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Modular construction is gaining worldwide attention. Building services are the systems that make buildings comfortable and efficient. Mechanical, electrical, and plumbing (MEP) systems provide heating, cooling, lighting, energy distribution, and water services. Modular construction integrates building services into prefabricated modules at the manufacturing site, which are then transported to the construction site. A systematic review (SR) of building services integration within modular construction is thus necessary. Prior to the SR, a quantitative analysis of the retrieved 115 publications from the Scopus database was explored. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guide, 13 relevant publications from the Scopus database and via the Research Rabbit application were profiled. MEP systems integration approaches and research needs were examined. Recent literature emphasizes technology integration and sustainability, while early studies laid the framework for modular approaches. The findings highlight the potential of digital technologies like building information modeling (BIM) and recommend a holistic framework for the entire building's lifetime, from design to operation. Future research directions include performance studies, modular building service adaptation, and industry-wide standards building. Researchers and practitioners seeking to improve modular construction methods and integrate complex building services will gain insights from this study. [ABSTRACT FROM AUTHOR]

Active learning has been increasingly important in tertiary education in recent years due to its powerfully favourable impact on students' learning attitudes and efficacy. Indeed, the way that a classroom is set up has a direct impact on how well students learn and how well teachers teach. The continuous evaluation of students' learning performance is essential for guiding future classroom renovations and creating a cutting-edge learning environment for both students and teachers. The aims of this paper were to provide a better understanding of the latest development trend of learning mode preference in tertiary education and to investigate any underlying similarities and differences in the perceptions between teachers and students. To support both teaching and learning, an empirical questionnaire survey was conducted among teachers and students in Hong Kong to assess the effectiveness of various active learning techniques and passive learning techniques adopted in tertiary education. Opinion-based data were collected on the perceived benefits and disadvantages of both learning techniques as well as the importance of various classroom design features. To determine the significance of the variations in opinions between teachers and students on the survey responses, descriptive statistical analyses using the mean score and Mann–Whitney U-test were carried out. The results of the Mann–Whitney U-test on the advantages of traditional learning showed that the following variables significantly varied: 'direct information from the teacher'; 'timesaving (group discussion may waste time)' and 'allow more time for Q&A'. These advantages were generally rated higher from the viewpoint of students rather than teachers. However, no significant difference was established concerning the limitations of traditional learning. The findings of this study can help teachers and instructors to understand how different teaching and learning methods affect students' ability to learn effectively, which can ultimately help institutional policymakers to determine the necessary essential requirements for orchestrating classroom designs to create more conducive teaching and learning environments. The findings also aim to inform policymakers and educational institutions on the impact of pedagogical change on the fundamental design requirements for a flexible classroom environment supportive of students' active learning, especially in tertiary education. [ABSTRACT FROM AUTHOR]

Vaccines play an important role in maintaining human and animal health worldwide. There is continued demand for effective and safe adjuvants capable of enhancing antigen-specific responses to a target pathogen. Rabbit hemorrhagic disease virus (RHDV) is a highly contagious calicivirus that often induces high mortality rates in rabbits. Herein, we evaluated the activity of an experimental sulfated lactosyl archaeol (SLA) archaeosome adjuvant when incorporated in subunit vaccine formulations targeting RHDV. The subunit antigens consisted of RHDV–CRM197 peptide conjugates or recombinant RHDV2 VP60. SLA was able to enhance antigen-specific antibody titers and cellular responses in mice and rabbits. Three weeks following immunization, antigen-specific antibody levels in rabbits vaccinated with RHDV2 VP60 + SLA were significantly higher than those immunized with antigen alone, with geomean titers of 7393 vs. 117. In addition, the SLA-adjuvanted VP60-based formulations were highly efficacious in a rabbit RHDV2 challenge model with up to 87.5% animals surviving the viral challenge. These findings demonstrate the potential utility of SLA adjuvants in veterinary applications and highlight its activity in different types of mammalian species. [ABSTRACT FROM AUTHOR]

