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Background: In previous decades, large-scale research has been carried out on bacterial meningitis. In every field, citation analysis is the most significant contribution. The study's objective was to identify and analyze the 100 articles on bacterial meningitis that received the most citations between 2000 and 2023, highlighting the most significant developments in the field. Objective: The objective of this study was to find out what makes a highly influential article by identifying and analyzing the characteristics of the 100 articles in the field of bacterial meningitis that receive the most citations. The goal of this study was to find and examine the 100 articles on bacterial meningitis that received the most citations. Methodology: We identified the top 100 most-cited papers in the field of bacterial meningitis from 55 journals using the Dimensions AI database. The results of each author's analysis of 100 articles were then compared. We gathered fundamental data such as the journal's title, country of publication, and study type. Descriptive counts or percentages were used to compare the various categories. Results: Between the year 2000 and the year 2023, articles were published. The total number of citations ranged from 115 to 1176, with 42 papers receiving more than 200 citations. In 2008, 14 articles were published, followed by 10 in 2000 and 2007. One thousand one hundred and seventy-six times were given to the most-cited paper, whereas 115 times were given to the least-cited article. "Clinical Features and Prognostic Factors in Adults with Bacterial Meningitis," by Diederik van de Beek, et al. (2004) was the article that received the most citations. 1176 people have cited this article. van de Beek Diederik of the Academic Medical Center in The Netherlands is the author who has written the most articles, was mentioned in 14 of the top 100 articles. Papers were primarily published in Pediatrics (n = 9) publication with 1861 citations. The Netherlands came in second with 18 publications, followed by the United States (n = 46). Conclusion: Our study uses bibliometrics and visualization analysis of the most important articles in this field to show the current state of research in the area of bacterial meningitis, provide a history of research trends, and offer a perspective for future bacterial predicts the growth of meningitis. [ABSTRACT FROM AUTHOR]

Highly cited papers showcase high-quality research and encompass significant themes in the field. This study examined a total of 435 highly cited papers based on Essential Citation Indicators in the Web of Science (WoS) category of sport sciences with a bibliometric method. In particular, the bibliometric indicators of the highly cited papers including publication venues, authors, countries, institutions, and the top cited publications were presented and analyzed in detail. An Abstract corpus was constructed to help identify the most frequently explored topics. VOSviewer was employed to visualize the co-occurrence networks of keywords. The study revealed the trending information of important contributors at the levels of journals, authors, countries, and institutes. The top cited publications can be grouped into three categories: guidelines, recommendations based on systematic reviews, and evaluations. The most frequently explored topics based on the Abstract corpus and the most frequently used keywords from VOSviewer mapping overlap to a great extent. Specifically, topics such as meta-analysis, systematic review, sport-related concussion, sedentary behavior, football, rehabilitation, and osteoarthritis are among the most frequently mentioned. The results provide the most updated publication characteristics and hot topics of highly cited papers in sport sciences and offer insights for academic researchers in future research. [ABSTRACT FROM AUTHOR]

The effects of filter paper strip (FPS) storage time and temperature on antibody detection are poorly understood despite widespread use in wildlife research. We collected sera and FPSs from 23 wild turkeys (Meleagris gallopavo) and 20 northern bobwhites (Colinus virginianus) experimentally infected with West Nile virus (WNV) to compare FPS storage methods with WNV plaque reduction neutralization test (PRNT) sensitivity. FPS storage methods included: immediate elution after drying, and storage at −20°C for 3 mo, −20°C for 6 mo, room temperature (RT) for 3 mo, and RT for 6 mo prior to elution. FPS eluates and sera were co-titrated to determine endpoint antibody titers, which were compared between FPS sera eluted immediately and sera, and among FPS eluates that underwent different storage conditions. Antibody titers were ~4-fold less in FPS sera eluted immediately versus sera, and dropped more frequently below PRNT detection threshold in northern bobwhites, which had ~10-fold lower serum antibody titers than wild turkeys. Antibody titers were lower in FPS samples stored at RT and for 6 mo. WNV serologic surveys may result in falsely low seroprevalence estimates if FPSs are stored at RT for ≥ 3 mo before elution. [ABSTRACT FROM AUTHOR]

