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Cardiovascular disease is the leading cause of death worldwide, and it's of great importance to understand its underlying mechanisms and find new treatments. Sphingosine 1-phosphate (S1P) is an active lipid that exerts its effects through S1P receptors on the cell surface or intracellular signal, and regulates many cellular processes such as cell growth, cell proliferation, cell migration, cell survival, and so on. S1PR modulators are a class of modulators that can interact with S1PR subtypes to activate receptors or block their activity, exerting either agonist or functional antagonist effects. Many studies have shown that S1P plays a protective role in the cardiovascular system and regulates cardiac physiological functions mainly through interaction with cell surface S1P receptors (S1PRs). Therefore, S1PR modulators may play a therapeutic role in cardiovascular diseases. Here, we review five S1PRs and their functions and the progress of S1PR modulators. In addition, we focus on the effects of S1PR modulators on atherosclerosis, myocardial infarction, myocardial ischaemia/reperfusion injury, diabetic cardiovascular diseases, and myocarditis, which may provide valuable insights into potential therapeutic strategies for cardiovascular disease. [ABSTRACT FROM AUTHOR]

This study investigates how disclosure type and disclosure time have impacts on organizational reputation when medical negligence occurs and whether the mechanism of concealment intention and offensiveness attribution serially mediates the relationship between stealing thunder and organizational reputation. The study also explores the moderating effects of an organizational/industrial history of crisis concealment. Based on three scenario-based experiments, the results demonstrate that, compared to a media disclosure, the self-disclosure effect elicits lower concealment intention and higher organizational reputation. The longer the disclosure time, the higher the concealment intention and the lower the organizational reputation. The findings also show that the effect of disclosure type on organizational reputation is mediated serially by concealment intention and offensiveness attribution. In addition, for hospitals with an organizational history of crisis concealment, the effect of stealing thunder on concealment intention and organizational reputation was weaker. Further, under an industrial history of crisis concealment, the public perceived lower concealment intention and higher organizational reputation when the media disclosed the current crisis case. [ABSTRACT FROM AUTHOR]

We consider the question of language diffusion and examine the latest attempt to popularize the Ukrainian language. This effort has been undertaken by the Ukrainian government since 1991. While sociological studies report positive dynamics in Ukrainian language dissemination, in practice, the language adoption progress might be slower than reported. We test this hypothesis using google trends web search data. We apply a Bayesian beta regression model and show that the proposed model is appropriate. The results suggest that the Ukrainian language popularization policy is successful and that the 2022 Russian invasion has considerably intensified the usage of the Ukrainian language. [ABSTRACT FROM AUTHOR]

In this study, a remanence detection technology and double-layer sensor crack depth quantitative method for the on-line detection of microcracks on the surface of steel wire using remanence were developed. First, an instrument and a verification experiment were designed. Second, the magnetic signal of the prefabricated crack was analysed, and a defect recognition algorithm was designed. Finally, a detection instrument was applied in the industrial field. The results indicate that the practical application of remanence detection technology is feasible, the recognition algorithm is accurate and reliable, and a minimum crack depth of 0.078 mm can be detected. The magnetic anomaly amplitude difference of the double-layer sensor is positively correlated with the crack depth. The maximum error rate of the quantitative formula for the depth obtained by the fitting method is 10.95%. However, distinguishing the tilt direction of the crack from the shape of the notch remains a challenge for remanence detection technology. [ABSTRACT FROM AUTHOR]

Township health centers play a cornerstone role in the primary healthcare in China while it's development is largely limited by the brain drain. Job satisfaction is closely related to brain drain, investigating the relevant factors of job satisfaction can provide strategies to reduce brain drain. This research was conducted in Huangpi, China. Convenience sampling methods and self-administereded questionnaires were used. We collected 1370 valid samples, with an effective rate of 97.72%. Descriptive statistics are used to describe sociodemographic information. The Pearson Chi-square statistical was used to test the binary association between job satisfaction and another categorical variable. All the sociodemographic information was applied to the binary logistic regression model using the stepwise selection method. The mean age was 36.98 (SD = 9.84), factors that affect job satisfaction include educational background (x2 = 7.99, p< 0.05), marital status (x2 = 8.96, p< 0.05, monthly income (x2 = 51.43, p< 0.01), hire form (x2 = 7.64, p< 0.05), hours worked per week (x2 = 33.48, p< 0.01), parent had a stable job (x2 = 10.65, p< 0.01). Government and management should consider the impact of current policies on job satisfaction. Increasing the welfare of healthcare staff and promoting equity are potential strategies for improving low levels of job satisfaction. [ABSTRACT FROM AUTHOR]

