuroscience research. Many conventional methods estimate effective connectivity based on linear models. However, using linear connectivity models may oversimplify the functions and dynamics of the brain. In this paper, we propose a causal relationship estimator called nonlinear Causal Relationship Estimation by Artificial Neural Network (nCREANN) that identifies both linear and nonlinear components of effective connectivity in the brain. Furthermore, it can distinguish between these two types of connectivity components by calculating the linear and nonlinear parts of the network input-output mapping. The nCREANN performance has been verified using synthesized data and then it has been applied on EEG data collected during rest in children with autism spectrum disorder (ASD) and typically developing (TD) children. The results show that overall linear connectivity in TD subjects is higher, while the nonlinear connectivity component is more dominant in ASDs. We suggest that our findings may represent different underlying neural activation dynamics in ASD and TD subjects. The results of nCREANN may provide new insight into the connectivity between the interactive brain regions. [ABSTRACT FROM AUTHOR]

Previous studies have attempted to investigate the peripheral neural mechanisms implicated in tactile perception, but the neurophysiological data in humans involved in tactile spatial location perception to help the brain orient the body and interact with its surroundings are not well understood. In this paper, we use single-trial electroencephalogram (EEG) measurements to explore the perception of tactile stimuli located on participants’ right forearm, which were approximately equally spaced centered on the body midline, 2 leftward and 2 rightward of midline. An EEG-based signal analysis approach to predict the location of the tactile stimuli is proposed. Offline classification suggests that tactile location can be detected from EEG signals in single trial (four-class classifier for location discriminate can achieve up to 96.76%) with a short response time (600 milliseconds after stimulus presentation). From a human-machine-interaction (HMI) point of view, this could be used to design a real-time reactive control machine for patients, e.g., suffering from hypoesthesia. [ABSTRACT FROM PUBLISHER]

Quantitative phase imaging (QPI) is an emerging label-free modality that attracts significant interest in biomedicine in general and neuroscience in particular. Based on the principle of interferometry, QPI precisely maps the optical pathlength induced by the sample, and, thus, can visualize extremely transparent samples. The QPI field has grown rapidly in the past decade, and reliable instruments have been developed for in-depth biological studies. One particular figure of merit associated with QPI techniques describes the temporal phase sensitivity of instruments. Recently, several common path interferometry methods have been developed, which yield high stability and nanometer scale pathlength sensitivity. In neuroscience, QPI has shown unique capabilities in quantifying neural growth and dynamics in cell cultures, as well as high contrast imaging of brain tissue slices. In this paper, we review the principles of QPI, novel QPI technology, advances in data processing, and a number of exciting applications in neuroscience. [ABSTRACT FROM AUTHOR]

The human brain can be represented as a graph in which neural units such as cells or small volumes of tissue are heterogeneously connected to one another through structural or functional links. Brain graphs are parsimonious representations of neural systems that have begun to offer fundamental insights into healthy human cognition, as well as its alteration in disease. A critical open question in network neuroscience lies in how neural units cluster into densely interconnected groups that can provide the coordinated activity that is characteristic of perception, action, and adaptive behaviors. Tools that have proven particularly useful for addressing this question are community detection approaches, which can identify communities or modules: groups of neural units that are densely interconnected with other units in their own group but sparsely interconnected with units in other groups. In this paper, we describe a common community detection algorithm known as modularity maximization, and we detail its application to brain graphs constructed from neuroimaging data. We pay particular attention to important algorithmic considerations, especially in recent extensions of these techniques to graphs that evolve in time. After recounting a few fundamental insights that these techniques have provided into brain function, we highlight potential avenues of methodological advancements for future studies seeking to better characterize the patterns of coordinated activity in the brain that accompany human behavior. This tutorial provides a reader with an introduction to theoretical considerations pertinent to the generation of brain graphs, an understanding of modularity maximization for community detection, a resource of statistical measures that can be used to characterize community structure, and an appreciation of the usefulness of these approaches in uncovering behaviorally relevant network dynamics in neuroimaging data. [ABSTRACT FROM AUTHOR]

