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The presence or absence of terminal sialic acid residues in the sugar moiety attached to the Fc-domain of IgG molecules modulates IgG activity and is associated with autoimmune or infection related inflammation. In a recent paper, Oswald and colleagues suggest that IgG sialylation may occur post IgG secretion from plasma cells, which would be a major issue for therapeutic antibodies injected into patients. In contrast, we argue that previous work rather demonstrates that IgG sialylation occurs within B cells and that the experimental system used by the authors is not suitable to address this critical question. [ABSTRACT FROM AUTHOR]

I International Immunology i , dxab111, https://doi.org/10.1093/intimm/dxab111 After this paper was accepted, the authors realized that the data in the middle and bottom histograms of Fig. 3C and the right-hand flow cytometry plot of Fig. [Extracted from the article]