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Summary: Adjuvants, as the name indicates, are adjoined material aimed to assist in functioning as when added to vaccines they are meant to boost the effect and strongly stimulate the immune system. The response of the immune system can be unpredictable, and the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was developed to address possible adverse reactions of an autoimmune and inflammatory type that may be caused by adjuvants. While ASIA, as a syndrome, was coined and defined in 2011; reports describing patients with vague and nonspecific clinical symptoms following vaccinations appeared much earlier. In other words, ASIA came to define, arrange, and unite the variety of symptoms, related to autoimmunity, caused not by the vaccine itself, rather by the adjuvant part of the vaccine such as aluminum, among others. Accordingly, the introduction of ASIA enabled better understanding, proper diagnosis, and early treatment of the disorder. Furthermore, ASIA was shown to be associated with almost all body systems and various rheumatic and autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, and systemic sclerosis. In addition, the correlation between COVID-19 and ASIA was noticed during the pandemic. In this review, we summarized the reported effects of adjuvants and medical literature before and after ASIA was defined, the several ways ASIA can manifest and impact different systems of the body, and the incidences of ASIA during the COVID-19 pandemic. It is important to clarify, that vaccines are among, if not the, most effective means of fighting infectious diseases however, we believe that vaccines manufacturing is not above criticism, particularly when it comes to added substances possessing a risk of side effects. Adjuvants such as aluminum, mineral oils, and silicone are added to vaccines in order to trigger a stronger immune response. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was introduced in 2011 to address nonspecific symptoms and disorders appearing following vaccinations, which in fact were reported by many papers before the introduction of the syndrome. During the pandemic of COVID-19, a correlation between ASIA, COVID-19, and COVID-19 vaccines has been reported. [ABSTRACT FROM AUTHOR]

This paper examines the relationship between urban agglomeration and firm innovation using a recently developed dataset that consistently measures city boundaries across Asia together with geo-referenced firm-level data. It finds that the spatial distribution of innovation by firms is highly concentrated within countries. Further, firms in larger cities have substantially higher propensities to introduce product and process innovations and to undertake R&D activities, a result that holds for subgroups of countries and even when the largest cities are excluded from the analysis. Finally, the presence of high-quality universities and highly ranked engineering departments in cities is positively associated with firm innovation, lending support to the idea that the accumulation of human capital locally is a key channel through which urban agglomeration affects innovation. [ABSTRACT FROM AUTHOR]

The earliest Crocodylia from Asia have been represented so far only by alligatoroids and planocraniids. Although definitive crocodyloids are not known until the late Eocene, it has been hypothesized that Asiatosuchus -like basal crocodyloids originated in Asia before the late Palaeocene. In this paper, we describe a new fossil crocodyloid from the lower Palaeocene of Qianshan Basin, Anhui Province, China. The skull and lower jaw fragment exhibit several characteristics typical of juvenile crocodylians. They also display a combination of features not seen in any other taxon, warranting the erection of a new species and genus, Qianshanosuchus youngi gen. & sp. nov. Its affinities are tested in phylogenetic analyses based on two recent character matrices of Eusuchia. To assess the effect of juvenile characteristics on the outcome of the phylogenetic analyses, juvenile specimens of extant crocodylian taxa are analysed in the same way, showing that the effect of their ontogenetic stage on their placement in the tree is minimal. Our analyses point to a basal crocodyloid position for Q. youngi. With these findings, the presence of Crocodyloidea in Asia is extended to the early Palaeocene, 15–20 Myr earlier than formerly thought. Furthermore, our results corroborate previous hypotheses of a Palaeocene dispersal route of Asiatosuchus -like crocodyloids from Asia into Europe. [ABSTRACT FROM AUTHOR]

Introduction Disaster epidemiological studies indicate that Asia has the highest frequency of natural disasters. Rural communities are heavily impacted by natural disasters and have different healthcare needs to urban ones. Referencing Asian countries, this paper's objective is to provide an overview of health impacts and the current evidence for designing programmes and policies related to rural health emergency and disaster risk management (health-EDRM). Sources of data This paper uses published English-only reports and papers retrieved from PubMed, Google Scholar, Embase, Medline and PsycINFO on rural disaster and emergency responses and relief, health impact and disease patterns in Asia (January 2000–January 2018). Areas of agreement Earthquakes are the most studied natural disasters in rural communities. The medical burden and health needs of rural communities were most commonly reported among populations of extreme age. Most of the existing research evidence for rural interventions was reported in China. There lacks published peer-reviewed reports of programme impacts on personal and community preparedness. Areas of controversy There is a lack of evidence-based health-EDRM interventions to evaluate implementation effectiveness in rural areas despite vast volumes of health-related disaster literature. Growing points Climate change-related disasters are increasing in frequency and severity. Evidence is needed for disaster risk reduction interventions to address the health risks specific to rural populations. Areas timely for developing research To support global policy development, urgent evidence is needed on the intervention effectiveness, long-term health outcomes, local and cultural relevance as well as sustainability of health relief produced by Health-EDRM programmes in rural areas. [ABSTRACT FROM AUTHOR]

This paper asks what insights the literature provides on divergence versus convergence of innovation paths in Europe and Asia. It contrasts the abundant literature on determinants of innovation paths with the scarcity of studies that are explicitly comparative across countries or continents. Implicit conclusions however emerge from several lines of work including evolutionary perspectives which stress differences in national conditions, and other perspectives which stress latecomer and globalisation effects. This paper distils and draws together the main conclusions on why innovation paths can be expected to diverge or converge. Its contribution lies in spelling out and bringing together implicit and explicit insights from a wide range of literatures. It also provides an analytical backdrop for some of the other papers in this special issue of Science and Public Policy which provide comparative empirical analyses of low carbon innovation paths. [ABSTRACT FROM AUTHOR]

