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This paper collects and analyzes the 1954–2017 monthly average reanalysis data from the U.S. National Centers for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR), the 1954–2017 haze days observation data from the National Meteorological Information Center/China Meteorological Administration (NMIC/CMA) and the PM2.5 daily average mass concentration data in 2013–2017 from the China Air Quality Online Monitoring Platform. The atmospheric apparent heat source Q1 (negative Q1 means cold source in winter) over the Tibetan Plateau in December of 1954–2017 is estimated based on thermodynamic equations, and the East Asian winter monsoon index (EAWMI) is calculated. In addition, the discrepancies of the air quality among China's five typical regions (Beijing–Tianjin–Hebei, Fen-Wei Plain, Yangtze River Delta, Pearl River Delta and Sichuan-Chongqing regions) under the joint influence of the Q1 and EAWMI are studied. Results show that when it is a strong cold source year, abnormal downdrafts and "temperature inversion covers" occur in areas far from the high terrain, resulting in increased pollution, while the opposite is true in weak cold source years. In strong EAWMI years, there is an abnormal northerly sinking cold flow in the lower layers of mid-high latitudes, which increases the pollution in the area south of 30° N, and the opposite is true in weak EAWMI years. Affected by the combined activities of the Q1 and the EAWMI, the meteorological conditions of the five typical regions are different, and thus present different air pollution characteristics. [ABSTRACT FROM AUTHOR]