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Purpose: To evaluate prognostic factors and survival of patients with sebaceous carcinoma of the eyelid through a population-based analysis. Methods: A total of 940 patients with primary sebaceous carcinoma of the eyelid were derived from the Surveillance, Epidemiology, and End Results (SEER) database in the United States from 1973 to 2013. Kaplan–Meier univariate analysis and Cox Regression multivariate analysis were performed to examine prognostic factors in overall survival (OS). 5- and 10-year survival rates, median survival, and prognostic variables with statistical significance were measured. Results: Kaplan-Meier analysis showed that OS is 66% and 44% at 5 years and 10 years respectively. Median OS is 9.4 years. Multivariate Cox regression analysis demonstrated that independent prognostic factors for OS are age at diagnosis (HR = 4.61 [95% CI 1.93–11.0], P = 0.001), surgical treatment (HR = 0.196 [95% CI 0.07–0.55], P = 0.002), combined surgical and radiation treatment (HR = 0.227 [95% CI 0.06–0.81], P = 0.023), and greater tumor size at diagnosis (HR = 3.381, [95% CI 1.77–6.45], P < 0.001). Conclusion: We report the largest population study to date to evaluate prognostic factors of patients with sebaceous carcinoma of the eyelid. Multivariate analysis shows that older age, and greater tumor size correlate with decreased overall survival, whereas surgical treatment or combined surgical and radiation treatment correlate with increased overall survival. Interestingly, tumor grade, lymph node involvement, and distant extent of tumor have not demonstrated to be independent prognostic factors for overall survival. [ABSTRACT FROM AUTHOR]

This article contributes to ongoing debate about the effectiveness of information-based policy tools by evaluating environmental information posters using a novel eye-tracking method to examine viewing behavior. Findings from a multi-method study involving 93 students indicate that: (1) slogans are typically the first thing that subjects fixate on when presented with an information poster, (2) recall of poster content is highest when positive slogans and negative images are included, and (3) posters should be targeted to different audiences for maximum effectiveness. These findings indicate that eye-tracking technologies can be incorporated into designing more effective information-based policy instruments by examining behavior. [ABSTRACT FROM AUTHOR]