1. Signal intensity change on unenhanced T1-weighted images in dentate nucleus and globus pallidus after multiple administrations of gadoxetate disodium: an intraindividual comparative study.
- Author
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Conte, Giorgio, Preda, Lorenzo, Cocorocchio, Emilia, Raimondi, Sara, Giannitto, Caterina, Minotti, Marta, Piano, Francesca, Petralia, Giuseppe, Ferrucci, Pier, Bellomi, Massimo, De Piano, Francesca, and Ferrucci, Pier Francesco
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DENTATE nucleus ,GLOBUS pallidus ,MAGNETIC resonance imaging ,MELANOMA ,ADJUVANT treatment of cancer ,GADOLINIUM ,PATIENTS - Abstract
Purpose: To investigate whether there is an increased signal intensity (SI) of dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance imaging (MRI), in patients who had undergone multiple administrations of gadoxetate disodium.Materials and Methods: We retrospectevely included stage III melanoma patients, who had been previously enrolled in a trial of adjuvant therapy and who had undergone whole-body contrast-enhanced MRIs with gadoxetate disodium every three months for their follow-up. The SI ratios of DN-to-pons and GP-to-thalamus on unenhanced T1-weighted images were calculated. The difference in SI ratios between the first and the last MRI examinations was assessed and a linear mixed model was performed to detect how SI ratios varied with the number of administrations.Results: Eighteen patients were included in our study. The number of gadoxetate disodium administrations ranged from 2 to 18. Paired t-test did not show any significant difference in DN-to-pons (p=0.21) and GP-to-thalamus (p=0.09) SI ratios by the end of the study. DN-to-pons SI ratio and GP-to-thalamus SI ratio did not significantly increase with increasing the number of administrations (p=0.14 and p=0.06, respectively).Conclusion: Multiple administrations of gadoxetate disodium are not associated with increased SI in DN and GP in the brain.Key Points: • Gadolinium may deposit in the human brain after multiple GBCA administrations. • Gadolinium deposition is associated with increased T1W signal intensity • Increase in signal intensity is most apparent within the DN and GP • Multiple administrations of gadoxetate disodium do not increase T1W signal. [ABSTRACT FROM AUTHOR]- Published
- 2017
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