1. The extent of local tumor invasion predicts prognosis in stage I nasal natural killer/T-cell lymphoma: a novel T staging system for risk stratification.
- Author
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Bi, Xi-wen, Zhang, Wen-wen, Li, Zhi-ming, Huang, Jia-jia, Xia, Yi, Sun, Peng, Wang, Yu, and Jiang, Wen-qi
- Subjects
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CANCER invasiveness , *KILLER cells , *T-cell lymphoma , *TUMOR classification , *CANCER remission , *RADIOTHERAPY , *CANCER chemotherapy , *PROGNOSIS , *PATIENTS - Abstract
A heterogeneous treatment response and prognosis exists among patients with Ann Arbor stage I natural killer/T-cell lymphoma (NKTCL), and further risk stratification is required to identify high-risk patients. Here, we assessed the extent of local tumor invasion (LTI) in 185 patients with Ann Arbor stage I primary nasal NKTCL and proposed a novel four-level T staging system. We found that a more advanced T stage was associated with a significantly lower rate of complete remission (CR) after chemotherapy and a marginally lower rate of CR after radiotherapy. While patients with no LTI (T) or mild LTI (T) presented with similar 5-year overall survival (OS; 83.6 % vs. 86.0 %, P = 0.990), those with moderately or highly advanced local disease (T or T) had significantly worse survival (5-year OS was 63.3 % and 35.1 %, respectively). A more advanced T stage (T or T) was an independent prognostic factor for both OS and progression-free survival (PFS) in the Cox regression model. In addition, patients with T or T disease experienced locoregional failure more frequently than those with T or T disease, and patients with T disease had a significantly higher risk of distant failure. Our data demonstrated that the T staging system, based on the extent of LTI, could serve as an effective clinical parameter for further risk stratification among patients with primary nasal Ann Arbor stage I NKTCL. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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