1. DNA interaction and photodynamic antitumor activity of transition metal mono-hydroxyl corrole.
- Author
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Sun YM, Akram W, Cheng F, Liu ZY, Liao YH, Ye Y, and Liu HY
- Subjects
- Antineoplastic Agents chemistry, Apoptosis, Humans, Hydroxyl Radical, Membrane Potential, Mitochondrial, Mitochondria drug effects, Mitochondria metabolism, Neoplasms pathology, Photochemotherapy, Tumor Cells, Cultured, Antineoplastic Agents pharmacology, Copper chemistry, DNA metabolism, Ferric Compounds chemistry, Manganese chemistry, Neoplasms therapy, Porphyrins chemistry
- Abstract
A series of iron(III), manganese(III) and copper(III) mono-hydroxyl corrole complexes had been prepared and well characterized by UV-vis,
1 H NMR,19 F NMR and HR-MS. These metallocorroles may bind to CT-DNA through external binding mode. Metallocorrole Fe-2c exhibited significant phototoxicity and low toxicity toward A549 tumor cells. While manganese (III) and copper (III) corroles showed hypotoxicity to A549, MCF-7 and HepG-2 tumor cells, whether under dark or illumination conditions. All tested metallocorroles exhibited non-toxicity to human normal cells (GES-1) with or without irradiation at 625 nm. Cell cycle analysis indicated that metallocorrole Fe-2c arrested the cell cycle at G2/M phase and increased the Sub-G1 phase in A549 cell lines. It was mainly localized at mitochondria and could significantly reduce mitochondrial membrane potential after photodynamic treatment, which would further induce tumor cell apoptosis., (Copyright © 2019 Elsevier Inc. All rights reserved.)- Published
- 2019
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