Antimicrobial resistance (AMR) is a multifaceted global health problem disproportionately affecting low- and middle-income countries (LMICs). The Capturing data on Antimicrobial resistance Patterns and Trends in Use in Regions of Asia (CAPTURA) project was tasked to expand the volume of AMR and antimicrobial use data in Asia. The CAPTURA project used 2 data-collection streams: facility data and project metadata. Project metadata constituted information collected to map out data sources and assess data quality, while facility data referred to the retrospective data collected from healthcare facilities. A down-selection process, labelled "the funnel approach" by the project, was adopted to use the project metadata in prioritizing and selecting laboratories for retrospective AMR data collection. Moreover, the metadata served as a guide for understanding the AMR data once they were collected. The findings from CAPTURA's metadata add to the current discourse on the limitation of AMR data in LMICs. There is generally a low volume of AMR data generated as there is a lack of microbiology laboratories with sufficient antimicrobial susceptibility testing capacity. Many laboratories in Asia are still capturing data on paper, resulting in scattered or unused data not readily accessible or shareable for analyses. There is also a lack of clinical and epidemiological data captured, impeding interpretation and in-depth understanding of the AMR data. CAPTURA's experience in Asia suggests that there is a wide spectrum of capacity and capability of microbiology laboratories within a country and region. As local AMR surveillance is a crucial instrument to inform context-specific measures to combat AMR, it is important to understand and assess current capacity-building needs while implementing activities to enhance surveillance systems. [ABSTRACT FROM AUTHOR]

In response to the global threat of antimicrobial resistance (AMR), the Capturing Data on Antimicrobial Resistance Patterns and Trends in Use in Regions of Asia (CAPTURA) project worked with microbiology laboratories, pharmacies, and local governments in South Asia and Southeast Asia to expand the volume of historical and current data available on AMR and antimicrobial use and to identify gaps in data and areas for quality improvement. When the CAPTURA project completed its country-level engagement in the first half of 2022, the consortium brought together local, regional, and global AMR stakeholders for a virtual regional workshop to review data outputs from the project and share strategies to inform national and regional efforts to combat AMR. This paper summarizes the main topics presented in the workshop held from 28 to 30 June 2022. As such, it highlights lessons learned from the project and strategies to fight AMR. Although CAPTURA has been invaluable to countries and information from the project is already being used, barriers concerning data quality and sharing remain. Regional-level initiatives should continue to build on the momentum gained from the CAPTURA project in supporting national-level surveillance and data quality improvements to inform critical decisions around planning, policies, and clinical care. Project findings have highlighted that issues with antimicrobial resistance and use are wide ranging across countries. Going forward, building on the current foundations and tailoring approaches to meet local needs and capacities will be fundamental in combatting AMR. [ABSTRACT FROM AUTHOR]

The increasing trends in antimicrobial resistance (AMR) continue to pose a significant threat to human health, with grave consequences in low- and middle-income countries. In collaboration with local governments and microbiology laboratories in South Asian and Southeast Asian countries, the Capturing Data on Antimicrobial Resistance Patterns and Trends in Use in Regions of Asia (CAPTURA) project worked to identify gaps and expand the volume of existing AMR data to inform decision-makers on how to best strengthen their national AMR surveillance capacity. This article describes overall project management processes and the strategies implemented to address the disruptive impact of the coronavirus disease 2019 (COVID-19) pandemic on the project activities across diverse contexts in different countries. Also, it assesses in-country team's feedback on the conduct of activities and their overall impact on project completion. The strategies employed were tailored to the specific context of each country and included increased communication and collaboration among consortium partners and in-country teams, as well as hiring of additional in-country team members. This paper highlights the importance of local representation and capacities as well as real-time (virtual) engagement with stakeholders, ensuring close monitoring of the local situation and ability to tailor context-specific mitigation strategies to continue project implementation during disruptive external circumstances. [ABSTRACT FROM AUTHOR]

The emergence of coronavirus disease-2019 (COVID-19) pandemic has stimulated governments to an extensive discussion on the necessity of COVID-19 vaccination certificate (CVC) to help monitor and manage the rollout of vaccinations and revive the economy. A recent correspondence highlighted the ethical issues concerning COVID-19 diagnostic test results and vaccination certificates. This paper highlights the potential benefits and harms of implementing CVC in the ASEAN region. [ABSTRACT FROM AUTHOR]

The reward system in academic science has changed rapidly in recent years, as many universities especially in Asia and Europe implemented new incentive systems based on research performance. To understand the relationship between inequality in science and the performance-based incentives, this study examined the influence of incentives for publications on not only research performance, but also the distribution of research performance in a Korean university. The findings of this study suggest that using a carefully designed performance incentive system, research organizations may reduce inequality in scientists' research performance while increasing their overall performance. The reduced inequality was due mainly to lower ranking researchers improving their publication performance. Meanwhile, top-ranked researchers responded only to incentives for the quality of publications. We interpret the change in research performance as an outcome of complicated interactions among the structure of incentive systems, scientists' diverse motivations, and their position in the stratification in science. [ABSTRACT FROM AUTHOR]

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This paper has three parts. The first outlines the history of Nestorianism. From the end of the fifth century all the way into the thirteenth century (c. e.), quite a large population—in fact most Christians in Asia—belonged to branches of the Nestorian church. The second part provides a brief biography of Nestorius, after whom this church was named. The third part explores two elements of Nestorius's christology, as they are found in his posthumously discovered theological writings. (1) Does Christ have one nature or two (both human and divine), and if two, how can one person have two natures? (2) To what extent was Adam, the first man, created for a role that Christ eventually fulfilled? [ABSTRACT FROM AUTHOR]

Tapinoma indicum (Forel) (Hymenoptera: Formicidae) is a nuisance pest in Asia countries. However, studies on T. indicum are limited, especially in the field of molecular biology, to investigate the species characteristic at the molecular level. This paper aims to provide valuable genetic markers as tools with which to study the T. indicum population. In this study, a total of 143,998 microsatellite markers were developed based on the 2.61 × 106 microsatellites isolated from T. indicum genomic DNA sequences. Fifty selected microsatellite markers were amplified with varying numbers of alleles ranging from 0 to 19. Seven out of fifty microsatellite markers were characterized for polymorphism with the Hardy–Weinberg equilibrium (HWE) and linkage disequilibrium (LD) analysis. All seven microsatellite markers demonstrated a high polymorphic information content (PIC) value ranging from 0.87 to 0.93, with a mean value of 0.90. There is no evidence of scoring errors caused by stutter peaks, no large allele dropout, and no linkage disequilibrium among the seven loci; although loci Ti-Tr04, Ti-Tr09, Ti-Te04, Ti-Te13, and Ti-Pe5 showed signs of null alleles and deviation from the HWE due to excessive homozygosity. In conclusion, a significant amount of microsatellite markers was developed from the data set of next-generation sequencing, and seven of microsatellite markers were validated as informative genetic markers that can be utilized to study the T. indicum population. [ABSTRACT FROM AUTHOR]