The world is currently facing a global health crisis due to the rapid increase in antimicrobial-resistant bacterial infections. One of the most concerning pathogens is Acinetobacter baumannii, which is listed as a Priority 1 pathogen by the World Health Organization. This Gram-negative bacterium has many intrinsic antibiotic resistance mechanisms and the ability to quickly acquire new resistance determinants from its environment. A limited number of effective antibiotics against this pathogen complicates the treatment of A. baumannii infections. A potential treatment option that is rapidly gaining interest is "phage therapy", or the clinical application of bacteriophages to selectively kill bacteria. The myoviruses DLP1 and DLP2 (vB_AbaM-DLP_1 and vB_AbaM-DLP_2, respectively) were isolated from sewage samples using a capsule minus variant of A. baumannii strain AB5075. Host range analysis of these phages against 107 A. baumannii strains shows a limited host range, infecting 15 and 21 for phages DLP1 and DLP2, respectively. Phage DLP1 has a large burst size of 239 PFU/cell, a latency period of 20 min, and virulence index of 0.93. In contrast, DLP2 has a smaller burst size of 24 PFU/cell, a latency period of 20 min, and virulence index of 0.86. Both phages show potential for use as therapeutics to combat A. baumannii infections. [ABSTRACT FROM AUTHOR]

Cationic nanomaterials are promising candidates for the development of effective antibacterial agents by taking advantage of the nanoscale effects as well as other exceptional physicochemical properties of nanomaterials. In this study, carboxylated cellulose nanocrystals (cCNCs) derived from softwood pulp were coated with cationic poly(diallyldimethylammonium chloride) of varying molecular weights. The resulting cationic carboxylated cellulose nanocrystals coated with poly(diallyldimethylammonium chloride) (cCNCs–PDDA) nanomaterials were characterized for their structural and morphological properties using Fourier transform infrared spectroscopy, dynamic light scattering, zeta potential, elemental analysis, transmission electron microscopy, and thermogravimetric analysis. Cationic cCNCs–PDDA were investigated for their antibacterial properties against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli 23934 and Pseudomonas aeruginosa using a bacterial lawn growth inhibition assay. cCNC–PDDA materials displayed marked antibacterial activity, particularly against Gram-positive Staphylococcus aureus. Overall, our results indicated that cCNCs–PDDA could be a potential candidate for antibacterial applications such as antibacterial surfaces or coatings. [ABSTRACT FROM AUTHOR]

This research paper assesses the effectiveness of conducting heritage revitalization projects on improving community planning and identifies the advancements and revitalization trends of heritage revitalization in Hong Kong. The study proposes three indicators to judge the effectiveness of heritage revitalization, including attractive appearance and components, creative methods of building techniques and planning, and public acceptance. A case study is adopted to analyze the shortcomings and improvements of the effectiveness of heritage revitalization, along with a comprehensive literature review and statistics related to heritage revitalization in Hong Kong. The results indicated that revitalization is able to effectively modify the outlook of the community and even improve community planning in the future in terms of transportation services, supporting facilities, and living quality. Moreover, by considering the revitalized structure, modern elements and building rehabilitation strategies were included to increase its attractiveness to become emerging tourism spots for business activities. Heritage revitalization practices have been carried out in Hong Kong in the recent decade. The study embarks to identify and analyze the advancements of revitalization development and its revitalizing style reformation by means of the cases recently completed in Hong Kong, which brings insights to academics and policy makers of revitalization in community planning. [ABSTRACT FROM AUTHOR]

In recent years, cellulose nanocrystals (CNCs) have emerged as a leading biomass-based nanomaterial owing to their unique functional properties and sustainable resourcing. Sulfated cellulose nanocrystals (sCNCs), produced by sulfuric acid-assisted hydrolysis of cellulose, is currently the predominant form of this class of nanomaterial; its utilization leads the way in terms of CNC commercialization activities and industrial applications. The functional properties, including high crystallinity, colloidal stability, and uniform nanoscale dimensions, can also be attained through carboxylated cellulose nanocrystals (cCNCs). Herein, we review recent progress in methods and feedstock materials for producing cCNCs, describe their functional properties, and discuss the initial successes in their applications. Comparisons are made to sCNCs to highlight some of the inherent advantages that cCNCs may possess in similar applications. [ABSTRACT FROM AUTHOR]