In this brief communication, we highlight several critical inaccuracies in the paper entitled "A novel methodology for a time-delayed controller to prevent nonlinear system oscillations," identified by the DOI: 10.1177/14613484231195276. The core of the non-perturbative approach discussed in this paper is the introduction of a trial solution with an indeterminate nonlinear frequency. We elucidate the technical missteps and provide necessary corrections. The scrutinized article presents ample opportunities for enhancement, and we propose several amendments. Additionally, we reveal that the numerical outcomes showcased in the mentioned paper expose deficiencies in the proposed approximate solution. With the amendments implemented herein, a more precise numerical solution is achieved. [ABSTRACT FROM AUTHOR]

Rabbit hemorrhagic disease virus 2 (RHDV2), a virulent and contagious viral pathogen that affects wild and domestic lagomorph populations, was identified in Wyoming, USA in December 2020. A surveillance program was developed involving full-carcass submission and liver analysis, although carcass quality as a result of predation and decomposition impeded analysis. To increase the number of submissions and provide flexibility to field staff, we evaluated 2 sample types: 77 dried blood on filter paper samples, 66 ear punch samples. At initial sampling, test specificity and sensitivity of the RT-rtPCR utilizing dried blood on filter paper and ear punch samples were both 100% compared to liver. Filter paper results were consistent over time; sensitivity stayed >96% through weeks 2, 4, and 6, with a maximum mean difference of 6.0 Ct from baseline liver Ct values (95% CI: 5.0–7.3) at 6 wk. Test sensitivity of the ear punch sample at 1, 3, 5, and 7 wk post-sampling remained at 100%, with a maximum mean difference of 5.6 Ct from baseline liver Ct values (95% CI: 4.3–6.9) at 5 wk. Filter paper and ear punch samples were suitable alternatives to liver for RHDV2 surveillance in wild lagomorph populations. Alternative sampling options provide more flexibility to surveillance programs, increase testable submissions, and decrease exposure of field personnel to zoonotic disease agents. [ABSTRACT FROM AUTHOR]

An editorial is presented that discusses what constitutes a contribution at the "Journal of Management" ("JOM"). The authors note that the key requirement for impact at JOM is that a paper "substantively moves the field of management forward." The theoretical insights path, the phenomenon-driven path, the research methodology path, and the review paper path are all explored.

Compared to the abundant generic research on technologies and education, few studies focus on the scope of whether the technologies used meet the expectations set forth in international reports and to what extent technology contributes to transforming educational practice. Our objective was to identify and analyze the characteristics of educational practices that are being developed in higher education and to assess the value that technology brings to educational practice. We conducted a systematic review of academic papers published in scientific journals: a corpus of 1,207 articles from six journals included in indexed databases (JCR and SJR), selected using Google Scholar Metrics. According to the various records screened, the study we present is based on 49 articles, published between 2018 and 2019. We conclude that beyond their reproducible, enriching, or transformative nature, most of the articles analyzed address the improvement of students' performance, engagement, or self-perception, in which they positively value the experience of learning mediated by digital technology, although they do not have an impact on the transformative value. [ABSTRACT FROM AUTHOR]

We describe the pioneering role of the Production and Operations Management (POM) in promoting empirical research in innovation, operations, and supply chain management. We also review and discuss the most influential empirical papers published in POM based on each paper's Google Scholar citation counts. We selected the top 200 cited papers from the 2085 papers published or forthcoming in POM to identify the most influential empirical papers. We classify these 200 papers into three categories: (a) review and conceptual development, (b) analytical, and (c) empirical papers, and then compare these papers across the categories in terms of citation counts. Next we analyze the 75 empirical papers from the top 200 cited papers published in POM by covered topics, data sources, and data analysis methods. Focusing the analysis on empirical papers among the top 200 cited papers can underrepresent emerging themes among the more recently published empirical papers. Therefore, we also analyze 19 more recent empirical papers from 2016 to 2021 that are not covered in the top 200 cited papers but have been impactful given the brief time since their publication. We conclude by offering our thoughts on how editors, reviewers, and authors can work together to further enhance and ensure the quality and influence of future operations management (OM) empirical science research. [ABSTRACT FROM AUTHOR]