Infant massage is a highly prevalent traditional practice in India and other parts of Asia. Clear guidance on safe and effective uses of infant massage is lacking especially in the contemporary times when the traditional knowledge is on the verge of extinction and preparations may differ from in the past. This paper presents a consensus guidance in the form of a standardized protocol for routine massage of infants in home settings. Furthermore, a feasible method to develop an integrative protocol involving traditional and modern medicine experts is described. A modified e-Delphi method was used to develop the protocol. A group of seventeen experts, including academicians and practitioners from disciplines as modern paediatrics, Ayurveda paediatrics, Physiotherapy and Naturopathy participated in three rounds of a Delphi study to evolve the consensus guidance. The present protocol for massage of infants born beyond 34 weeks of gestation and weighing above 1.8 kg is recommended for use by care givers. This provides guidance on the preparation for infant massage such as when to begin massaging the infant, checking fitness of the infant for massage, the appropriate time, environment, person and substance for infant massage and a detailed description of the procedure for infant massage. Paediatricians, obstetricians and other child care practitioners can use this protocol to guide care givers on how to peform infant massage. [ABSTRACT FROM AUTHOR]

The Western Pacific Region is the largest and most diverse region in the world, made up of 37 countries and territories in the Pacific, Oceania and parts of Asia, with a population of more than 1.9 billion people stretching over an area from China and Mongolia in the north to New Zealand in the south. In 1999, 22 countries and territories in the Pacific joined together and launched the Pacific Programme to Eliminate Lymphatic Filariasis. Shortly after, the Global Programme to Eliminate Lymphatic Filariasis was launched in 2000. In 2004, 12 countries in the Asia subregion of the Western Pacific Region and Southeast Asian Region joined and developed the Mekong-Plus Strategic Plan for Elimination of Lymphatic Filariasis. Since then, significant efforts have been made by all endemic countries, with annual mass drug administration (MDA) as a principal strategy, through strong partnership with the WHO and other donors and partners. As a result, by the end of 2019, 10 of 22 endemic countries in the region, including 8 of 16 countries in the Pacific and 2 countries in the Asia subregion, achieved WHO validation for elimination of lymphatic filariasis (LF) as a public health problem. All the other countries are either progressing with post-MDA surveillance or accelerating efforts by adoption of the new triple drug therapy strategy and enhancement of MDA campaigns to tackle persistent transmission. Some 85% of the originally endemic implementation units have stopped MDA and the number of people requiring MDA for LF in the Western Pacific Region was reduced by 72% from 2000 to 2018. This paper reviews the progress, key success factors and remaining challenges and indicates the way forward to achieve LF elimination in the Western Pacific Region. [ABSTRACT FROM AUTHOR]

In this paper, convolutional neural networks (CNNs) were used to distinguish between tectonic and non-tectonic seismicity. The proposed CNNs consisted of seven convolutional layers with small kernels and one fully connected layer, which only relied on the acoustic waveform without extracting features manually. For a single station, the accuracy of the model was 0.90, and the event accuracy could reach 0.93. The proposed model was tested using data from January 2019 to August 2019 in China. The event accuracy could reach 0.92, showing that the proposed model could distinguish between tectonic and non-tectonic seismicity. [ABSTRACT FROM AUTHOR]

In recent years, the study of the networks, ideas and identities that bound the 'British world' together has proved a rich field of enquiry in imperial history. This article seeks to apply those insights to an issue that dominated much of Britain's relations with its settler colonies before the First World War: the controversies surrounding the exclusion of Asian migrants. Racial exclusion has garnered a great deal of scholarly attention in recent years. This article builds on that historiography, but also questions its inattention to the British connection, and hence to considerations of imperial power. It analyses how the debate on immigration served as a canvas on which advocates and detractors of exclusion could paint competing concepts of empire, and seeks to understand how policymakers attempted to manage the migration question through a range of spatial and diplomatic solutions. It will attempt, in sum, to show how a global empire dealt with the problems of a world that seemed increasingly divided along racial lines. [ABSTRACT FROM AUTHOR]

The article offers information on a workshop at the 16th World Congress on Public Health 2020 about vaccination challenges in developed and developing countries.

This paper presents the results of the evaluation of the uncertainty in measurement of the personal dose equivalent, Hp (10), at nine individual monitoring services (IMSs) in Asia and the Pacific region. Different types of passive dosemeters were type-tested according to the International Electrotechnical Commission 62387 requirements. The uncertainty in measurement was calculated using the Guide to the Expression of Uncertainty in Measurement approach. Expanded uncertainties ranged between 24 and 86% (average = 38%) for Hp (10) values around 1 mSv and between 14 and 40% (average = 27%) for doses around the annual dose limit, Hp (10) = 20 mSv. The expanded uncertainties were lower than the 1.5 factor in either direction proposed by the International Commission on Radiological Protection for doses near the relevant dose limits. This indicates an acceptable level of uncertainty for all participating IMSs. Uncertainty evaluation will help the IMSs to acknowledge the accuracy of their measurements. [ABSTRACT FROM AUTHOR]

This paper reviews recent advances regarding land–atmosphere–ocean coupling associated with the Tibetan Plateau (TP) and its climatic impacts. Thermal forcing over the TP interacts strongly with that over the Iranian Plateau, forming a coupled heating system that elevates the tropopause, generates a monsoonal meridional circulation over South Asia and creates conditions of large-scale ascent favorable for Asian summer monsoon development. TP heating leads to intensification and westward extension (northward movement) of the South Asian High (Atlantic Intertropical Convergence Zone), and exerts strong impacts on upstream climate variations from North Atlantic to West Asia. It also affects oceanic circulation and buoyancy fields via atmospheric stationary wave trains and air–sea interaction processes, contributing to formation of the Atlantic Meridional Overturning Circulation. The TP thermal state and atmospheric–oceanic conditions are highly interactive and Asian summer monsoon variability is controlled synergistically by internal TP variability and external forcing factors. [ABSTRACT FROM AUTHOR]

Downward continuation is a very useful technique in the interpretation of potential field data. It would enhance the short wavelength of the gravity anomalies or accentuate the details of the source distribution. Taylor series expansion method has been proposed to be one of the best downward continued methods. However, the method using high-order vertical derivatives leads to low accuracy and instability results in many cases. In this paper, we propose a new method using a combination of Taylor series expansion and upward continuation for computing vertical derivatives. This method has been tested on the gravitational anomaly of infinite horizontal cylinder in both cases with and without random noise for higher accurate and stable than Hilbert transform method and Laplace equation method, especially in the case of noise input data. This vertical derivative method is applied successfully to calculate the downward continuation according to Taylor series expansion method. The downward continuation is also tested on both complex synthetic models and real data in the East Vietnam Sea (South China Sea). The results reveal that by calculating this new vertical derivative, the downward continuation method gave higher accurate and stable than the previous downward continuation methods. [ABSTRACT FROM AUTHOR]

