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Quantitative relations between topological similarity degree and map scale change of multi-scale contour clusters are vital to the automation of map generalization. However, no method has been proposed to calculate the relations. This paper aims at filling the gap by proposing a new approach. It firstly constructed a directed contour tree by pre-processing of unclosed contours, and then developed a quantitative expression of topological relations of contour cluster based on directed contour tree. After this, it employed 108 groups of multi-scale contour clusters with different geomorphological types to explore the changing regularity of topological indices with map scale. Last, it used 416 points to calculate the quantitative relations between topological similarity degree and map scale change by curve fitting method. The results show that the quantitative expression of multi-scale topological indexes is closely related to the contour interval change, and power function is the best fit among the candidate functions. [ABSTRACT FROM AUTHOR]