Background: Harmful Alcohol use is frequent among opioid dependents patients undergoing agonist maintenance treatment. The objective assessment of harmful alcohol use can be done using laboratory measures of serum biomarkers. For community-based patients, there is often a requirement of an alternative method due to lack of onsite laboratory services. The aim of the study was to examine filter paper as a matrix to measure serum biomarkers of harmful alcohol use. Methods: The initial phase involved standardization of the filter-paper-based assay. Conditions were optimised for extraction and estimation of alcohol biomarkers (Aspartate Aminotransferase; AST, Alanine Aminotransferase; ALT, Gamma Glutamyl transferase; GGT and Carbohydrate Deficient Transferrin; CDT) from the filter paper. For clinical validation, serum samples were collected from community clinics. Biomarker levels obtained from both the methods were correlated using linear regression analysis. Limits of agreement between the two methods was estimated using the Intraclass Correlation Coefficient (ICC). Results: The extraction of enzymes (AST, ALT and GGT) from filter paper was carried out using the substrate buffer available with the reagent kit (Randox, UK). CDT was readily extracted from filter paper using deionised water. Serum biomarker levels measured from samples collected from community clinics correlated well with filter paper extracted levels (ICC 0.97-0.99). More than 90% of alcohol biomarker levels were recovered from the filter paper matrix using this method. Conclusion: Filter paper has the potential to be used as a matrix to objectively measure alcohol biomarkers among opioid-dependent patients from community settings lacking onsite laboratory facilities. [ABSTRACT FROM AUTHOR]

The research process of authoring a review paper constitutes a uniquely important context for interrogating tacit premises and presuppositions, especially when the review aspires to synthesize a methodologically diverse field of research. This article presents a reflexive recounting of a research experience with mixed methods team-based review paper authorship, showing how the function of a review paper may be differently conceptualized by scholars situated in methodological traditions that place their emphasis on drawing-together knowledge about the social world versus those situated in methodological traditions whose primary aim is to unpack accepted categories. The analysis thus offers insights into dimensions of methodological difference as they operate in practice, while underscoring the significance of reflexivity in the review paper context for purposes of advancing meaningfully inclusive maps of an intellectual community's self-understanding(s). [ABSTRACT FROM AUTHOR]

Tissue engineering (TE) is the multi-disciplinary approach to building 3D human tissue equivalents in the laboratory. The advancement of medical sciences and allied scientific disciplines have aspired to engineer human tissues for three decades. To date there is limited use of TE tissues/organs as replacement body parts in humans. This position paper outlines advances in engineering of specific tissues and organs with tissue-specific challenges. This paper outlines the technologies most successful for engineering tissues and key areas of advancement. [ABSTRACT FROM AUTHOR]

Facial masks are beauty products which composed of a facial mask paper and beauty solution. Silk contains the amino acid structure closest to the human skin, and has the skin-friendly, cosmetic and antibacterial functions, but the common method for making nonwoven facial mask paper is not suitable for silk. In this paper, the silkworm's spinning path is intervened manually to obtain a smart silk facial mask paper (SMC) of controllable thickness, so that the sericin on the silk fiber is well preserved. In the experiment where the SMC is compared with the nonwoven 384-cuprammonium rayon facial mask paper (CRMC) which is the most widely used in the market, it is found that the ways of forming the two facial mask paper are completely different, and therefore the morphologies under SEM are obviously different. The thickness of the SMC is 0.183 mm and the areal weight of it is 38.0 g/m2. It is very close to the CRMC (0.187 mm, 38.4 g/m2). The porosity of the SMC is 84.0%, which is slightly lower than that of the CRMC (86.3%), but its pores are well distributed. Compared with the CRMC, the smart SMC has higher dry and wet strength, lower elongation, slightly lower air permeability and liquid entrainment rate, and better antibacterial performance. [ABSTRACT FROM AUTHOR]

