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Hand, foot, and mouth disease (HFMD) is a global infectious disease severely threatening children's health. It has been recognized that climate factors play an important role in the transmission of HFMD. In this paper, the bootstrap test in the geographically weighted regression (GWR) literature is extended to geographically and temporally weighted regression (GTWR) models for identifying homogeneous explanatory variables and spatiotemporally heterogeneous ones. The resulting mixed GTWR model is then used to investigate spatiotemporal effect of climate factors on the HFMD incidence in Inner Mongolia, China, a provincial autonomous region with extensive area and different climatic conditions. The results demonstrate that the effect of relative humidity is global over space and time, while that of air temperature, air pressure and wind speed varies spatiotemporally. The extended bootstrap test provides a solid statistical basis for model selection. The findings from the study may provide not only a deep understanding of spatiotemporal variation characteristics of the climatic effect on the HFMD incidence, but also some useful evidences for taking measures of the disease prevention and control at the county level in different seasons. [ABSTRACT FROM AUTHOR]