The prognostic nutrition index (PNI), based on the serum lymphocyte counts and albumin levels, has been introduced as a prognostic factor in various cancer. In the present study, we explore the prognostic significance of PNI in patients with renal cell carcinoma (RCC). A literature search of all publications was conducted using the Cochrane library, PubMed and Embase databases from inception to April 2020. A total of 12 studies consisting of 7,391 patients were enrolled in the present study. We found that low pretreatment PNI is significantly correlated to poor survival, including overall survival (OS) (P < 0.001), cancer-specific survival (CSS) (P = 0.002), progression-free survival/recurrence-free survival/disease-free survival (PFS/RFS/DFS) (P < 0.001). The age (P < 0.001), clear cell histology (P = 0.044), T3–T4 (P = 0.049), and Fuhrman grade 3–4 (P = 0.024) were significantly differed in the low and high pretreatment PNI group. In summary, low pretreatment PNI was associated with adverse clinicopathological features in patients with RCC. Besides, low pretreatment PNI was also an unfavorable factor of OS, CSS, and PFS/RFS/DFS in RCC patients, which could serve as an unfavorable factor. More studies with large participants are required to verify our results. Supplemental data for this article is available online at https://doi.org/10.1080/01635581.2021.1931702 [ABSTRACT FROM AUTHOR]

An all-dielectric metamaterial absorber based on water resonator encapsulated in resin container is proposed. The absorber can afford the maximum absorption up to 98% at 190 GHz, as well as the wide absorption frequency range from 115 GHz to 300 GHz and a nearly 90% relative absorption bandwidth. The role of water resonator sealed in the resin shell in improving absorption capability is demonstrated by the comparison result that the proposed absorber is superior to pure water or pure resin absorber with the same dimension and interpreted by a further study on the fields and power loss density distributions. Moreover, the proposed absorber can remain excellent absorption performance even for the oblique incidence with large angles. Besides the outstanding absorption performance, the proposed absorber has the advantage of low cost endowed by the use of water, which makes it promising for EM compatibility in the millimetre-wave and high-power cases. [ABSTRACT FROM AUTHOR]

A gold-coated magnetic nanoparticle (MNPs@Au) based label-free electrochemical impedance spectroscopy (EIS) sensor is reported for determining vascular endothelial growth factor (VEGF) in cell culture media. VEGF antibodies (Ab) were modified on MNPs@Au to construct an Ab-bound magnetic complex (MNPs@Au-Ab) that was magnetically immobilized on a magnetic glassy carbon electrode (mGCE). The VEGF is captured on the MNPs@Au-Ab/mGCE, leading to increased electron-transfer resistance (Ret) utilized for the determination of VEGF. Combining the highly efficient immobilization of antibodies on magnetic nanocomposites with the high sensitivity of electrochemical impedance spectroscopy, an excellent dynamic range for the VEGF concentration from 1.0 × 10−2 to 1.0 × 104 ng mL−1 was obtained with a detection limit of 2.43 pg mL−1. Quantitative determination and the investigation of the secretion of VEGF by various cells were also conducted. VEGF released by cancer cells (MDA-MB-231 cells and HCT116 cells) was significantly higher than for normal cells (L02 cells), which matched well with an enzyme linked immunosorbent assay (ELISA). These results show that the secretion of VEGF is associated with the metastatic level of cells. The reported sensor is expected to be applied in studies of cancer and tumor metastasis. [ABSTRACT FROM AUTHOR]

Two new isoquinoline alkaloids (1 and 2) along with fourteen known alkaloids (3–16) were isolated from Corydalis racemosa (Thunb.) Pers. Their structures were elucidated by analyzing spectroscopic and spectrometric data (NMR, UV, IR, and MS) and comparing their spectroscopic, spectrometric and physicochemical data with the values archived in the literature. The absolute configurations of new compounds were determined via X-ray crystallographic assay and electronic circular dichroism calculations. Acetylcholinesterase (AChE) inhibitory activity of all compounds was evaluated. Compounds 5, 6, 9, 11, and 12 exhibited inhibitory activity against AChE with IC50 values ranged from 10.2 to 63.4 μM. [ABSTRACT FROM AUTHOR]

Thiosugars are not only playing important roles in saccharide synthesis but also occur widely in pharmaceutical agents, natural products and S-glycopeptides/proteins, and possess critical biological activities. Many methods have been developed for the syntheses of thiosugars, but most of them adopted saturated-glycosyl donors to give 1-thiosugars only. With the development of olefin-chemistry and transition metal catalysis, numerous protocols of thiosugar synthesis were developed with 1,2-unsaturated-glycosyl donors (glycals) giving different stereoselectivity and regioselectivity. In this review, we have summarized the synthetic methods of thiosugars using glycal donors based on promoters/catalysts, including main-group, transition metal, rare-earth and solid-supported catalysts. [ABSTRACT FROM AUTHOR]