Cerebral autoregulation (CA) refers to the control of cerebral tissue blood flow (CBF) in response to changes in perfusion pressure. Due to the challenges of measuring intracranial pressure, CA is often described as the relationship between mean arterial pressure (MAP) and CBF. Dynamic CA (dCA) can be assessed using multiple techniques, with transfer function analysis (TFA) being the most common. A 2016 white paper by members of an international Cerebrovascular Research Network (CARNet) that is focused on CA strove to improve TFA standardization by way of introducing data acquisition, analysis, and reporting guidelines. Since then, additional evidence has allowed for the improvement and refinement of the original recommendations, as well as for the inclusion of new guidelines to reflect recent advances in the field. This second edition of the white paper contains more robust, evidence-based recommendations, which have been expanded to address current streams of inquiry, including optimizing MAP variability, acquiring CBF estimates from alternative methods, estimating alternative dCA metrics, and incorporating dCA quantification into clinical trials. Implementation of these new and revised recommendations is important to improve the reliability and reproducibility of dCA studies, and to facilitate inter-institutional collaboration and the comparison of results between studies. [ABSTRACT FROM AUTHOR]

In this paper I consider various shifts in my research and understanding stimulated by seeking how to combat social ecological crises connected to modern economies. The discussion and critical reflections are structured around five papers that were submitted to Environmental Values in an open call to address my work. A common aspect is the move away from neoclassical environmental economics, and its reductionist monetary valuation, to a more realist theory and multiple methods. This relates to my work on environmental ethics, plural values, stated preference validity and deliberative monetary valuation. Expanding beyond the narrow confines of mainstream orthodoxy has involved exploring a range of other disciplines (e.g. applied philosophy, social psychology, human geography, political science, social anthropology, history of thought and philosophy of science) and learning from this literature to rethink economics and develop social ecological economics. A broad range of subjects are covered here, including: personal responsibility, social practice, psychology of the individual, participatory processes, value (intrinsic, instrumental and relational), Nature–society relationships and interdependencies, critical realism and the conduct of unifying interdisciplinary science. I end with a series of comments concerning the failings of orthodox economics and the conduct of scientific research for social ecological transformation. [ABSTRACT FROM AUTHOR]

In recent years, the problem caused by waste disposable paper cups (WDPCs) has became a topic of great concern to scientists, and commercial companies have also begun to take an interest in developing processes for tackling the issue. In this review, the inherent problems and social barriers during the recycling of WDPCs are described. This review presents the major conclusions of previously published works focused on the utilisation of WDPCs for material and energy purposes. The commercial utilisation of WDPCs is also described. Some suggestions for better recycling of WDPCs are given in the final part of this work. [ABSTRACT FROM AUTHOR]

Air quality control has become increasingly important in many industrial areas. Glass fiber filter paper is widely used for the collection of airborne particulate matter. Since glass fiber is fragile, fiber dispersion is believed to be important for controlling filter paper properties. In this paper, the impact of fiber dispersion on filtration performance and tensile properties was studied. Two types of glass fiber filter paper prepared from six different dispersing methods were used to analyze the impact of dispersion on filtration and tensile properties. Rotational viscosity was used to characterize the fiber dispersion process. Dispersing strength and time had no significant effect on filtration properties, namely the pressure drop, penetration and figure of merit. The fiber composition should be the determining factor of filtration properties. Dispersing strength and time had little effect on the virgin tensile strength of glass fiber paper, while the tensile strength retention after folding was highly affected by dispersion. It is suggested that fiber cutting should be reduced in the fiber dispersion process for higher tensile strength retention. [ABSTRACT FROM AUTHOR]

Facial masks are beauty products which composed of a facial mask paper and beauty solution. Silk contains the amino acid structure closest to the human skin, and has the skin-friendly, cosmetic and antibacterial functions, but the common method for making nonwoven facial mask paper is not suitable for silk. In this paper, the silkworm's spinning path is intervened manually to obtain a smart silk facial mask paper (SMC) of controllable thickness, so that the sericin on the silk fiber is well preserved. In the experiment where the SMC is compared with the nonwoven 384-cuprammonium rayon facial mask paper (CRMC) which is the most widely used in the market, it is found that the ways of forming the two facial mask paper are completely different, and therefore the morphologies under SEM are obviously different. The thickness of the SMC is 0.183 mm and the areal weight of it is 38.0 g/m2. It is very close to the CRMC (0.187 mm, 38.4 g/m2). The porosity of the SMC is 84.0%, which is slightly lower than that of the CRMC (86.3%), but its pores are well distributed. Compared with the CRMC, the smart SMC has higher dry and wet strength, lower elongation, slightly lower air permeability and liquid entrainment rate, and better antibacterial performance. [ABSTRACT FROM AUTHOR]

