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Fossil leaves of Lagerstroemia (Lythraceae) are described from the Siwalik deposits (middle Miocene) of Kathgodam, Uttarakhand, India. The fossil records of the Lythraceae indicate its worldwide distribution in the Cenozoic. The family had its widest distribution during the Miocene but became less widespread during the Pliocene, followed by range expansion during the Quaternary. The present leaf fossil, along with the previous fossil records of Lagerstroemia, indicates that the genus followed the same pattern of expansion and retraction as the entire family Lythraceae suggesting that both the genus and the family adapted in similar ways. The fossil plant assemblage from the Lower Siwalik deposits indicates warm and humid climate with plenty of rainfall in the region during the depositional period. [ABSTRACT FROM AUTHOR]

Objective: To study the clinical profile and mutation spectrum of Hunter syndrome. Methods: Evaluation of 18 cases of Hunter syndrome from 17 families was done. Mutation analysis of Iduronate sulfatase (IDS) gene was done in 9 families, and mothers of four affected children with no family history Results: Joint contracture, hepatomegaly and radiological changes were present in all children. 6 (33%) children had normal cognitive function at presentation. Point mutations were identified in all the 9 families for whom mutation analysis was done. Among 4 mothers tested from families without any family history, 2 (50%) were found to be carriers. Conclusion: Accurate etiological diagnosis by mutation analysis of IDS gene is important in Hunter syndrome. [ABSTRACT FROM AUTHOR]