Dysregulated microRNAs (miRNAs) are involved in carcinoma progression, metastasis, and poor prognosis. We demonstrated that in nasopharyngeal carcinoma (NPC), transactivated MIR106A-5p promotes a malignant phenotype by functioning as a macroautophagy/autophagy suppressor by targeting BTG3 (BTG anti-proliferation factor 3) and activating autophagy-regulating MAPK signaling. MIR106A-5p expression was markedly increased in NPC cases based on quantitative real-time PCR, miRNA microarray, and TCGA database analysis findings. Moreover, MIR106A-5p was correlated with advanced stage, recurrence, and poor clinical outcomes in NPC patients. In addition to three-dimensional cell culture assays, zebrafish and BALB/c mouse tumor models revealed that overexpressed MIR106A-5p targeted BTG3 and accelerated the NPC malignant phenotype by inhibiting autophagy. BTG3 promoted autophagy, and its expression was correlated with poor prognosis in NPC. Attenuation of autophagy, mediated by the MIR106A-5p-BTG3 axis, occurred because of MAPK pathway activation. MIR106A-5p overexpression in NPC was due to increased transactivation by EGR1 and SOX9. Our findings may lead to novel insights into the pathogenesis of NPC. Abbreviations: ACTB: actin beta; ATG: autophagy-related; ATG5: autophagy related 5; BLI: bioluminescence; BTG3: BTG anti-proliferation factor 3; CASP3: caspase 3; ChIP: chromatin immunoprecipitation; CQ: chloroquine; Ct: threshold cycle; DAPI: 4ʹ,6-diamidino-2-phenylindole; DiL: 1,1ʹ-dioctadecyl-3,3,3ʹ,3ʹ-tetramethylindocarbocyanine perchlorate; EBSS: Earle's balanced salt solution; EGR1: early growth response 1; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GEO: Gene Expression Omnibus; GFP: green fluorescent protein; IF: immunofluorescence; IHC: immunohistochemistry; ISH: in situ hybridization; MAP1LC3B: microtubule associated protein 1 light chain 3 beta; MIR106A-5p: microRNA 106a-5p; miRNAs: microRNAs; MKI67: marker of proliferation ki-67; mRNA: messenger RNA; MTOR: mechanistic target of rapamycin kinase; NPC: nasopharyngeal carcinoma; qRT-PCR: quantitative real-time PCR; siRNA: small interfering RNA; SOX9: SRY-box transcription factor 9; SQSTM1: sequestosome 1; TCGA: The Cancer Genome Atlas; WB: western blot. [ABSTRACT FROM AUTHOR]

The protein phosphatase 2C (PP2C) gene family, which is known to participate in cellular processes, is one of the most conserved plant-specific gene families that regulate signal transduction in eukaryotic organisms. However, the PP2C gene family of Glycyrrhiza uralensis Fisch. has not yet been systematically characterized. In this study, 76 PP2C genes of G. uralensis (GuPP2Cs) were identified. Phylogenetic analysis divided these GuPP2Cs into 12 subfamilies. The gene structure and protein motifs of the GuPP2Cs were then analysed. The analysis of the transcriptomic data of the GuPP2Cs revealed that nine genes were highly sensitive to abscisic acid (ABA) stress and might respond to ABA treatment. These nine genes were validated via quantitative real-time polymerase chain reaction. This study provides a foundation for future studies on the functional PP2C genes of G. uralensis and the improvement of the cultivation and quality of G. uralensis. [ABSTRACT FROM AUTHOR]

Few studies have concentrated on the prevalence and related factors of depression and falls among the elderly living in rural communities of Guangzhou. A total of 335 participants aged ≥60 years were recruited by simple random sampling method. A structural equation model was applied to determine interrelationships between depression, falls and other variables. As high as 27.5% and 23.3% participants had reported depressive symptoms and falls, respectively. The path analysis showed the total effect (β = −0.58) of depression on quality of life (QOL) consisted of a direct effect (β = −0.51) and an indirect effect (β = −0.07), which was mediated by family function and number of falls, and the R2 was 0.36. The model fit indices were χ2/df = 1.096, P > 0.05, Root Mean Square Error of Approximation (RMSEA) = 0.017, Tucker–Lewis Index (TLI) = 0.998 and Comparative Fit Index (CFI) = 0.999. Depression and falls were prevalent among the elderly living in rural communities of Guangzhou city. Pay attention to strengthen family function and prevent falls may prevent depression and improve the QOL among the elderly. [ABSTRACT FROM AUTHOR]