Efficient classification of mental workload, an important issue in neuroscience, is limited, so far to single task, while cross-task classification remains a challenge. Furthermore, network approaches have emerged as a promising direction for studying the complex organization of the brain, enabling easier interpretation of various mental states. In this paper, using two mental tasks (N-back and mental arithmetic), we present a framework for cross- as well as within-task workload discrimination by utilizing multiband electroencephalography (EEG) cortical brain connectivity. In detail, we constructed functional networks in EEG source space in different frequency bands and considering the individual functional connections as classification features, we identified salient feature subsets based on a sequential feature selection algorithm. These connectivity subsets were able to provide accuracy of 87% for cross-task, 88% for N-back task, and 86% for mental arithmetic task. In conclusion, our method achieved to detect a small number of discriminative interactions among brain areas, leading to high accuracy in both within-task and cross-task classifications. In addition, the identified functional connectivity features, the majority of which were detected in frontal areas in theta and beta frequency bands, helped delineate the shared as well as the distinct neural mechanisms of the two mental tasks. [ABSTRACT FROM PUBLISHER]

Objective: This paper aims to identify periods of depression using geolocation movements recorded from mobile phones in a prospective community study of individuals with bipolar disorder (BD). Methods: Anonymized geographic location recordings from 22 BD participants and 14 healthy controls (HC) were collected over 3 months. Participants reported their depressive symptomatology using a weekly questionnaire (QIDS-SR16). Recorded location data were preprocessed by detecting and removing imprecise data points and features were extracted to assess the level and regularity of geographic movements of the participant. A subset of features were selected using a wrapper feature selection method and presented to 1) a linear regression model and a quadratic generalized linear model with a logistic link function for questionnaire score estimation; and 2) a quadratic discriminant analysis classifier for depression detection in BD participants based on their questionnaire responses. R esults: HC participants did not report depressive symptoms and their features showed similar distributions to nondepressed BD participants. Questionnaire score estimation using geolocation-derived features from BD participants demonstrated an optimal mean absolute error rate of 3.73, while depression detection demonstrated an optimal (median \pm IQR) \text{F}_{1} score of 0.857 \pm$ 0.022 using five features (classification accuracy: 0.849 $\pm$ 0.016; sensitivity: 0.839 $\pm$ 0.014; specificity: 0.872 $\pm$ 0.047). Conclusion: These results demonstrate a strong link between geographic movements and depression in bipolar disorder. S ignificance: To our knowledge, this is the first community study of passively recorded objective markers of depression in bipolar disorder of this scale. The techniques could help individuals monitor their depression and enable healthcare providers to detect those in need of care or treatment. [ABSTRACT FROM AUTHOR]

Suppose that we have r sensors and each one intends to send a function {g}_{i} (e.g., a signal or an image) to a receiver common to all r sensors. During transmission, each gi gets convolved with a function {f}i . The receiver records the function y , given by the sum of all these convolved signals. When and under which conditions is it possible to recover the individual signals gi and the blurring functions fi from just one received signal y ? This challenging problem, which intertwines blind deconvolution with blind demixing, appears in a variety of applications, such as audio processing, image processing, neuroscience, spectroscopy, and astronomy. It is also expected to play a central role in connection with the future Internet-of-Things. We will prove that under reasonable and practical assumptions, it is possible to solve this, otherwise, highly ill-posed problem and recover the $r$ transmitted functions gi and the impulse responses fi in a robust, reliable, and efficient manner, from just one single received function y by solving a semidefinite program. We derive explicit bounds on the number of measurements needed for successful recovery and prove that our method is robust in the presence of noise. Our theory is actually suboptimal, since numerical experiments demonstrate that, quite remarkably, recovery is still possible if the number of measurements is close to the number of degrees of freedom. [ABSTRACT FROM PUBLISHER]