Cancer remains a leading cause of morbidity and mortality worldwide. While novel treatments have improved survival outcomes for some patients, new treatment modalities/platforms are needed to combat a wider variety of tumor types. Cancer vaccines harness the power of the immune system to generate targeted tumor-specific immune responses. Liposomes composed of glycolipids derived from archaea (i.e., archaeosomes) have been shown to be potent adjuvants, inducing robust, long-lasting humoral and cell-mediated immune responses to a variety of antigens. Herein, we evaluated the ability of archaeosomes composed of sulfated lactosyl archaeol (SLA), a semi-synthetic archaeal glycolipid, to enhance the immunogenicity of a synthetic long peptide-based vaccine formulation containing the dominant CD8+ T cell epitope, SIINFEKL, from the weakly immunogenic model antigen ovalbumin. One advantage of immunizing with long peptides is the ability to include multiple epitopes, for example, the long peptide antigen was also designed to include the immediately adjacent CD4+ epitope, TEWTSSNVMEER. SLA archaeosomes were tested alone or in combination with the toll-like receptor 3 (TLR3) agonist Poly(I:C). Overall, SLA archaeosomes synergized strongly with Poly(I:C) to induce robust antigen-specific CD8+ T cell responses, which were highly functional in an in vivo cytolytic assay. Furthermore, immunization with this vaccine formulation suppressed tumor growth and extended mouse survival in a mouse melanoma tumor model. Overall, the combination of SLA archaeosomes and Poly(I:C) appears to be a promising adjuvant system when used along with long peptide-based antigens targeting cancer. [ABSTRACT FROM AUTHOR]

Archaeosomes, composed of sulfated lactosyl archaeol (SLA) glycolipids, have been proven to be an effective vaccine adjuvant in multiple preclinical models of infectious disease or cancer. SLA archaeosomes are a promising adjuvant candidate due to their ability to strongly stimulate both humoral and cytotoxic immune responses when simply admixed with an antigen. In the present study, we evaluated whether the adjuvant effects of SLA archaeosomes could be further enhanced when combined with other adjuvants. SLA archaeosomes were co-administered with five different Toll-like Receptor (TLR) agonists or the saponin QS-21 using ovalbumin as a model antigen in mice. Both humoral and cellular immune responses were greatly enhanced compared to either adjuvant alone when SLA archaeosomes were combined with either the TLR3 agonist poly(I:C) or the TLR9 agonist CpG. These results were also confirmed in a separate study using Hepatitis B surface antigen (HBsAg) and support the further evaluation of these adjuvant combinations. [ABSTRACT FROM AUTHOR]

Traditional teaching modes are engaged with teachers delivering knowledge to students with minimum feedback. Teaching is conducted in lecture theaters and classrooms, which are sometimes designed with minimum flexibility for university education. However, the rapid development of information and communication technologies has altered the teaching pedagogy from traditionally teacher-centered to more collaborative learning between teachers and students. Learning spaces should be designed to be interactive and collaborative with suitable physical movement and social engagement among teachers and students. This paper aims to examine the relationships between modern technology and pedagogical shift, and to identify and discuss the essential design principles for effective active learning through built pedagogy. A recent renovation project of The Hong Kong Polytechnic University in converting conventional classrooms and lecture theaters to active learning spaces was adopted as a case study to illustrate and validate the design principles and their actual implementation. Feedback and responses from 410 end-user students on the impact of the renovated classrooms and lecture theaters on teaching and learning effectiveness were gleaned through empirical survey questionnaires dispatched face-to-face to students after attending classes in the renovated classrooms and lecture theaters. The results of factor analysis indicated that the 15 variables of key design criteria for active learning spaces were consolidated under six underlying clustered factor groups: (1) Versatility of learning space; (2) interior design of learning environment; (3) modern information technology / audio and video (IT/AV) technologies; (4) interior lighting; (5) comfortable furniture and acoustic design; and (6) interior temperature. The survey findings can serve as good references and useful insights for architects in designing new learning spaces and facilities that assist active and collaborative learning for university students in future. [ABSTRACT FROM AUTHOR]