1. Next Stage Approach to Tissue Engineering Skeletal Muscle.
- Author
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Reid, Gregory, Magarotto, Fabio, Marsano, Anna, and Pozzobon, Michela
- Subjects
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TISSUE engineering , *SKELETAL muscle , *MUSCLE injuries , *VESICLES (Cytology) , *GROWTH factors - Abstract
Large-scale muscle injury in humans initiates a complex regeneration process, as not only the muscular, but also the vascular and neuro-muscular compartments have to be repaired. Conventional therapeutic strategies often fall short of reaching the desired functional outcome, due to the inherent complexity of natural skeletal muscle. Tissue engineering offers a promising alternative treatment strategy, aiming to achieve an engineered tissue close to natural tissue composition and function, able to induce long-term, functional regeneration after in vivo implantation. This review aims to summarize the latest approaches of tissue engineering skeletal muscle, with specific attention toward fabrication, neuro-angiogenesis, multicellularity and the biochemical cues that adjuvate the regeneration process. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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