In vivo whole-body imaging of small animals plays an important role for biomedical studies. In particular, animals like the fruit fly Drosophila melanogaster or the nematode Caenorhabditis elegans are popular model organisms for preclinical research since they offer sophisticated genetic tool-kits. Recording these translucent animals with high contrast in a large arena is however not trivial. Furthermore, fluorescent proteins are widely used to mark cells in vivo and report their functions. This paper introduces a novel optical imaging technique called FIM^2c\; enabling simultaneous detection of the animals posture and movement as well as fluorescent markers like green fluorescent protein (GFP). FIM^2c\; utilizes frustrated total internal reflection of two distinct wavelengths and captures both, reflected and emitted light. The resultant two-color high-contrast images are superb compared to other imaging systems for larvae or worms. This multipurpose method enables a large variety of different experimental approaches. For example, FIM^2c\;can be used to image GFP positive cells/tissues/animals and supports the integration of fluorescent tracers into multitarget tracking paradigms. Moreover, optogenetic tools can be applied in large-scale behavioral analysis to manipulate and study neuronal functions. To demonstrate the benefit of our system, we use FIM^2c\; to resolve colliding larvae in a high-throughput approach, which was impossible given the existing tools. Finally, we present a comprehensive database including images and locomotion features of more than $1300$ resolved collisions available for the community. In conclusion, FIM^2c\;is a versatile tool for advanced imaging and locomotion analysis for a variety of different model organisms. [ABSTRACT FROM AUTHOR]

In the wake of recent advances in experimental methods in neuroscience, the ability to record in-vivo neuronal activity from awake animals has become feasible. The availability of such rich and detailed physiological measurements calls for the development of advanced data analysis tools, as commonly used techniques do not suffice to capture the spatio-temporal network complexity. In this paper, we propose a new hierarchical coupled-geometry analysis that implicitly takes into account the connectivity structures between neurons and the dynamic patterns at multiple time scales. Our approach gives rise to the joint organization of neurons and dynamic patterns in data-driven hierarchical data structures. These structures provide local to global data representations, from local partitioning of the data in flexible trees through a new multiscale metric to a global manifold embedding. The application of our techniques to in-vivo neuronal recordings demonstrate the capability of extracting neuronal activity patterns and identifying temporal trends, associated with particular behavioral events and manipulations introduced in the experiments. [ABSTRACT FROM PUBLISHER]

Transcranial magnetic stimulation (TMS) is a popular method for the non-invasive stimulation of neurons in the human brain. It has become a standard instrument in experimental brain research and approved for a range of diagnostic and therapeutic applications in neurology and psychiatry. For major depressive disorder, TMS offers effective treatment with lower side effects than other therapies. Depression treatment is currently either performed with focal figure-of-eight coils or with rather distributed H1-type coils. In conventional protocols, the latter appears to even show superior performance. Still, their use is rather limited due to the complexity of the H coil. The H coil furthermore includes various segments that complicate manufacturing and drive the cost. In this paper, we present an electromagnetic equivalent for the H1 coil, which we call surface-projected, H1sp, through vector projection and Huygens’ and Love’s equivalence principle. The latter in principle allows to generate the electromagnetic field distribution inside a closed equivalence volume, e.g., a sphere, exclusively with currents on any closed surface around the volume. We aim at an anatomy-independent equivalent, i.e., the coil should generate the same induced electric field conditions as the original coil for any anatomy inside this equivalence volume, which matching in even a high number of sample anatomies could not fulfill. As the highest current utilization and efficiencies are achieved when all coil winding elements are as close to the target—i.e., the brain—as possible, we derived an equivalent entirely residing on a spherical shell on top of the head. In contrast to other coil design or optimization approaches, the procedure does not require any ad-hoc steps or heuristics but is an explicit forward Hilbert-space vector projection or base change. The resulting equivalent coil generates by design the same field conditions for any head anatomy inside but omits many complexity-, loss-, and leakage-flux-generating features of the initial H1 coil, such as the vertical coil winding segments or hard-to-manufacture sharp turns. For the same induced electric field magnitude and spatial profile, the equivalent H coil requires < 65% of the magnetic field energy and < 55% of the wire length. The comparably simple winding pattern promises the use of notable thicker wire than the initial H1 coil design with several relatively sharp corners.

