1. An On-Demand Dissoluble Chitosan Hydrogel Containing Dynamic Diselenide Bond
- Author
-
Pan Xiangqiang, Jian Zhu, Xiulin Zhu, Weihong Lu, and Xingxia Xu
- Subjects
Materials science ,Polymers and Plastics ,Biocompatibility ,chemistry.chemical_element ,Bioengineering ,02 engineering and technology ,macromolecular substances ,01 natural sciences ,complex mixtures ,Article ,Biomaterials ,Chitosan ,Diselenide ,lcsh:Chemistry ,chemistry.chemical_compound ,X-ray photoelectron spectroscopy ,lcsh:General. Including alchemy ,lcsh:Inorganic chemistry ,lcsh:Science ,Dissolution ,diselenide ,010405 organic chemistry ,Organic Chemistry ,technology, industry, and agriculture ,021001 nanoscience & nanotechnology ,lcsh:QD146-197 ,0104 chemical sciences ,on-demand dissolution ,chemistry ,Chemical engineering ,lcsh:QD1-999 ,Proton NMR ,Degradation (geology) ,lcsh:Q ,chitosan ,hydrogel ,0210 nano-technology ,Selenium ,lcsh:QD1-65 - Abstract
A new kind of on-demand dissolution hydrogel is successfully synthesized by modification of chitosan using γ-selenobutyrolactone. The chitosan hydrogel with different selenium contents is formed by ring opening of γ-selenobutyrolactone with the amines of D-glucosamine units on the chitosan backbone. The structure of the hydrogel was confirmed by 1H NMR, XRD and XPS. Its physical and biological properties were evaluated by rheology characterization, degradation tests and cytotoxicity test. The hydrogel showed excellent biocompatibility and good degradation properties under oxidation or reduction conditions. All the evidence demonstrated that this type of material has good prospects for dressing applications.
- Published
- 2021