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An introduction is presented in which the editor discusses articles in the issue on topics including how issues such as trust in government shape responses to contact tracing, the policy responses to COVID-19 that have exacerbated social divisions and undermined social justice and the ethnic inequalities in exposure to risk among health works in the British National Health Service (NHS).

Determine the inhibition mechanism through which cyclosporine inhibits the uptake and metabolism of atorvastatin in fresh rat hepatocytes using mechanistic models applied to data generated using a high throughput oil spin method. Atorvastatin was incubated in fresh rat hepatocytes (0.05–150 nmol/ml) with or without 20 min pre-incubation with 10 nmol/ml cyclosporine and sampled over 0.25–60 min using a high throughput oil spin method. Micro-rate constant and macro-rate constant mechanistic models were ranked based on goodness of fit values. The best fitting model to the data was a micro-rate constant mechanistic model including non-competitive inhibition of uptake and competitive inhibition of metabolism by cyclosporine (Model 2). The association rate constant for atorvastatin was 150-fold greater than the dissociation rate constant and 10-fold greater than the translocation into the cell. The association and dissociation rate constants for cyclosporine were 7-fold smaller and 10-fold greater, respectively, than atorvastatin. The simulated atorvastatin-transporter-cyclosporine complex derived using the micro-rate constant parameter estimates increased in line with the incubation concentration of atorvastatin. The increased amount of data generated with the high throughput oil spin method, combined with a micro-rate constant mechanistic model helps to explain the inhibition of uptake by cyclosporine following pre-incubation. [ABSTRACT FROM AUTHOR]

As urban planners focus on creating more sustainable cities, there is an increasing need to plan for other species. Found in around 40% of Australian households, dogs have a growing, legitimate presence in urban culture and society. Dogs however remain a neglected subject of urban planning scholarship and practice. This paper critically examines the practice of strategic planning as it applies to dogs in the urban context of Melbourne, Australia. Through a narrative of the institutional voices of practising strategic planners and other institutional discourse of local government, this paper provides a critical examination of how strategic planners shape – and limit – the concern of urban planning. This paper provides a deeply critical glimpse into the modus operandi of the strategic planner negotiating controversy on planning’s frontier. Institutional ontology is shown to dominate any efforts of strategic planners to effect change to urban planning’s field of concern.ABSTRACT FROM PUBLISHERCopyright of Australian Planner is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. [ABSTRACT FROM AUTHOR]

As urban planners focus on creating more sustainable cities, there is an increasing need to plan for other species. Found in around 40% of Australian households, dogs have a growing, legitimate presence in urban culture and society. Dogs however remain a neglected subject of urban planning scholarship and practice. This paper critically examines why urban planners exclude dogs as subjects of their plans through the voices of practising strategic planners in the urban context of Melbourne, Australia. This paper characterises planning as being governed by two dimensions – the ontological and epistemological – and finds that the actions of planners in excluding dogs from consideration concerns the functioning of their ontologies of gatekeeper and practitioner as they negotiate and reshape the frontier of planning and its field of concern. The importance of anthropocentrism in governing how planners exclude dogs from planning in practice is shown to be profound. [ABSTRACT FROM PUBLISHER]

Induced polarisation (IP) is a common geophysical method of exploration for disseminated sulphides. However, in areas with deep (>200 m) and conductive (10 Ωm or less) cover, the technique is less successful as it requires a significant transmitter source and large-offset dipoles. An alternative approach is to use natural-variations in Earth’s external magnetic field as the polarising source of the signal, known as natural-field IP. This paper presents a study of extracting IP information from electrical dipole observations during a broadband magnetotelluric (MT) program with a 9 km by 9 km grid of 100 sites above the Vulcan IOCG deposit beneath 750 m of cover, ∼40 km north of the Olympic Dam IOCG mine in South Australia. Inter-site transfer functions between 95 sites and five reference sites at the southeast and southwest corners of the grid were computed to determine a phase shift between horizontal electric fields in the bandwidth of 1–100 s period. Phase shifts of up to – 5 degrees were centred on a region of brecciated hematite where drill holes intersected pyrite, and an inferred fault-zone from passive seismics that marks the boundary between upper crust that is resistive (>100 Ω.m) with high magnetic susceptibility to the south of the fault, and a region of conductive crust (<10 Ω.m) which is low magnetic susceptibility. Our study suggests that the natural-field IP method can identify regions of polarizable minerals beneath deep cover where artificial power sources cannot be feasibly deployed. Such surveys are cheaper, safer, and easier to deploy as only receivers are required, and 3D coverage can be obtained as the source-field is of much larger dimension than the survey array. In addition, the natural-field IP signals are observed as part of the MT program so that both electrical resistivity and polarisation parameters can be determined. [ABSTRACT FROM AUTHOR]