Neuromorphic computing is an emerging research field that aims to develop new intelligent systems by integrating theories and technologies from multiple disciplines, such as neuroscience, deep learning and microelectronics. Various software frameworks have been developed for related fields, but an efficient framework dedicated to spike-based computing models and algorithms is lacking. In this work, we present a Python-based spiking neural network (SNN) simulation and training framework, named SPAIC, that aims to support brain-inspired model and algorithm research integrated with features from both deep learning and neuroscience. To integrate different methodologies from multiple disciplines and balance flexibility and efficiency, SPAIC is designed with a neuroscience-style frontend and a deep learning-based backend. Various types of examples are provided to demonstrate the wide usability of the framework, including neural circuit simulation, deep SNN learning and neuromorphic applications. As a user-friendly, flexible, and high-performance software tool, it will help accelerate the rapid growth and wide applicability of neuromorphic computing methodologies. [ABSTRACT FROM AUTHOR]

We develop a theoretical framework for defining and identifying flows of information in computational systems. Here, a computational system is assumed to be a directed graph, with “clocked” nodes that send transmissions to each other along the edges of the graph at discrete points in time. We are interested in a definition that captures the dynamic flow of information about a specific message, and which guarantees an unbroken “information path” between appropriately defined inputs and outputs in the directed graph. Prior measures, including those based on Granger Causality and Directed Information, fail to provide clear assumptions and guarantees about when they correctly reflect information flow about a message. We take a systematic approach—iterating through candidate definitions and counterexamples—to arrive at a definition for information flow that is based on conditional mutual information, and which satisfies desirable properties, including the existence of information paths. Finally, we describe how information flow might be detected in a noiseless setting, and provide an algorithm to identify information paths on the time-unrolled graph of a computational system. [ABSTRACT FROM AUTHOR]

EEG signals have been reported to be informative and reliable for emotion recognition in recent years. However, the inter-subject variability of emotion-related EEG signals still poses a great challenge for the practical applications of EEG-based emotion recognition. Inspired by recent neuroscience studies on inter-subject correlation, we proposed a Contrastive Learning method for Inter-Subject Alignment (CLISA) to tackle the cross-subject emotion recognition problem. Contrastive learning was employed to minimize the inter-subject differences by maximizing the similarity in EEG signkal representations across subjects when they received the same emotional stimuli in contrast to different ones. Specifically, a convolutional neural network was applied to learn inter-subject aligned spatiotemporal representations from EEG time series in contrastive learning. The aligned representations were subsequently used to extract differential entropy features for emotion classification. CLISA achieved state-of-the-art cross-subject emotion recognition performance on our THU-EP dataset with 80 subjects and the publicly available SEED dataset with 15 subjects. It could generalize to unseen subjects or unseen emotional stimuli in testing. Furthermore, the spatiotemporal representations learned by CLISA could provide insights into the neural mechanisms of human emotion processing. [ABSTRACT FROM AUTHOR]

We consider three different ways of algorithmization of the Janashia–Lagvilava spectral factorization method. The first algorithm is faster than the second one, however, it is only suitable for matrices of low dimension. The second algorithm, on the other hand, can be applied to matrices of substantially larger dimension. The third algorithm is a superfast implementation of the method, but only works in the polynomial case under the additional restriction that the zeros of the determinant are not too close to the boundary. All three algorithms fully utilize the advantage of the method, which carries out spectral factorization of leading principal submatrices step-by-step. The corresponding results of numerical simulations are reported in order to describe the characteristic features of each algorithm and compare them to other existing algorithms. [ABSTRACT FROM AUTHOR]

This paper presents Abstractocyte, a system for the visual analysis of astrocytes and their relation to neurons, in nanoscale volumes of brain tissue. Astrocytes are glial cells, i.e., non-neuronal cells that support neurons and the nervous system. The study of astrocytes has immense potential for understanding brain function. However, their complex and widely-branching structure requires high-resolution electron microscopy imaging and makes visualization and analysis challenging. Furthermore, the structure and function of astrocytes is very different from neurons, and therefore requires the development of new visualization and analysis tools. With Abstractocyte, biologists can explore the morphology of astrocytes using various visual abstraction levels, while simultaneously analyzing neighboring neurons and their connectivity. We define a novel, conceptual 2D abstraction space for jointly visualizing astrocytes and neurons. Neuroscientists can choose a specific joint visualization as a point in this space. Interactively moving this point allows them to smoothly transition between different abstraction levels in an intuitive manner. In contrast to simply switching between different visualizations, this preserves the visual context and correlations throughout the transition. Users can smoothly navigate from concrete, highly-detailed 3D views to simplified and abstracted 2D views. In addition to investigating astrocytes, neurons, and their relationships, we enable the interactive analysis of the distribution of glycogen, which is of high importance to neuroscientists. We describe the design of Abstractocyte, and present three case studies in which neuroscientists have successfully used our system to assess astrocytic coverage of synapses, glycogen distribution in relation to synapses, and astrocytic-mitochondria coverage. [ABSTRACT FROM PUBLISHER]