Previous research is inconclusive regarding the effects of paper and web surveys on response burdens. We conducted an establishment survey with random assignment to paper and web modes to examine this issue. We compare how the actual and perceived response burdens differ when respondents complete a survey in the paper mode, in the web mode and when they are allowed to choose between the two modes. Our results show that in the web mode, respondents have a lower estimated time to complete the questionnaire, while we do not find differences between paper and the web on the perceived response time and perceived burden. Even though the response burden in the web mode is lower, our study finds no evidence of an increased response burden when moving an establishment survey from paper to the web. [ABSTRACT FROM AUTHOR]

Background: Inaccessible services and poor communication are barriers to successful transitions between adolescent and adult mental health services, for which digital communications (DC) offer a possible solution. Aims: To investigate the role of DC, including smartphone apps, email and text, given the known barriers and facilitators of mental health service transitions reported in the literature. Methods: Use of Neale's (2016) iterative categorisation technique to undertake a secondary analysis of qualitative data collected for the Long-term conditions Young people Networked Communication (LYNC) study. Results: DC were used successfully by young people and staff in ways that ameliorated known barriers to service transitions. They engendered responsibility in young people, promoted service access and contributed to client safety, particularly in times of crisis. DC risks included over-familiarity between young people and staff, and the possibility that messages could go unread. Conclusions: DC have the potential to facilitate trust and familiarity during and after transition to adult mental health services. They can strengthen young people's perceptions of adult services as supportive, empowering and available. DC can be used for frequent 'check-ins' and remote digital support for social and personal problems. They provide an additional safety net for at-risk individuals, but require careful boundary setting. [ABSTRACT FROM AUTHOR]

The article discusses the issue of common-method bias (CMB) in organizational behavior (OB) and management-related journals. The author argues that CMB is overused by reviewers and editors as a reason to reject papers, and presents empirical, theoretical, and practical evidence to support this argument. The author suggests that concerns about CMB are often unnecessary and that single-source and single-wave data can still provide valuable insights. The article also addresses the practical implications of requiring multi-phase studies to avoid CMB, such as the potential for fake data and difficulties in surveying certain populations. Overall, the author contends that CMB should not be treated as a fatal flaw in papers. [Extracted from the article]

We describe the process used to identify the ten most influential papers published in the Production and Operations Management (POM) journal in its first thirty years. We also briefly discuss and highlight the selected papers. [ABSTRACT FROM AUTHOR]

This paper analyses how a state produces new internal borders. It selected 1668 newspaper articles on the COVID-19 internal bordering case in Slovakia to answer this question. These articles were then analysed using the thematic trajectory analysis (TTA) through the conceptual prism of structurationism. The results suggest states apply methods during the production of internal borders similar to those used during the (re-)production of an international border. In particular, it shows the application of a military-testing nexus and economic tools to ensure compliance with the new border. Results also revealed that such a border is heavily dependent on popular support for the government and open to re-negotiations by relevant societal groups. From the border production perspective, this study offers a preliminary step into the area of internal borders imposed on a generally homogenous population, especially regarding the borders produced under COVID-19 conditions. [ABSTRACT FROM AUTHOR]

I trace the bibliometric evolution of "New Public Management Is Dead" by Dunleavy et al. to investigate how the seminal paper influenced the administrative reform debate. They suggested Digital-Era Governance as the main post-NPM idea. My bibliometric analysis discovers public value, administrative reform trajectories, and digital government as influential themes. Unlike Dunleavy et al., the literature found the managerial reform wave is not linear, reform ideas are supplementary, and NPM remains a major toolkit. Future research should focus on reintegration and need-based holism, linking digital government to administrative reform, and the negative impact of digital government on democracy. [ABSTRACT FROM AUTHOR]