Two new benzophenone glycosides, aquilarisides A (1) and B (2), together with six known analogues (3-8) were isolated from the pericarps of Aquilaria yunnanensis S. C. Huang. Their structures were elucidated on the basis of 1D and 2D NMR and mass spectroscopic analyses, and the absolute configuration of compound 1 was determined by experimental and calculated electronic circular dichroism (ECD) spectra. Anti-inflammatory activities of all compounds 1–8 were evaluated for their inhibitory activities against lipopolysaccharide (LPS)-stimulated induced nitric oxide (NO) production in RAW 264.7 cells using the Griess assay. Compound 2 indicated a weak inhibition of NO production. [ABSTRACT FROM AUTHOR]

The imidacloprid was mineralized by heterogeneous photo-Fenton process in a three-phase fluidized bed reactor using waste iron oxide as catalyst. The effects of catalyst loading, dosage of H2O2 and pH were investigated to determine the optimal experiments conditions. The results revealed that TOC removal efficiency increases with an increase in H2O2 dosage of up to 105.0 mM, an increase in catalyst dosage from 1.0 to 5.0 g L−1, and a decrease in pH from 5.0 to 3.5. Under the optimal conditions, 97.7% TOC removal was achieved in 6 h under 254-nm UV irradiation. Moreover, recycling experiments indicated that the waste iron oxide had a good stability and the TOC removal of pesticide yielded more than 80% under the fourth recycles. [ABSTRACT FROM AUTHOR]

Background: Esophageal cancer is a highly aggressive neoplasm. Targeted therapy has been proven to be a promising way for cancer therapy. Here, we report a novel anti-CD147 antibody for esophageal cancer therapy, which is a chimeric antibody with modified glycoform in Fc region. Methods: ADCC assay was used to explore the antitumor efficacy of Metuzumab against esophageal cancer in vitro. Wound healing assay and Boyden Chamber invasion assay were performed to explore whether Metuzumab could inhibit migration and invasion of esophageal cancer in vitro. Insulin-like growth factors 1 (IGF-1) and PI3k/Akt was assayed for elaborating antagonistic mechanism of Metuzumab in migration and invasion of esophageal cancer cells. Subcutaneous xenograft nude mouse model was used to investigate the antitumor efficacy of Metuzumab against esophageal cancer in vivo. The esophageal cancer tissue microarrays (TMA) was examined for identification of association of CD147 with lymph node metastasis, and the footpad xenograft nude mouse model was used to explore whether Metuzumab could inhibit lymph node metastasis of esophageal cancer in vivo. Results: The results showed that Metuzumab exhibited higher ADCC compared to the wild type antibody cHAb18. Metuzumab inhibited migration and invasion of esophageal cancer through blockade of CD147 in vitro. The results of Western blot showed Metuzumab might inhibit migration and invasion of esophageal cancer cells through suppressing activation of PI3k/Akt and expression of IGF-1. Experiments in vivo showed that Metuzumab exhibited significant antitumor efficacy and inhibited lymph node metastasis of esophageal cancer in xenograft models. The immunochemical staining of TMA showed CD147 was high-expressed on various kinds of esophageal cancer tissues and associated with the grade of lymph node-metastasis. Conclusions: The in vitro and in vivo study demonstrated dual effects of Metuzumab in effectively mediating ADCC by activating effector cells, and inhibiting metastasis of esophageal cancer through blockade the function of CD147, providing justification for moving Metuzumab forward to clinical development in esophageal cancer. [ABSTRACT FROM AUTHOR]

Large amounts of CO2 and dust particles coming from power plant flue need to be captured and removed before flue is discharged into the air. In present work, absorption of carbon dioxide in aqueous N-methylidiethanolamine (MDEA) solution coupling dust suppression has been studied in an atomization absorption column, with MDEA concentrations ranging from 0.1 to 0.5mol/L, and with atomization frequencies ranging from 50 to 80 HZ. The obtained experimental results show that absorption rate of CO2 in aqueous MDEA solution can be enhanced when the absorption process couples a dust suppression one under the condition of atomization. The reason for it is attributed to the adsorption of droplets on the solid particles which restrains the amount of entrainment and makes more droplets contact with gas so as to increase effective mass transfer area, thus resulting in the increase of CO2 absorption rate. The range of obtained enhancement factor is from 1.1 to 1.7. Mass transfer enhancement factor increases with the increase of MDEA concentration and atomization frequency at a certain range. Effective mass transfer areas and entrainment ratios suppressed have been calculated based on theoretic research. The results calculated agree with our experimental phenomena, and support the enhancement mass transfer mechanism proposed. [ABSTRACT FROM AUTHOR]

