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The key to intelligent fault diagnosis for transformer is to find relevant dissolved gas characteristics with the capability of representing different types of faults. However, the existing problem is that using a single traditional ratio method as the inputs of classification module cannot obtain high classification performance. Therefore, a fault diagnosis method for transformer based on neighborhood component analysis (NCA) and capuchin algorithm (CapSA)-regularized extreme learning machine (RELM) is proposed. Firstly, 21-dimensional features of the oil-immersed transformer are extracted based on the traditional ratio methods such as IEC three-ratio and Roger's ratio. Secondly, The NCA is used to select the feature to obtain an effective 6-dimensional feature. Then, these features are utilized as the input of the RELM model for training, and the parameters of model are optimized by CapSA. Finally, the feasibility and validity of the proposed method are verified by actual data sets collected from previous publications. The experimental results show that the proposed method has higher diagnostic precision and stability. [ABSTRACT FROM AUTHOR]

The 6005A aluminum alloy extrusion profiles are widely used in China Railway High-speed trains and mainly welded by metal-inert gas welding. The coarse-grain layer covering the profiles leads to the formation of liquation cracks and deteriorates the mechanical properties of the welded joints. In addition, the weld reinforcement has negative effects on the fatigue life. To improve the mechanical properties of the welded joints, a novel hybrid milling-friction stir processing (HMFSP) tool is developed. The surficial coarse grains and intergranular eutectic could be eliminated by the tool, which suppressed the formation of liquation cracks. Meanwhile, the weld reinforcement was removed simultaneously and the stress concentration near the weld toe was eliminated. The average grain size of the affected zone was refined to 5.7 μm and the tensile strength of the welded joints increased by 10% after HMFSP. Moreover, a 62.1% prolongation of the fatigue life was obtained. [ABSTRACT FROM AUTHOR]

Background: Implants immediately loaded full-arch prosthesis in maxilla is always a challenge, especially when the zone 2 is extremely defected. To achieve a satisfying result, different therapeutic alternatives have been proposed, such as zygomatic implant, pterygoid implant; however, precise surgical skills limited its application. Case presentation: This study reported a case that an edentulous patient was treated with a new technique, two axial implants and four tilted implants supporting an immediate fixed denture, extruding the cortical bone of the anterior wall of the maxillary sinus to establish the primary stability. Conclusions: Two-year follow-up proves that it is a viable choice. Meanwhile, a reliable method for its saving time and money and low level of discomfort for patients is presented. [ABSTRACT FROM AUTHOR]

Knee osteoarthritis (OA) is the most prevalent type of OA, and Toll-like receptor 7 (TLR7) may lead to the pathogenesis of OA. Recently, X-linked TLR7 polymorphism has been confirmed to be associated with arthritis. However, there is a lack of studies on TLR7 gene polymorphism associated with knee OA susceptibility. The current study aimed to determine whether TLR7 gene polymorphism is associated with the risk of knee OA. Genotyping of two polymorphic sites (rs3853839 and rs179010) in the TLR7 gene was performed in 252 OA patients, and 265 healthy controls using the SNaPshot sequencing technique. Data were analyzed statistically by Chi-square tests and logistic regression. Rs3853839-C allele showed frequencies of 28% and 27% in the healthy control and female knee OA groups, respectively. The differences were not statistically significant (P > 0.05). The rs3853839-CG genotype frequency was significantly lower in the female knee OA group as compared to the healthy control group (OR 0.60; 95%CI 0.36–0.99; P = 0.044). In the male hemizygote population, the rs3853839-CC showed significantly lower frequencies in the male knee OA group as compared to the healthy control group (OR 0.35; 95%CI 0.17–0.71; P = 0.0025). Regarding rs179010, there were no differences in the genotype distribution and allele frequencies between OA patients and healthy subjects under any models (P > 0.05). Stratified analysis showed that the frequency of the rs3853839-CG genotypes was lower in high Kellgren-Lawrence grades (KLG) (OR 0.48; 95%CI 0.21–1.08; P = 0.066), and significantly lower in OA patients with effusion synovitis (OR 0.38; 95%CI 0.17–0.88; P = 0.013). TLR7 rs3853839 polymorphism may play a role in the susceptibility of knee OA in the Chinese Han Population and may be associated with OA severity and the risk of effusion synovitis in Knee OA. [ABSTRACT FROM AUTHOR]

This study was designed to investigate the effect of 650-nm low-level laser irradiation (LLLI) as an adjunctive treatment of experimental periodontitis. To investigate possible LLLI-mediated anti-inflammatory effects, we utilized an experimental periodontitis (EP) rat model and analyzed c-Jun, c-Fos, ICAM-1, and CCL2 gene expressions on PB leukocytes and in the gingival tissue. Total RNA was isolated from the gingivae and peripheral blood (PB) leukocytes of normal, EP, scaling, and root planing (SRP)-treated EP and LLLI + SRP-treated EP rats, and gene expressions were analyzed by real-time PCR. The productions of c-Jun, c-Fos, ICAM-1, and CCL2 in gingivae were analyzed immunohistochemically. Tartrate-resistant acid phosphatase (TRAP) staining was used to determine osteoclast activity in alveolar bone. The c-Jun and ICAM-1 messenger RNA (mRNA) levels were significantly decreased in the EP rat gingival tissue treated by SRP + LLLI than by SRP, the c-Jun, ICAM-1, and c-Fos mRNA levels on PB leukocytes reduced after LLLI treatment but did not show any significant differences in both groups. There was no significant difference in CCL2 mRNA levels on PB leukocytes and in gingivae between the SRP + LLLI and the SRP groups. The c-Fos mRNA levels in gingivae did not show significant difference in both groups. Immunohistochemistry showed that the CCL2, ICAM-1, c-Jun, and c-Fos productions were significantly reduced in rats of the SRP + LLLI group compared with the only SRP group. LLLI significantly decreased the number of osteoclasts as demonstrated by TRAP staining. The 650-nm LLLI might be a useful treatment modality for periodontitis. [ABSTRACT FROM AUTHOR]

After publication of our article [1] we realized that we had not acknowledged that some of the text overlaps with a previous publication [2]. We apologize to readers for this error. [ABSTRACT FROM AUTHOR]