Background: The World Health Organization (WHO) released a position paper in March 2018 calling for integration of a novel typhoid conjugate vaccine (TCV) into routine immunization along with catch-up campaigns for children up to age 15. Gavi, the Vaccine Alliance, has committed funding to help resource-constrained countries introduce this vaccine. In this article, the Typhoid Vaccine Acceleration Consortium forecasts demand if WHO recommendations are followed. Methods: We built a model of global TCV introductions between 2020 and 2040 to estimate the demand of the vaccine for 133 countries. We estimated each country's year of introduction by examining its estimated incidence of typhoid fever, its history of introducing new vaccines, and any knowledge we have of its engagement with typhoid prevention, including intention to apply for Gavi funding. Our model predicted use in routine infant vaccination as well as campaigns targeting varying proportions of the unvaccinated population up to 15 years of age. Results: Between 2020 and 2025, demand will predominantly come from African countries, many receiving Gavi support. After that, Asian countries generate most demand until 2030, when campaigns are estimated to end. Demand will then track the birth cohort of participating countries, suggesting an annual routine demand between 90 and 100 million doses. Peak demand is likely to occur between 2023 and 2026, approaching 300 million annual doses if campaign implementation is high. Conclusions: In our analysis, target population for catch-up campaigns is the main driver of uncertainty. At peak demand, there is some risk of exceeding presently estimated peak production capacity. Therefore, it will be important to carefully coordinate introductions, especially when accompanied by campaigns targeting large proportions of the eligible population. [ABSTRACT FROM AUTHOR]

As a data-driven approach, the performance of deep learning models depends largely on the quantity and quality of the training data sets, which greatly limits the application of deep learning to tasks with small data sets. Unfortunately, sometimes we need to use limited small data sets to complete our tasks, such as distributed acoustic sensing (DAS) data denoising. However, using a small data set to train the network may cause overfitting, resulting in poor network generalization. To solve this problem, we propose an approach based on the combination of a generative adversarial network and a deep convolutional neural network. First, we used a small noise data set to train a generative adversarial network to generate synthetic noise samples, and then used these synthetic noise samples to augment the noise data set. Next, we used the augmented noise data set and the signal data set obtained through forward modelling to construct a synthetic training set. Finally, a denoising network based on a convolutional neural network was trained on the constructed synthetic training set. Experimental results show that the augmented data set can effectively improve the denoising performance and generalization ability of the network, and the denoising network trained on the augmented data set can more effectively reduce various kinds of noise in the DAS data. [ABSTRACT FROM AUTHOR]

Invasive species may occupy quite different environments in their invaded areas to native ones, which may intensively interfere with predicting potential distribution through ecological niche modeling (ENM). Here, we take the tomato leafminer Tuta absoluta Meyrick (Lepidoptera: Gelechiidae), a tomato pest, as an example to investigate this topic. We analyzed niche expansion, stability, unfilling, and Schoener's D by principal component analysis (PCA) ordination method to examine its realized niche shifts and to explore how ENM approaches are affected by niche shifts. We used 5 datasets: Asian, African, European, South American, and global occurrence records in this study. Results showed that high niche unfilling for the species' invaded areas in Asia (20%), Africa (12%), and Europe (37%), possibly due to T. absoluta being in the early stages of invasion. High niche expansion was observed in Asia (38%) and Europe (19%), implying that some European and Asian populations had reached new climatic areas. African niche had the most niche stability (94%) and was equivalent to the native one in climate space (PCA ordination method), but the n -dimensional climate space framework showed that they were different. When projecting the native model to Asia and Europe, the native model performed poorly, implying that the niche shifts affected the transferability of the native model. ENM based on global data outperformed than other models, and our results suggested that T. absoluta has a large potential distribution in Asia, Mexico, South Europe, the United States, and Australia. Meanwhile, we recommend updating ENMs based on the species' invasion stage. [ABSTRACT FROM AUTHOR]

A list of the books received is presented including "The New Science of Ageing" edited by Alan Walker, "Older Persons in Southeast Asia: An Emerging Asset" edited by Evi Nurvidya Arifin and Aris Ananta and "Resilience and Aging: Research and Practice" by Helen Lavtresky.

In 2013 Indonesia, the world's fourth most populous country, declared that it would provide affordable health care for all its citizens within seven years. This crystallised an ambition first enshrined in law over five decades earlier, but never previously realised. This paper explores Indonesia's journey towards universal health coverage (UHC) from independence to the launch of a comprehensive health insurance scheme in January 2014. We find that Indonesia's path has been determined largely by domestic political concerns – different groups obtained access to healthcare as their socio-political importance grew. A major inflection point occurred following the Asian financial crisis of 1997. To stave off social unrest, the government provided health coverage for the poor for the first time, creating a path dependency that influenced later policy choices. The end of this programme coincided with decentralisation, leading to experimentation with several different models of health provision at the local level. When direct elections for local leaders were introduced in 2005, popular health schemes led to success at the polls. UHC became an electoral asset, moving up the political agenda. It also became contested, with national policy-makers appropriating health insurance programmes that were first developed locally, and taking credit for them. The Indonesian experience underlines the value of policy experimentation, and of a close understanding of the contextual and political factors that drive successful UHC models at the local level. Specific drivers of success and failure should be taken into account when scaling UHC to the national level. In the Indonesian example, UHC became possible when the interests of politically and economically influential groups were either satisfied or neutralised. While technical considerations took a back seat to political priorities in developing the structures for health coverage nationally, they will have to be addressed going forward to achieve sustainable UHC in Indonesia. [ABSTRACT FROM AUTHOR]

The events surrounding COVID-19, combined with the mandatory quarantines widely imposed in Asia and Europe since the virus outbreak, have reignited discussion of the balance between individual rights and liberties and public health during epidemics and pandemics. This article analyses this issue from the perspectives of precaution and necessity. There is a difficult relationship between these two seemingly opposite principles, both of which are frequently invoked in this domain. Although the precautionary principle (PP) encourages the use of quarantines, including mandatory quarantines, and associated restrictive measures, the principle of necessity (PN) puts a break on such measures. The COVID-19 pandemic reveals once again the different interrelations between these two principles. However, the alleged conflict between the PN and the PP is based on a superficial analysis. The relation between these two principles is far more complex, as this article will demonstrate. [ABSTRACT FROM AUTHOR]