In this study, carbon papers and aerogels were prepared from chitosan and graphene layers with aldehydic edge functional groups (G-CHO) able to form chemical bonds with chitosan and thus to form a crosslinked network. A high surface area graphite was edge functionalized with hydroxyl groups (G-OH) through the reaction with KOH. G-CHO, with 4.5 mmol/g of functional group, was prepared from G-OH by means of the Reimer-Tieman reaction. Characterization of the graphitic materials was performed with elemental analysis, titration, X-ray analysis, Raman spectroscopy and by estimating their Hansen solubility parameters. CS and G-CHO were mixed with mortar and pestle and carbon papers and aerogels were obtained from a stable acidic water suspension through casting and liophilization, respectively. Free standing and foldable carbon papers and monolithic aerogels based on a continuous covalent network between G-CHO and CS were prepared. G-CHO, which had about 22 stacked layers, was extensively exfoliated in the carbon paper, as confirmed by the absence of the 002 reflection of the graphitic crystallites in the XRD pattern. Carbon paper was found to be resistant to solvents and to be stable for pH ⩾ 7. Composites revealed electrical conductivity. The covalent network between the graphene layers and CS, suggested by the IR findings, accounts for these results. This work demonstrates the effectiveness of a continuous covalent network between chitosan and graphene layers edge functionalized with tailor made functional groups for the preparation of carbon papers and aerogels and paves the way for the scale up of such a type of composites. [ABSTRACT FROM AUTHOR]

Paper-based visual analogue scale (VAS) items were developed 100 years ago. Although they gained great popularity in clinical and medical research for assessing pain, they have been scarcely applied in other areas of psychological research for several decades. However, since the beginning of digitization, VAS have attracted growing interest among researchers for carrying out computerized and paper-based data assessments. In the present study, we investigated the research question "Which different design characteristics of paper-based VAS items are preferred by women and men?" Based on a sample of 115 participants (68 female), our results revealed that the respondents preferred a paper-based VAS item with a horizontal, 8-cm long, 3 DTP ("desktop publishing point") wide, black line, with flat line endpoints, and the ascending numerical anchors "0" and "10", both for women and men. Although we did not identify any gender difference in these characteristics, our findings uncovered clear preferences on how to design paper-based VAS items. [ABSTRACT FROM AUTHOR]

Given the importance of theorizing about an entrepreneurial phenomenon, we seek to highlight the common challenges of entrepreneurship papers' theorizing and offer suggestions for how we (as a community of scholars) can address these challenges to develop more robust and impactful entrepreneurship papers to advance the entrepreneurship field. Specifically, we identify the following major reviewer comments of entrepreneurship papers regarding their scope, common features (i.e., contextualization, boundary conditions, and time considerations), and "point of view". Elaborating on these common comments of entrepreneurship theory papers, we offer guidance on incorporating these insights when writing or reviewing entrepreneurship papers. [ABSTRACT FROM AUTHOR]

Objective The purpose of the present research is to establish measurement equivalence and test differences in reliability between computerized and pencil-and-paper-based tests of spatial cognition. Background Researchers have increasingly adopted computerized test formats, but few attempt to establish equivalence for computer-based and paper-based tests. The mixed results in the literature on the test mode effect, which occurs when performance differs as a function of test medium, highlight the need to test for, instead of assume, measurement equivalence. One domain that has been increasingly computerized and is thus in need of tests of measurement equivalence across test mode is spatial cognition. Method In the present study, 244 undergraduate students completed two measures of spatial ability (i.e., spatial visualization and cross-sectioning) in either computer- or paper-and-pencil-based format. Results Measurement equivalence was not supported across computer-based and paper-based formats for either spatial test. The results also indicated that test administration type affected the types of errors made on the spatial visualization task, which further highlights the conceptual differences between test mediums. Paper-based tests also demonstrated increased reliability when compared with computerized versions of the tests. Conclusion The results of the measurement equivalence tests caution against treating computer- and paper-based versions of spatial measures as equivalent. We encourage subsequent work to demonstrate test mode equivalence prior to the utilization of spatial measures because current evidence suggests they may not reliably capture the same construct. Application The assessment of test type differences may influence the medium in which spatial cognition tests are administered. [ABSTRACT FROM AUTHOR]