Objective: The objective of this study was to enhance the solubility and bioavailability of Lupeol. Methods: Utilizing a thin-film dispersion method, we prepared Lupeol-loaded PEGylated liposomes and Lupeol-loaded liposomes, which was characterized using SEM, mean diameter, PDI, zeta potential, and entrapment efficiency (EE). The EE, in vitro release, and stability of Lupeol-loaded PEGylated liposomes were detected using HPLC. In addition to the safety evaluation, the evaluation was carried out on HepG2 cells in vitro; the pharmacokinetics were carried out after i.v. in the rats. Results: The size, PDI, zeta potential, and EE of Lupeol-loaded PEGylated liposomes and Lupeol-loaded liposomes were 126.9 nm, 0.246, −1.97 mV, 87%; 97.23 nm, 0.25, 1.6 mV, 86.2%, respectively. Lupeol-loaded PEGylated liposomes showed the slow-release effect in vitro release experiments. Lupeol-loaded PEGylated liposomes offered significant advantages over other experimental groups in vitro studies, such as the highest inhibition rate and the highest apoptosis rate. We also found that Lupeol-loaded PEGylated liposomes blocked cells in the G2M phase. The pharmacokinetics result showed that the AUC of Lupeol-loaded PEGylated liposomes group was 3.2 times higher than free Lupeol group after i.v., the MRT and t1/2 values of Lupeol-loaded PEGylated liposomes (MRT = 6.09 h, t1/2 =12.94 h) showed improvements of 2.5 and 4.1 times compared to free Lupeol (MRT = 2.43 h, t1/2 = 3.16 h). Conclusion: The Lupeol-loaded PEGylated liposomes have successfully solved its poor hydrophilicity, low bioavailability. [ABSTRACT FROM AUTHOR]

Two new polyketides, penicilloxalones A (1) and B (2), together with 13 known compounds (3–15), were isolated from the ethyl acetate extract of the solid substrate fermentation cultures of the fungus Penicillium oxalicum MHZ153. The structures of the isolates were determined by spectroscopic analysis and comparison of their spectroscopic and physicochemical data with the literature values. Compounds 7 and 11 showed inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 values of 0.9 ± 0.2 μM and 87.9 ± 0.7 μM, respectively. [ABSTRACT FROM AUTHOR]

Osteoporosis is a disease where increased bone weakness increases the risk of a broken bone. Until a broken bone occurs, there are typically no symptoms. Osteoporosis affects more than 75 million people in the United States, Europe and Japan. The diagnosis of osteoporosis is primarily determined by measuring bone mineral density using dual-energy X-ray absorptiometry, but for men under 50 years of age, premenopausal women should not be made on the basis of densitometric criteria alone. Bone biomarkers are a useful tool in detecting osteoporotic. A two-step dual-label time-resolved fluorescence immunoassay (TRFIA) was developed for the simultaneous detection of serum C-terminal telopeptide (β-CTX) and amino-terminal propeptide (P1NP) of Type I procollagen in a single run. The performance of this assay was first evaluated using clinical serum samples, and then compared with commercialized kits. The sensitivity of this assay for β-CTX was 1 ng/L (dynamic range, 0-1000 ng/L), and the sensitivity for P1NP detection was 1 μg/L (dynamic range, 1-1000 μg/L). High correlation coefficients (R) were obtained between the present dual-label TRFIA and commercially available kits (R = 0.99 for β-CTX and P1NP). The present dual-label TRFIA has high sensitivity, specificity and accuracy in clinical sample analysis. It is a good alternative to the single-label diagnostic methods. [ABSTRACT FROM AUTHOR]

Environmental pressures vary by geographic location and will lead to differentiation in life history traits according to which maximize fitness. Life history theory predicts that harsh environments are likely to select for larger egg or offspring size, and for a stronger trade-off between offspring size and number. To test this prediction, we compared life history traits among 11 plateau brown frog (Rana kukunoris) populations at different altitudes. We found that females with a concomitant increase in body size produce larger eggs and more offspring in warm environments than females in cold environments do. Moreover, females from two natural populations produced offspring of different sizes between years. The decreasing resource allocation to current offspring size and number may increase survival and future fecundity in harsh environments. Thus, there may be a trade-off between mortality and fecundity in different environments. In addition to body size, we suggest that temperature plays an important role in shaping maternal investment variation in R. kukunoris across geographical gradients. [ABSTRACT FROM AUTHOR]

The formation of microemulsions in the presence of cyclohexane, Triton X-100,n-butanol, water, and task-special ionic liquid (TSIL) (1-2-aminoethyl-3-butylimidazolium tetrafluoroborate) was studied at 25°C. The phase behavior of this ternary system was investigated. Three subregions (namely, water-in-oil phase, bicontinuous phase, and oil-in-water phase) were identified in the single-phase region by dynamic light scattering (DLS) technique and electrical conductivity measurement. Microstructures of microemulsions with different water contents have been predicted by using dissipative particle dynamics (DPD) simulation. It was found that the DPD simulations successfully reproduce the experimental results in the article. The location of TSIL in the microemulsions was predicted by DPD simulation further. The result indicates that TSIL is more easy to locate in the surfactant and cosurfactant layer and has amphiphilicity, which provides us new insights into the potential applications of TSIL-based microemulsions in separation and new nano-scale material preparation because of the interaction of TSIL with some special components at the interface of oil and water. [ABSTRACT FROM AUTHOR]