Background Accurate estimation of diarrhea incidence from facility-based surveillance requires estimating the population at risk and accounting for case patients who do not seek care. The Enterics for Global Health (EFGH) Shigella surveillance study will characterize population denominators and healthcare-seeking behavior proportions to calculate incidence rates of Shigella diarrhea in children aged 6–35 months across 7 sites in Africa, Asia, and Latin America. Methods The Enterics for Global Health (EFGH) Shigella surveillance study will use a hybrid surveillance design, supplementing facility-based surveillance with population-based surveys to estimate population size and the proportion of children with diarrhea brought for care at EFGH health facilities. Continuous data collection over a 24 month period captures seasonality and ensures representative sampling of the population at risk during the period of facility-based enrollments. Study catchment areas are broken into randomized clusters, each sized to be feasibly enumerated by individual field teams. Conclusions The methods presented herein aim to minimize the challenges associated with hybrid surveillance, such as poor parity between survey area coverage and facility coverage, population fluctuations, seasonal variability, and adjustments to care-seeking behavior. [ABSTRACT FROM AUTHOR]

Background Mucormycosis is a potentially lethal mycosis. We reviewed peer-reviewed publications on mucormycosis to assess therapeutic outcomes. Methods A systematic literature search using the Ovid MEDLINE and EMBASE databases identified manuscripts describing human mucormycosis diagnosed according to European Organization for Research and Treatment of Cancer and the Mycoses Study Group criteria with therapeutic outcomes published from 2000 to 2022. Results In 126 articles, 10 335 patients were described, most from Asia (n = 6632, 66%). Diabetes was the most frequent underlying disease (n = 6188, 60%); 222 (2.1%) patients had no underlying diseases. The dominant clinical form was rhino-orbitocerebral (n = 7159, 69.3%), followed by pulmonary (n = 1062, 10.3%). Of 5364 patients with outcome data, amphotericin B monotherapy (n = 3749, mortality 31.5%) was most frequent, followed by amphotericin B + azole (n = 843, mortality 6.6%; P <.0001), amphotericin B followed by azole (n = 357, mortality 13.7%; P <.0001), posaconazole only (n = 250, mortality 17.2%; P <.0001), and isavuconazole only (n = 65, mortality 24.6%; P =.24). Duration and dose of antifungals varied widely. Documented outcomes from surgical resections in 149 patients found that 47 of 125 died (37.6%), compared with 16 of 24 (66.7%) patients who did not undergo surgery (P =.008). Conclusions Mucormycosis is more frequently reported in Asia than in Europe and is often linked to diabetes. Antifungal therapy, usually with surgery, is frequently effective for mucormycosis. [ABSTRACT FROM AUTHOR]

An introduction is presented in which the editor discusses various topics within the issue, including the older adults' pathway to retirement in South Korea, the nutritional deficiencies at older ages, and the relationship between urbanicity and dementia in China.

HY-2A is China's first satellite altimeter mission, launched in Aug. 2011. Its geodetic mission (GM) started from 2016 March 30 till present, collecting sea surface heights for about five 168-d cycles. To test how the HY-2A altimeter performs in marine gravity derivation, we use the least-squares collocation method to determine marine gravity anomalies on 1′ × 1′ grids around the South China Sea (covering 0°–30°N, 105°E–125°E) from the HY-2A/GM-measured geoid gradients. We assess the qualities of the HY-2A/GM-derived gravity over different depths and areas using the bias and tilt-adjusted ship-borne gravity anomalies from the U.S. National Centers for Environmental Information (NCEI) and the Second Institute of Oceanography, Ministry of Natural Resources (MNR) of P. R. China. The RMS difference between the HY-2A/GM-derived and the NCEI ship-borne gravity is 5.91 mGal, and is 5.33 mGal when replacing the HY-2A value from the Scripps Institution of Oceanography (SIO) V23.1 value. The RMS difference between the HY-2A/GM-derived and the MNR ship-borne gravity is 2.90 mGal, and is 2.76 mGal when replacing the HY-2A value from the SIO V23.1 value. The RMS difference between the HY-2A and SIO V23.1 value is 3.57 mGal in open sea areas at least 20 km far away from the coast. In general, the difference between the HY-2A/GM-derived gravity and ship-borne gravity decreases with decreasing gravity field roughness and increasing depth. HY-2A results in the lowest gravity accuracy in areas with islands or reefs. Our assessment result suggests that HY-2A can compete with other Ku-band altimeter missions in marine gravity derivation. [ABSTRACT FROM AUTHOR]

Background: The disease burden of pancreatic cancer in East Asia is at a high level, but the epidemiological characteristics of pancreatic cancer in the region have not been systematically studied. Method: Joinpoint analysis was used to identify average annual percentage change (AAPC) and annual percentage change (APC) in mortality. Age-period-cohort models were used to analyze age-period cohort effects across countries. Bayesian age-period-cohort (BAPC) analysis was used to project the burden of disease for 2020-2030. Results: Pancreatic cancer mortality in males in Japan (2012-2019, APC = −0.97) and Korea (2012-2019, APC = −0.91) has shown a decreasing trend since 2012 (P <.05). However, China (2016-2019, APC = 3.21), Mongolia (2015-2.019, APC = 2.37), and North Korea (2012-2019, APC = 0.47) showed a significant increase in pancreatic cancer in both genders (P <.05). Risk factors for pancreatic cancer in East Asia remained largely stable between 2010 and 2019. Mortality of pancreatic cancer due to smoking began to decline in areas with high socio-demographic index (SDI), and mortality of pancreatic cancer due to high body mass index and high fasting plasma glucose increased with SDI. The age-standardized mortality for pancreatic cancer in Chinese males is expected to exceed that of Japan and South Korea by 2030, but the disease burden of pancreatic cancer in Japan and South Korea remains at extremely high levels. Conclusion: Economically developed countries are beginning to show a decreasing trend in the burden of pancreatic cancer disease, and developing countries are experiencing a rapid increase in the age-standardized death rate (ASDR) of pancreatic cancer. Focusing on the disease burden of pancreatic cancer in East Asia, this study analyzed average annual percentage change and annual percentage change in mortality, age-period cohort effects across countries, and the projected burden of disease for 2020-2030. Results are presented here. [ABSTRACT FROM AUTHOR]

