1. Preparation of near-infrared light responsive upconversion nanoparticles TiO2/(Ca,Y)F2:Tm,Yb for photodynamic antitumor therapy.
- Author
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Zhou, Huan, Wang, Jie, Yang, Bing, Sun, Manna, Liang, Chunyong, Yang, Lei, Zhao, Xiaoyan, and Wang, Hongshui
- Subjects
NEAR infrared radiation ,PHOTODYNAMIC therapy ,PHOTON upconversion ,IRRADIATION ,FEMTOSECOND lasers ,NANOPARTICLES ,LABORATORY mice - Abstract
In this work, near-infrared light responsive upconversion nanoparticles TiO
2 /(Ca,Y)F2 :Tm,Yb were hydrothermally prepared for tumor control. Moreover, femtosecond laser was adopted to reduce particle size and aggregation of TiO2 /(Ca,Y)F2 :Tm,Yb, as a strategy to enhance its dispersity. In vitro studies of the biocompatibility and tumor control efficacy of TiO2 /(Ca,Y)F2 :Tm,Yb were carried out via co-culturing human pancreatic carcinoma cells (CFPAC-1). It was found in the absence of near-infrared light, TiO2 /(Ca,Y)F2 :Tm,Yb showed no toxicity to CFPAC-1 cells. On contrast, when exposed to near-infrared light, particles exhibited irradiation time, irradiation interval and particle concentration dependent suppression of CFPAC-1 cells proliferation along with portion of S phase cells increase. A nude mouse model with CFPAC-1 cells injection was established and TiO2 /(Ca,Y)F2 :Tm,Yb was subsequently applied for in vivo tumor control. A 15 days tracking confirmed the antitumor capability of near-infrared light excited TiO2 /(Ca,Y)F2 :Tm,Yb. Overall, we anticipate that the here-introduced TiO2 /(Ca,Y)F2 :Tm,Yb can serve as an effective agent for photodynamic antitumor therapy. [ABSTRACT FROM AUTHOR]- Published
- 2023
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