1. The HLA-C*05 family allele - C*05:142.
- Author
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Rowlands, J., Climer, T., Harvey, C., Williams, L., and Darke, C.
- Subjects
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HLA histocompatibility antigens , *EXONS (Genetics) , *AMINO acids , *BLOOD donors , *IMMUNE serums - Abstract
The sequencing of exons 2-7 of a likely new HLA-C*05 allele identified the second example of HLA-C*05:142, in a male UK European, within a few months of the first example being found in Germany. C*05:142 differs from C*05:01:01:01 by a single base (395G>C) in exon 3 resulting in an amino acid substitution of R108P. Comprehensive serological HLA-Cw5 typing, using 19 antisera, indicated that C*05:142 encodes a 'normal' Cw5 specificity. Failure to identify the involvement of position 108 in published HLA-C epitopes supported this assertion. The likely HLA class I C*05:142-bearing haplotype is A*02:01~C*05:142~B*44:02. This new allele has a maximum frequency of 0.00001, in 34,743 sequenced-based typed subjects, contrasting with that of C*05:01 (allele frequency 0.10441), in our local, largely UK European, blood donors. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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