Typhoid places a substantial economic burden on low- and middle-income countries. We performed a literature review and critical overview of typhoid-related economic issues to inform vaccine introduction. We searched 4 literature databases, covering 2000–2017, to identify typhoid-related cost-of-illness (COI) studies, cost-of-delivery studies, cost-effectiveness analyses (CEAs), and demand forecast studies. Manual bibliographic searches of reviews revealed studies in the gray literature. Planned studies were identified in conference proceedings and through partner organization outreach. We identified 29 published, unpublished, and planned studies. Published COI studies revealed a substantial burden in Asia, with hospitalization costs alone ranging from $159 to $636 (in 2016 US$) in India, but there was less evidence for the burden in Africa. Cost-of-delivery studies are largely unpublished, but 1 study found that $671 000 in government investments would avert $60 000 in public treatment costs. CEA evidence was limited, but generally found targeted vaccination programs to be cost-effective. This review revealed insufficient economic evidence for vaccine introduction. Countries considering vaccine introduction should have access to relevant economic evidence to aid in decision-making and planning. Planned studies will fill many of the existing gaps in the literature. [ABSTRACT FROM AUTHOR]

SUMMARY: On the 9th of January 2020, an Mw 6.4 strike-slip earthquake took place north of the Asian margin of the Bering Sea. The earthquake occurred within the known reverse-right-lateral active fault zone, called Khatyrka–Vyvenka, which transverses the Koryak Highland from SE to NW and is thought to be a surface manifestation of the Asian portion of either the Bering plate boundary or the northern edge of the Alaskan stream. No other strong earthquake has ever been recorded in this remote uninhabited area and the few existing seismic stations provide poor quality earthquake locations. We adopt SAR interferometry (InSAR) technique to define an improved location of the Koryak 2020 earthquake and constrain the seismic source. The analysis of the 2020 event revealed a previously unknown active fault of left-lateral kinematics that is possibly hidden and strikes NW transversely to the Khatyrka–Vyvenka fault zone. Although several mechanisms could account for left-lateral kinematics of this fault, we propose that the structure is part of a more extended NW fault structure, that formed in pre-neotectonic times and has played a role of a pre-existing rheological discontinuity. This revived NW structure together with a similar structure located easterly, so far aseismic, make the plate/stream boundary segmented, step-like in plan view. The step-like boundary geometry may be the result of internal transform deformation of a rigid plate, but it is better explained by deflections of the Alaskan stream edge at local crustal asperities, which are pre-Cenozoic terrains. [ABSTRACT FROM AUTHOR]

A recent molecular phylogeny of the genus Crematogaster reclassified some members of the former subgenera Paracrema and Physocrema into the C. inflata -group, now comprised of five species: C. ampullaris , C. inflata , C. modiglianii , C. onusta and C. subcircularis. Here, a molecular analysis of the Crematogaster inflata -group and eight other species of the former subgenus Physocrema (C. aurita , C. difformis , C. mucronata , C. physothorax , C. sewardi , C. tanakai , C. vacca and C. yamanei) is conducted using a total of c. 4 kb of sequence data from six nuclear protein-coding genes and two mitochondrial genes. Monophyly of the C. inflata -group is strongly supported. A revised morphological delineation of the subgroups is proposed, supported by the molecular phylogeny: three morphologically distinct subgroups, the C. difformis -subgroup, the C. vacca -subgroup and the C. inflata -subgroup. Molecular dating and biogeographical analyses indicate that the C. inflata -group originated in the Sundaic region around the Middle Miocene 12 Mya and diversified from the Late Miocene to Pliocene. Ancestral state reconstructions indicate that the C. inflata -group diversified from an ancestor with a swollen propodeum and circular-shaped metapleural gland opening. Biogeographical reconstruction indicates that dispersal to peripheral areas and allopatry due to sea-level changes shaped the evolutionary history of the C. inflata -group. [ABSTRACT FROM AUTHOR]

Complementary and alternative medicine (CAM) has been one of the popular strategies for health promotion. Traditional East Asian medicine (TEAM) is one of the most popular CAM practices in the world and there are suggestions that its holistic utilization is important for users to gain its effects for health promotion. In this context, this study investigates the extent to which TEAM users in East Asian countries utilize various modalities of TEAM holistically. It provides a model that explains cross-national differences in the extent of the holistic use of TEAM between China, Japan, Korea and Taiwan. Using the 2010 East Asian Social Survey, regression models specify the relationship between the holistic use of TEAM and the geographical location (country). The presence of TEAM doctors who hold the comprehensive and exclusive practice rights over TEAM is found to be conducive to the holistic utilization of various TEAM modalities. Thus, Taiwanese and Koreans use TEAM more holistically than Chinese and even more so than Japanese. The result suggests that the manner in which TEAM is institutionalized affect the extent to which TEAM users utilize various TEAM modalities together and potentially the health promotion effects of TEAM. [ABSTRACT FROM AUTHOR]

Atopic dermatitis (AD) is a global condition that has a rising prevalence in developing countries such as those within South-east Asia and Latin America. Recent research represents the condition as a heterogeneous disease of distinct endotypes among different ethnic groups. Variation between ethnic groups in physiological measures such as transepidermal water loss, ceramide/+, skin sensitivity, alongside pathological barrier and immune system dysfunction processes, may ultimately lead to the distinct phenotypes seen clinically. AD in patients of White ethnicities is typified by filaggrin dysfunction, more T helper (Th)1 and less Th17 involvement, with less epidermal thickness compared with patients of Black or Asian ethnicities. AD in patients of Black ethnic groups is Th2/Th22-skewed, with robust IgE expression, and less Th1 and Th17 involvement than patients of Asian or White ethnicities. AD across South Asian and East Asian populations is characterized by Th17/Th22 upregulation. Differences also exist in how AD psychosocially has an impact on individuals of different ethnic groups. [ABSTRACT FROM AUTHOR]