The objective of this study is to explore the self-healing process or diffusion of the asphalt materials on aggregates through the experiments and molecular dynamics (MD) simulations. The asphalt mastic samples were prepared with binders and fine aggregates. The microscale dynamic X-ray computed tomography was conducted to capture the self-diffusion process of the binder in the asphalt mastic controlled at 353.15 K using Advanced Photon Source beamline 2-BM. The Mean Square Displacements were analyzed to describe the self-healing behaviors of binders by an MD method. The results of tests and MD simulations show that the molecules of the asphalt model on the nanoscale at high temperatures move faster those at low temperatures. The asphalt molecules move forward to aggregate layer and expand contact area to reduce the system energy. [ABSTRACT FROM AUTHOR]

Drug-related laboratory test interference or drug/laboratory test interactions (DLTI) are a major source of laboratory errors. DLTI is of concern with regard to both the clinical diagnosis and the monitoring of patients. Although there have been numerous reports about specific drugs that interfere with laboratory tests, there has not been a recent review on the topic. We herein provide a review of the known DLTI of US FDA-approved drugs based on a systematic search of DailyMed, a website containing the labels of US FDA-approved drugs. The labels for all human single-ingredient prescription drugs included in the database (1368) were searched using stemmed keywords and were manually reviewed for their relevance to DLTI. A total of 134 labels were positive, which indicated that the drug interferes with at least one clinical laboratory test. Antibacterial agents, psychotropic drugs and contrast media are the classes of drugs most likely to lead to DLTI. Urine was the clinical sample most frequently affected by DLTI. The FDA drug label is a source of information for studies of DLTI, although information is still lacking for most drugs, and additional improvements are needed for many of the existing records. Medical professionals, clinicians and laboratory staff should keep these possible interactions in mind when interpreting the results of laboratory tests, and should ensure that they obtain a complete and accurate record of all drugs being used by patients in order to anticipate potential DLTI. The development of a reporting system to address potential DLTI is warranted. [ABSTRACT FROM AUTHOR]

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Nano-emulsions containing task-special ionic liquid ([NH2ebim][PF6]) were prepared by spontaneous emulsification. The stability of nano-emulsions was investigated by analysis of droplet size. The microstructure of the mixed solvent including the Triton X-100, n-butanol, and [NH2ebim][PF6] was demonstrated based on macular dynamic simulation. The results indicate that nano-emulsions are relatively stable to the droplet growth at static storage, but unstable under high centrifugal force. Simulation results from the macular dynamic calculation show that [NH2ebim][PF6] locates in the hydrophobic layer of Triton X-100 and n-butanol, which is available for enhancing CO2mass transfer in an absorption process. Nano-emulsions were used as the absorbent to absorb CO2in absorption experiments, and the absorption rates were investigated. The results show that nano-emulsion containing [NH2ebim][PF6] can enhance CO2absorption rate compared to the system that pure water was used as the absorbent. The reason is attributed to the reversible chemical reaction between [NH2ebim][PF6] and CO2on the interface of oil and water, which decreases the concentration of CO2in the bulk so as to increase the mass transfer driving force between gas and liquid. Therefore, the chemical reaction on the interface of oil and water promotes the absorption process. [ABSTRACT FROM PUBLISHER]

Rhus punjabensis var. sinica belongs to the family Anacardiaceae in the order Sapindales. In this study, we first reported the complete chloroplast genome sequence of R. punjabensis var. sinica. The cp genome was sequenced on Illumina Hiseq 2000 platform. The sequence was found to be 159,617 bp in length with 37.9% GC contents, including a large single-copy region of 87,694 bp, a small single-copy region of 18,971 bp, and a pair of inverted repeats of 26,476 bp. The chloroplast genome of R. punjabensis var. sinica contains 133 genes, including 86 protein-coding genes, 8 rRNA genes, and 2 pseudogenes identified by CPGAVAS2 and BLAST search, and 37 tRNA genes annotated by tRNAscan-SE. Maximum-likelihood (ML) phylogenetic analysis showed that R. punjabensis var. sinica was sister to Rhus potaninii. [ABSTRACT FROM AUTHOR]