The folded paper-size illusion is as easy to demonstrate as it is powerful in generating insights into perceptual processing: First take two A4 sheets of paper, one original sized, another halved by folding, then compare them in terms of area size by centering the halved sheet on the center of the original one! We perceive the larger sheet as far less than double (i.e., 100%) the size of the small one, typically only being about two thirds larger--this illusion is preserved by rotating the inner sheet and even by aligning it to one or two sides, but is dissolved by aligning both sheets to three sides, here documented by 88 participants' data. A potential explanation might be the general incapability of accurately comparing more than one geometrical dimension at once--in everyday life, we solve this perceptual-cognitive bottleneck by reducing the complexity of such a task via aligning parts with same lengths. [ABSTRACT FROM AUTHOR]

Background: While substantial progress has been made in the development of disease-modifying medications for multiple sclerosis (MS), a high percentage of treated patients still show progression and persistent inflammatory activity. Autologous haematopoietic stem cell transplantation (AHSCT) aims at eliminating a pathogenic immune repertoire through intense short-term immunosuppression that enables subsequent regeneration of a new and healthy immune system to re-establish immune tolerance for a long period of time. A number of mostly open-label, uncontrolled studies conducted over the past 20 years collected about 4000 cases. They uniformly reported high efficacy of AHSCT in controlling MS inflammatory disease activity, more markedly beneficial in relapsing-remitting MS. Immunological studies provided evidence for qualitative immune resetting following AHSCT. These data and improved safety profiles of transplantation procedures spurred interest in using AHSCT as a treatment option for MS. Objective: To develop expert consensus recommendations on AHSCT in Germany and outline a registry study project. Methods: An open call among MS neurologists as well as among experts in stem cell transplantation in Germany started in December 2021 to join a series of virtual meetings. Results: We provide a consensus-based opinion paper authored by 25 experts on the up-to-date optimal use of AHSCT in managing MS based on the Swiss criteria. Current data indicate that patients who are most likely to benefit from AHSCT have relapsing-remitting MS and are young, ambulatory and have high disease activity. Treatment data with AHSCT will be collected within the German REgistry Cohort of autologous haematopoietic stem CeLl trAnsplantation In MS (RECLAIM). Conclusion: Further clinical trials, including registry-based analyses, are urgently needed to better define the patient characteristics, efficacy and safety profile of AHSCT compared with other high-efficacy therapies and to optimally position it as a treatment option in different MS disease stages. Plain language summary: Autologous haematopoietic stem cell transplantation for multiple sclerosis Substantial progress has been made in the development of disease-modifying medications for multiple sclerosis (MS) during the last 20 years. However, in a relevant percentage of patients, the disease cannot completely be contained. Autologous haematopoietic stem cell transplantation (AHSCT) enables rebuilding of a new and healthy immune system and to potentially stop the autoimmune disease process for a long time. A number of studies documenting 4000 cases cumulatively over the past 20 years reported high efficacy of AHSCT in controlling MS inflammatory disease activity. These data and improved safety profiles of the treatment procedures spurred interest in using AHSCT as a treatment option for MS. An open call among MS neurologists as well as among experts in stem cell transplantation in Germany started in December 2021 to join a series of video calls to develop recommendations and outline a registry study project. We provide a consensus-based opinion paper authored by 25 experts on the up-to-date optimal use of AHSCT in managing MS. Current data indicate that patients are most likely to benefit from AHSCT if they are young, ambulatory, with high disease activity, that is, relapses or new magnetic resonance imaging (MRI) lesions. Treatment data with AHSCT will be collected within the German REgistry Cohort of autoLogous haematopoietic stem cell transplantation MS (RECLAIM). Further clinical trials including registry-based analyses and systematic follow-up are urgently needed to better define the optimal patient characteristics as well as the efficacy and safety profile of AHSCT compared with other high-efficacy therapies. These will help to position AHSCT as a treatment option in different MS disease stages. [ABSTRACT FROM AUTHOR]