Cordyceps militaris is a medicinal mushroom in Asia in the 21st century, which cordycepin is a significant bioactive compound. This study, investigated the effect of culture conditions and vegetable seed extract powder as a supplementary source of animal-free nitrogen on the production of cordycepin by C. militaris in liquid surface culture. The highest cordycepin production was observed under soybean extract powder (SBEP) conditions, and 80 g L−1 of SBEP supplementation increased cordycepin production to 2.52 g L−1, which was greater than the control (peptone). Quantitative polymerase chain reaction was used to examine the transcription levels, and the results showed that supplementing with SBEP 80 g L−1 significantly increased the expression of genes associated with the carbon metabolic pathway, amino acid metabolism, and two key genes involved in the cordycepin biosynthesis (cns1 and NT5E) compared to peptone-supplemented culture. Under optimal culture conditions, the model predicted a maximum response of cordycepin production of 2.64 g L−1 at a working volume of 147.5 ml, an inoculum size of 8.8% v/v, and a cultivation time of 40.0 days. This optimized culture condition could be used to increase cordycepin production in large-scale bioreactors. Additional research can be conducted to assess the economic viability of this process. [ABSTRACT FROM AUTHOR]

The microsporidian, Nosema maddoxi Becnel, Solter, Hajek, Huang, Sanscrainte & Estep, infects brown marmorated stink bug, Halyomorpha halys (Stål) (Hemiptera: Pentatomidae), populations in North America and Asia and causes decreased fitness in infected insects. This host overwinters as adults, often in aggregations in sheltered locations, and variable levels of mortality occur over the winter. We investigated pathogen prevalence in H. halys adults before, during, and after overwintering. Population level studies resulted in detection of N. maddoxi in H. halys in 6 new US states, but no difference in levels of infection by N. maddoxi in autumn versus the following spring. Halyomorpha halys that self-aggregated for overwintering in shelters deployed in the field were maintained under simulated winter conditions (4°C) for 5 months during the 2021–2022 winter and early spring, resulting in 34.6 ± 4.8% mortality. Over the 2020–2021 and 2021–2022 winters, 13.4 ± 3.5% of surviving H. halys in shelters were infected with N. maddoxi , while N. maddoxi infections were found in 33.4 ± 10.8% of moribund and dead H. halys that accumulated in shelters. A second pathogen, Colletotrichum fioriniae Marcelino & Gouli, not previously reported from H. halys , was found among 46.7 ± 7.8% of the H. halys that died while overwintering, but levels of infection decreased after overwintering. These 2 pathogens occurred as co-infections in 11.1 ± 5.9% of the fungal-infected insects that died while overwintering. Increasing levels of N. maddoxi infection caused epizootics among H. halys reared in greenhouse cages after overwintering. [ABSTRACT FROM AUTHOR]

A sequence of three strong (M W7.2, 6.4, 6.6) earthquakes struck the Pamir of Central Asia in 2015–2017. With a local seismic network, we recorded the succession of the foreshock, main shock and aftershock sequences at local distances with good azimuthal coverage. We located 11 784 seismic events and determined 33 earthquake moment tensors. The seismicity delineates the tectonic structures of the Pamir in unprecedented detail, that is the thrusts that absorb shortening along the Pamir's thrust front, and the strike-slip and normal faults that dissect the Pamir Plateau into a westward extruding block and a northward advancing block. Ruptures on the kinematically dissimilar faults were activated subsequently from the initial M W 7.2 Sarez event at times and distances that follow a diffusion equation. All main shock areas but the initial one exhibited foreshock activity, which was not modulated by the occurrence of the earlier earthquakes. Modelling of the static Coulomb stress changes indicates that aftershock triggering occurred over distances of ≤90 km on favourably oriented faults. The third event in the sequence, the M W 6.6 Muji earthquake, ruptured despite its repeated stabilization through stress transfer in the order of –10 kPa. To explain the accumulation of M W > 6 earthquakes, we reason that the initial main shock may have increased nearby fault permeability, and facilitated fluid migration into the mature fault zones, eventually triggering the later large earthquakes. [ABSTRACT FROM AUTHOR]

In the context of Asia, understanding migration governance needs to transcend statism to encompass the 'middle space' of migration. Unlike migration linked to settlement in liberal democratic states of the West, a large part of low-skilled migration in Asia - predominantly circular, feminized, and contractual--is brokered by private recruitment agencies. In adopting migration brokers as a methodological starting point, we make the case for bringing the migration industry into the fold of global migration governance analysis. Based on interviews with employment agencies deploying Indonesian domestic workers to Singapore from 2015 to 2016, we argue that migrant-destination states in Asia devolve responsibility for workers to the migration industry to order migration flows and circumvent formal cooperation with origin countries. Comprehending migration governance in Asia requires grappling with the co-constitutive governance of the state and migration industry and its interdependent dynamics, which we illuminate through the theory of strategic action fields. [ABSTRACT FROM AUTHOR]

An introduction to the journal is presented that discusses articles published on this issue including the one by Wallace Chan on the Meaning in Life Questionnaire, another by Heather Boetto on promoting an eco-social approach in social work practice, and the one on ecological justice principles.

India has used civilizational discourses as part of its foreign policy to articulate its rise and rightful place in the world order. This article primarily examines India's civilizational arguments in south Asia. India's civilizational arguments in the region demand scrutiny as the neighbourhood is a theatre of contestation between territorial India and the claims of its civilizational space. Analysing historical accounts on Indian civilization, official documents and domestic narratives in India about south Asia, the article makes three points. First, India's civilizational articulation oscillates between two paradigmatic and contrasting representations of Nehruvianism and Hindutva variants. Second, it is argued that despite the ascendancy of Hindutva 's civilizational symbolism since 2014, India's south Asia policy shows no paradigmatic change. Finally, it points to how the Hindutva project may be detrimental to India's self-image and dealings in south Asia. The article argues that while there is no official corroboration of Hindutva 's claims in India's south Asia policy, the increasing salience of the domestic discussions around Akhand Bharat (undivided India) invites complications for India in its neighbourhood. India's Hindutva -driven civilizational claims raise anxieties of an Indian cultural hegemony in an asymmetric region splintered across territorial and nationalistic lines. [ABSTRACT FROM AUTHOR]