The complete chloroplast genome sequence of Iris tectorum Maximowicz, assembled with Illumina NovaSeq 6000 system platform sequencing data, was reported. The total length of the chloroplast genome of I. tectorum is 153,253 bp and its GC content is 37.89%. The complete chloroplast genome has four distinct parts a large single copy region (82,833 bp), a small single copy region (18,562 bp), and a pair of inverted repeats (25,929 bp). The chloroplast genome includes 86 protein-coding genes, 8 rRNAs and 38 tRNAs genes. A phylogenetic tree showed that I. tectorum is close to Iris missouriensis. [ABSTRACT FROM AUTHOR]

Objective: To provide a basis for evaluating the prognosis of small left heart system development in fetuses, we analyzed its related factors.Methods: The fetal echocardiogram was performed in 3859 pregnant women, and then small left heart system development was identified in 69 fetuses. The data of prenatal and postnatal echocardiograms, postnatal cardiac surgical treatment, chromosome and autopsy after induced labor were analyzed in the 69 fetuses.Results: Except 1320 cases losing follow-up, 2539 cases had complete data. Among the 2539 cases, small left heart system development was identified in 69 fetuses. Of the 69 fetuses, 12 had hypoplastic left heart syndrome, 20 premature closure of foramen ovale, 13 total anomalous pulmonary venous drainage, 2 common pulmonary vein lumen atresia, 21 aortic coarctation or interruption and 1 right pulmonary hypoplasia. Among the 69 fetuses, chromosome abnormality was found in 7.Conclusion: There are many etiological factors causing small left heart system development. The prognosis is poor in the fetuses with hypoplastic left heart syndrome, common pulmonary vein lumen atresia, pulmonary hypoplasia, other malformations or/and chromosome abnormality. Fetal echocardiography combined with chromosome examination can provide important bases for making diagnosis and evaluating the prognosis regarding small left heart system development. [ABSTRACT FROM AUTHOR]

The prognostic impact of portal vein thrombosis (PVT) in liver cirrhosis remains controversial among studies, primarily because the risk stratification of PVT is often lacking. A definition of clinically significant PVT should be proposed and actively improved. Moreover, the risk factors for the development of PVT in liver cirrhosis should be fully recognized to screen and identify high-risk patients. Currently, well-recognized risk factors include a reduced portal vein flow velocity, a worse liver function, splenectomy, liver transplantation, and factor V Leiden and prothrombin G20210A mutations. Novel risk factors include an increased flow volume of portosystemic collateral vessel, thrombopoietin receptor agnonists, and non-selective beta-blockers. In contrast to the traditional perspectives, the abnormalities of procoagulant and anticoagulant factors may not contribute to the development of PVT in liver cirrhosis. Further studies should explore the role of other risk factors, such as antiphospholipid antibodies, methylenetetrahydrofolate reductase C677T gene mutation, hyperhomocysteinemia, and myeloproliferative neoplasms. [ABSTRACT FROM PUBLISHER]

Multivariate meta-regression models are commonly used in settings where the response variable is naturally multidimensional. Such settings are common in cardiovascular and diabetes studies where the goal is to study cholesterol levels once a certain medication is given. In this setting, the natural multivariate endpoint is low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and triglycerides (TG) (LDL-C, HDL-C, TG). In this article, we examine study level (aggregate) multivariate meta-data from 26 Merck sponsored double-blind, randomized, active, or placebo-controlled clinical trials on adult patients with primary hypercholesterolemia. Our goal is to develop a methodology for carrying out Bayesian inference for multivariate meta-regression models with study level data when the within-study sample covariance matrixSfor the multivariate response data is partially observed. Specifically, the proposed methodology is based on postulating a multivariate random effects regression model with an unknown within-study covariance matrix Σ in which we treat the within-study sample correlations as missing data, the standard deviations of the within-study sample covariance matrixSare assumed observed, and given Σ,Sfollows a Wishart distribution. Thus, we treat the off-diagonal elements ofSas missing data, and these missing elements are sampled from the appropriate full conditional distribution in a Markov chain Monte Carlo (MCMC) sampling scheme via a novel transformation based on partial correlations. We further propose several structures (models) for Σ, which allow for borrowing strength across different treatment arms and trials. The proposed methodology is assessed using simulated as well as real data, and the results are shown to be quite promising. Supplementary materials for this article are available online. [ABSTRACT FROM AUTHOR]

This article investigates the method that captures and fixes CO2using ionic liquid-emulsion liquid membrane (IL-ELM). IL-ELM was prepared and used to absorb CO2. Experimental results indicate that IL-ELM enhances the rate of CO2mass transfer and increases the amount of CO2absorption. Meanwhile, CaCO3fine particles are synthesized in the internal phase of IL-ELM due to the presence of Ca(OH)2solvent. Physicochemical coupling facilitating mass transfer mechanism is proposed in order to explain the enhancement mechanism by IL-ELM. The effect of operating parameters on the absorption rate was investigated, and results agree well with the prediction proposed by physicochemical coupling facilitating mass transfer mechanism. [ABSTRACT FROM AUTHOR]