Optogenetics allows control of neuronal activity with unprecedented spatiotemporal precision, and has enabled both significant advances in neuroscience and promising clinical prospects for some neurological, cardiac, and sensory disorders. The ability to chronically stimulate light-sensitive excitable cells is crucial for developing useful research tools and viable long-term treatment strategies. Popular optogenetic stimulation devices often rely on bench-top light-sources tethered via an optical fibre to the research animal, or significant componentry protruding externally from animal. These approaches are prone to infection, vulnerable to damage and restrict the experimental approaches that can be conducted. An ideal optogenetic stimulator would be contained entirely within the animal and provide precisely controlled optical output. However, existing prototypes of fully implantable devices rely on amplitude tuning of wireless power, which can vary strongly with environmental conditions. Here we show that pulse-width modulation (PWM) of the intensity of a light-emitting diode (LED) can enable control of photo-stimulation intensity equivalent to direct amplitude modulation. This result has significant implications for fully implantable light delivery tools, as PWM can be implemented with simple and miniaturized circuit architectures. We have modified a telemeter device previously developed by our group to include a small form-factor LED capable of generating sufficient optical power with manageable electrical power requirements and minimal heat generation. We have tested key device components in an in vitro mouse brain slice preparation and shown that pulse-width-modulation is an alternative method to modulate photo-stimulation intensity using a miniature circuit and providing easy control. [ABSTRACT FROM PUBLISHER]

This review focuses on recent directions stemming from work by the authors and collaborators in the emerging field of neurotechnology. Neurotechnology has the potential to provide a greater understanding of the structure and function of the complex neural circuits in the brain, as well as impacting the field of brain–machine interfaces (BMI). We envision ultralow-power wireless neural interface systems that are life-lasting, fully integrated, and that supports bidirectional data flow with high bandwidth. Moreover, we believe in the importance of building neural interface technology that is truly tetherless, has a very small recording footprint, and little to no mechanical coupling between the sensor and the external world. We believe these developments will impact both neuroscience and neurology, revealing fundamental insight about how the nervous system functions in health and disease. [ABSTRACT FROM AUTHOR]

Human brain is a complex yet economically organized system, where a small portion of critical hub regions support the majority of brain functions. The identification of common hub nodes in a population of networks is often simplified as a voting procedure on the set of identified hub nodes across individual brain networks, which ignores the intrinsic data geometry and partially lacks the reproducible findings in neuroscience. Hence, we propose a first-ever group-wise hub identification method to identify hub nodes that are common across a population of individual brain networks. Specifically, the backbone of our method is to learn common graph embedding that can represent the majority of local topological profiles. By requiring orthogonality among the graph embedding vectors, each graph embedding as a data element is residing on the Grassmannian manifold. We present a novel Grassmannian manifold optimization scheme that allows us to find the common graph embeddings, which not only identify the most reliable hub nodes in each network but also yield a population-based common hub node map. Results of the accuracy and replicability on both synthetic and real network data show that the proposed manifold learning approach outperforms all hub identification methods employed in this evaluation. [ABSTRACT FROM AUTHOR]