The performance of supervised deep learning-based denoising methods relies on massive amounts of high-quality training data set with labels. However, data labelling is a time-consuming and tedious process, and the lack of labelled data set has become a major bottleneck affecting the development of supervised deep learning-based denoising methods. In recent years, denoising methods that only use unlabelled noisy data set for training have received more and more attention. Although these methods get rid of the dependence on labels, they usually have some specific requirements on the training data set. For example, the paired training data are required to be multiple noisy observations for each scene or obey a specific noise distribution, etc., which are often very challenging to meet in practical applications. In this study, we propose an improved self-supervised denoising framework based on Noise2Noise that only uses noisy seismic data set for training, and we name it sample2sample. The proposed denoising framework does not require multiple repeated acquisitions of seismic data to obtain multiple independent noisy observations for each scene used for training, and has no specific requirement for the noise distribution prior. Specifically, we introduce a random sampler to generate paired subsamples from some individual noisy seismic data for training. The corresponding elements in the two paired subsamples are adjacent in the original seismic data and approximately meet the training premise of Noise2Noise, that is the paired training data have the same signal. In addition, considering that there are some subtle differences in the signals of the paired subsamples generated by sampling, we also introduce a regularization loss to compensate for this. We conducted a qualitative and quantitative analysis of the denoising performance of the proposed method through further experiments, including synthetic data experiments and field data experiments. [ABSTRACT FROM AUTHOR]

The hydraulic traits of a plant species may reflect its climate adaptations. Southwest China is considered as a biodiversity hotpot of the genus Quercus (oak). However, the hydraulic adaptations of Asian oaks to their climate niches remain unclear. Ten common garden-grown oak species with distinct natural distributions in eastern Asia were used to determine their stem xylem embolism resistance (water potential at 50% loss of hydraulic conductivity, P 50), stem hydraulic efficiency (vessel anatomy and sapwood specific hydraulic conductivity (K s)) and leaf anatomical traits. We also compiled four key functional traits: wood density, hydraulic-weighted vessel diameter, K s and P 50 data for 31 oak species from previous literature. We analyzed the relationship between hydraulic traits and climatic factors over the native ranges of 41 oak species. Our results revealed that the 10 Asian oak species, which are mainly distributed in humid subtropical habitats, possessed a stem xylem with low embolism resistance and moderate hydraulic efficiency. The deciduous and evergreen species of the 10 Asian oaks differed in the stem and leaf traits related to hydraulic efficiency. K s differed significantly between the two phenological groups (deciduous and evergreens) in the 41-oak dataset. No significant difference in P 50 between the two groups was found for the 10 Asian oaks or the 41-oak dataset. The oak species that can distribute in arid habitats possessed a stem xylem with high embolism resistance. K s negatively related to the humidity of the native range of the 10 Asian oaks, but showed no trend when assessing the entire global oak dataset. Our study suggests that stem hydraulic conductivity and embolism resistance in Quercus species are shaped by their climate niche. Our findings assist predictions of oak drought resistance with future climate changes for oak forest management. [ABSTRACT FROM AUTHOR]

Vigna reflexo-pilosa (créole bean) is a wild legume belonging to the subgenus Ceratoropis and is widely distributed in Asia. Créole bean is the only tetraploid species in the genus Vigna , and it has been shown to derive from the hybridization of Vigna hirtella and Vigna trinervia. In this study, we combined the long-read PacBio technology with the chromatin contact mapping (Hi-C) technique to obtain a chromosome-level assembly of V. reflexo-pilosa. The final assembly contained 998,724,903 bases with an N50 length of 42,545,650 bases. Our gene prediction recovered 99.4% of the highly conserved orthologs based on the BUSCO analysis. To investigate homoeolog expression bias and expression level dominance in the tetraploid, we also sequenced and assembled the genomes of its progenitors. Overall, the majority of the homoeolog pairs (72.9%) displayed no expression bias, and among those that exhibited biased expression, 16.3% showed unbalanced homoeolog expression bias toward the V. trinervia subgenome. Moreover, 41.2% and 36.2% of the expressed gene pairs exhibited transgressive expression and expression level dominance, respectively. Interestingly, the genome-wide expression level dominance in the tetraploid was biased toward the V. trinervia subgenome. The analysis of methylation patterns also revealed that the average methylation levels in coding regions were higher in the V. hirtella subgenome than those in the V. trinervia subgenome. The genomic/transcriptomic resources for these three species are useful not only for the development of elite cultivars in Vigna breeding programs but also to researchers studying comparative genomics and investigating genomic/epigenomic changes following polyploid events. [ABSTRACT FROM AUTHOR]

The M w 7.9 2015 April 25 Gorkha earthquake is the latest of a millenary-long series of large devastating Himalayan earthquakes. It is also the first time a large Himalayan earthquake and its aftershocks were recorded by a local network of seismic stations. In the 5 yr following the main shock, more than 31 000 aftershocks were located by this permanent network within the ruptured area, including 14 362 events with M L greater than 2.5, 7 events with M L > 6, including one large aftershock with M w 7.2 on 2015 May 12. In 2020, 5 yr after the main shock, the seismicity rate along the ruptured fault segments was still about 5 times higher than the background seismicity before the Gorkha earthquake. Several bursts of earthquakes, sometimes organized in clusters, have been observed from a few days to several years after the main shock. Some of these clusters were located at the same place as the clusters that happened during the decades of interseismic stress build-up that preceded the large earthquake. They also happened in the vicinity of the high frequency seismic bursts that occurred during the main shock. These heterogeneities contribute to a persistent segmentation of the seismicity along strike, possibly controlled by geological structural complexities of the Main Himalayan Thrust fault. We suggest that these pre-2015 clusters revealed the seismo-geological segmentation that influences both the coseismic rupture and the post-seismic relaxation. [ABSTRACT FROM AUTHOR]

Bradysia odoriphaga (Diptera: Sciaridae) is a major insect pest of seven plant families including 30 commercial crops in Asia. The long-term use of chemical pesticides leads to problems such as insect resistance, environmental issues, and food contamination. Against this background, a novel pest control method should be developed. In insects, odorant-binding proteins (OBPs) transport odor molecules, including pheromones and plant volatiles, to olfactory receptors. Here, we expressed and characterized the recombinant B. odoriphaga OBP BodoOBP10, observing that it could bind the sulfur-containing compounds diallyl disulfide and methyl allyl disulfide with Ki values of 8.01 μM and 7.00 μM, respectively. Homology modeling showed that the BodoOBP10 3D structure was similar to that of a typical OBP. Both diallyl disulfide and methyl allyl disulfide bound to the same site on BodoOBP10, mediated by interactions with six hydrophobic residues Met70, Ile75, Thr89, Met90, Leu93, and Leu94, and one aromatic residue, Phe143. Furthermore, silencing BodoOBP10 expression via RNAi significantly reduced the electroantennogram (EAG) response to diallyl disulfide and methyl allyl disulfide. These findings suggest that BodoOBP10 should be involved in the recognition and localization of host plants. [ABSTRACT FROM AUTHOR]