Southeast China, an important part of the circum–Pacific magmatic–metallogenetic belt, was characterized by late Mesozoic extensive magmatism and related metallogenesis. It is now generally accepted that this magmatism was related to subduction of the Palaeo-Pacific plate, and a series of tectonic models such as normal subduction, shallow subduction, and flat-slab subduction have been suggested. Here we propose a new tectonic model involving repeated slab advance–retreat of the Palaeo-Pacific plate on the basis of new geochronological and geochemical data of Late Triassic to Early Jurassic mafic rocks and Early Jurassic A-type granites in southern Jiangxi and western Fujian provinces. The results indicate that Late Triassic (ca. 228 Ma) mafic rocks are shoshonitic, formed in a post-collisional regime of the Tethyan tectonic domain. Early Jurassic (ca. 197–191 Ma) mafic rocks are sodic, emplaced in a continental arc setting coupled with the subduction of the Palaeo-Pacific plate. Early Jurassic (ca. 189 Ma) granites, occurring as a NNE-trending belt, belong to the A2group and formed in an extension setting caused by slab break-off. There are an other four A-type granite belts in southeast China, i.e. the Late Triassic, Late Jurassic, Early Cretaceous, and Late Cretaceous A-type granite belts, respectively. Late Triassic (229–221 Ma) A-type granites occur as an ENE-trending belt and were coincident with the Late Triassic mafic magmatism. Late Jurassic (163–153 Ma), Early Cretaceous (136–124 Ma), and Late Cretaceous (101–91 Ma) A-type granite belts, together with the Early Jurassic (189 Ma) A-type granite belt, are all NNE-trending, parallel to the present coastline. The Late Jurassic belt is located further inland, on the west side of the Early Jurassic belt. The Early Cretaceous belt almost overlaps the Early Jurassic belt and the Late Cretaceous belt is located at the coastal area of southeast China. Integrating these observations, we propose a repeated slab-advance–retreat model for the late Mesozoic magmatic evolution of southeast China. Palaeo-Pacific plate subduction underneath southeast China initiated in the Late Triassic Rhaetian and reached southern Jiangxi by ca. 197 Ma, followed by slab rollback during 197–191 Ma and by slab break-off at ca. 189 Ma. Then slab advance was reestablished with the northwestward subduction approaching southern Hunan at ca. 178 Ma. From ca. 174 Ma, slab rollback reinitiated and gradually migrated from inland to the coastal area. This repeated slab-advance–retreat model is helpful to further understand the geodynamic mechanism of the late Mesozoic tectono-magmatism and related metallogenesis of southeast China. [ABSTRACT FROM AUTHOR]

Melicope pteleifolia, an important medicinal and horticultural plant, has antipyretic, anti-inflammatory, and analgesic effects. Here, the complete chloroplast genome of M. pteleifolia was sequenced and its phylogenetic relationship was investigated. The complete chloroplast genome of M. pteleifolia was 159,014 bp in size, including a pair of inverted repeat regions (IR, 27,640 bp), a large single copy region (LSC, 85,124 bp), and a small single copy region (SSC, 18,610 bp). The GC content of the chloroplast genome was 38.3%. A total of 133 genes were annotated, including 88 protein-coding genes, 8 rRNA genes, and 37 tRNA genes. Phylogenetic analysis revealed that M. pteleifolia clusters together with species of Toddalia, Zanthoxylum, Tetradium, Phellodendron, and Casimiroa. [ABSTRACT FROM AUTHOR]

We reported the complete chloroplast genome sequences of Rhus potaninii which was characterized by de novo assembly with Illumina sequencing data. The size of R. potaninii complete chloroplast genome is 159,620 bp in length and includes a large single copy region of 87,722 bp, a small single copy region of 18,948 bp, and a pair of inverted repeats of 26,475 bp. Its GC content is 37.9%. A total of 133 genes were predicted, including 86 protein-coding genes, 8 rRNA genes, 37 tRNA genes, and 2 pseudogenes. Maximum-likelihood (ML) phylogenetic tree indicates that R. potaninii is sister to R. chinensis. [ABSTRACT FROM AUTHOR]

The complete chloroplast sequence ofDendrobium officinale, an endangered and economically important traditional Chinese medicine, was reported and characterized. The genome size is 152,018 bp, with 37.5% GC content. A pair of inverted repeats (IRs) of 26,284 bp are separated by a large single-copy region (LSC, 84,944 bp) and a small single-copy region (SSC, 14,506 bp). The complete cp DNA contains 83 protein-coding genes, 39 tRNA genes and 8 rRNA genes. Fourteen genes contained one or two introns. [ABSTRACT FROM AUTHOR]