Marijt, Koen A., Van Der Burg, Sjoerd H., and van Hall, Thorbald
Subjects
*PEPTIDES, *HISTOCOMPATIBILITY class I antigens, *T cells, *ANTIGENS, *CANCER
Abstract
The intracellular peptide pump TAP feeds antigenic peptides for loading onto HLA class I molecules, and its down-modulation is a frequent immune evasion mechanism in human cancers. Two recent papers describe which 'hidden' antigens we might exploit to target these escaped cancer variants by CD8 T cells. These unTAPped peptides are now ready for clinical testing. [ABSTRACT FROM AUTHOR]