In the field of connectomics, neuroscientists acquire electron microscopy volumes at nanometer resolution in order to reconstruct a detailed wiring diagram of the neurons in the brain. The resulting image volumes, which often are hundreds of terabytes in size, need to be segmented to identify cell boundaries, synapses, and important cell organelles. However, the segmentation process of a single volume is very complex, time-intensive, and usually performed using a diverse set of tools and many users. To tackle the associated challenges, this paper presents NeuroBlocks, which is a novel visualization system for tracking the state, progress, and evolution of very large volumetric segmentation data in neuroscience. NeuroBlocks is a multi-user web-based application that seamlessly integrates the diverse set of tools that neuroscientists currently use for manual and semi-automatic segmentation, proofreading, visualization, and analysis. NeuroBlocks is the first system that integrates this heterogeneous tool set, providing crucial support for the management, provenance, accountability, and auditing of large-scale segmentations. We describe the design of NeuroBlocks, starting with an analysis of the domain-specific tasks, their inherent challenges, and our subsequent task abstraction and visual representation. We demonstrate the utility of our design based on two case studies that focus on different user roles and their respective requirements for performing and tracking the progress of segmentation and proofreading in a large real-world connectomics project. [ABSTRACT FROM AUTHOR]

Generative adversarial networks (GANs) are subject to catastrophic forgetting when learning stream of data. Inspired by the knowledge of neuroscience, this article develops a memory formation system (MFS) to establish memory for GANs. MFS is composed of three modules, including the identifier, weights upgrade (WU), and weights reactivate (WR). These modules simulate the function of encoding, consolidating, and retrieving in memory formation of human. Identifier creates indexes to label continuous tasks and these indexes are used as a cue when the corresponding tasks are recalled. WU and WR work as synaptic consolidation and system consolidation, respectively. In WU, a novel method, weight saliency measure (WSM) is proposed to measure the saliency of weight. Valuable weights are protected and invaluable weights are released for update when GAN is trained for the new task. In WR, traditional data-replay methods are improved by selecting ${k}$ representatives in each class and their feature vectors are restored. When pseudo data of this class are regenerated, only the samples with distance less than a threshold can be used in future training. Experimental results based on the testing of continual image generation and continual 3-D reconstruction show that MFS can establish a memory system to handle the catastrophic forgetting problem effectively. [ABSTRACT FROM AUTHOR]

Spikes and rhythms organize control and communication in the animal world, in contrast to the bits and clocks of digital technology. As continuous-time signals that can be counted, spikes have a mixed nature. This article reviews ongoing efforts to develop a control theory of spiking systems. The central thesis is that the mixed nature of spiking results from a mixed feedback principle, and a control theory of mixed feedback can be grounded in the operator theoretic concept of maximal monotonicity. As a nonlinear generalization of passivity, maximal monotonicity acknowledges at once the physics of electrical circuits, the algorithmic tractability of convex optimization, and the feedback control theory of incremental passivity. We discuss the relevance of a theory of spiking control systems in the emerging age of event-based technology. [ABSTRACT FROM AUTHOR]

Brain functional connectivity estimation allows us to depict patterns of cerebral activity not understandable otherwise with the standard brain imaging techniques such as functional magnetic resonance imaging (fMRI) as well as electro or magnetoencephalography (hr-EEG, MEG). This special issue of the IEEE Transactions on Biomedical Engineering reports a range of methodological innovations toward the estimation of functional connectivity from brain activity data, with emphasis on neuroelectric and hemodynamic imaging modalities. Functional connectivity methodologies enable “connecting of the dots” derived from brain activity observations over multiple distributed sites, as depicted by such fMRI and hr-EEG/MEG devices. [ABSTRACT FROM PUBLISHER]

The papers in this special section is to focus on the deployment of haptics in the field of neuroscience. The neuroscience of haptics has made many breakthroughs over the last six or so decades and these scientific advances are now being leveraged to develop new therapies for patients suffering from sensorimotor disorders and new technologies to improve our everyday lives. This special section features a broad range of studies, some of which advance our basic understanding of haptics, others develop devices to further study haptics neuroscience, and still others invoke what is known about the neural basis of haptics to develop new therapeutic or augmentative devices. [ABSTRACT FROM PUBLISHER]

The papers in this special issue focus on the management of Parkinson's disease (PD). PD is the most common neurological movement disorder with a prevalence of up to 2% in the elderly. The cardinal motor symptoms bradykinesia, rigidity, tremor, and postural instability define the diagnosis of the PD. [ABSTRACT FROM PUBLISHER]