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17 results on '"Adah, Dickson"'

5. Plasmodium immunotherapy combined with gemcitabine has a synergistic inhibitory effect on tumor growth and metastasis in murine Lewis lung cancer models

Author

Chen, Xiao, primary, Tao, Zhu, additional, Liang, Yun, additional, Ma, Meng, additional, Adah, Dickson, additional, Ding, Wenting, additional, Chen, Lili, additional, Li, Xiaofen, additional, Dai, Linglin, additional, Fanuel, Songwe, additional, Zhao, Siting, additional, Hu, Wen, additional, Wu, Donghai, additional, Duan, Ziyuan, additional, Zhou, Fang, additional, Qin, Li, additional, Chen, Xiaoping, additional, and Yang, Zhaoqing, additional

Published
2023
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8. Additional file 2 of Subsequent malaria enhances virus-specific T cell immunity in SIV-infected Chinese rhesus macaques

Author

Liu, Guangjie, Qin, Li, Li, Youjia, Zhao, Siting, Shugay, Mikhail, Yan, Yongxiang, Ye, Yijian, Chen, Yue, Huang, Cuizhu, Bayaer, Nashun, Adah, Dickson, Zhang, Hui, Su, Zhong, and Chen, Xiaoping

Abstract

Additional file 1. Fig S1: Cell numbers and ratios of peripheral CD4+ and CD8+ T cells of animals. (A) CD4+ and (B) CD8+ T cells in peripheral blood. (C) CD4+/CD8+ T cell ratio in peripheral blood. (D) Frequency of CD4+CCR5+ cells (among total CD4+ T lymphocytes). The data were from all the animals that survived at the assay time point. Blue and red arrows indicate the times of Pc inoculation and chloroquine treatment, respectively. Fig S2: Gating strategies for CD4+ T cell subpopulations. Flow cytometry gating strategies for naïve, effector memory (TEM) and central memory (TCM) CD4+ T cell subpopulations in PBMCs. SSC, side scatter height; FSC, forward scatter height. Fig S3: The serum anti-SIV antibody titer for the three SIV-infected groups. Fig S4: T-cell repertoire diversity in malaria- and SIV-infected monkeys. (A) SIV infection significantly reduced the repertoire diversity. Change in Chao1 total diversity estimate and Shannon index (entropy of clonotype frequency distributions) with respect to control (0 weeks of SIV infection). (B) Malaria infection increased the Shannon index but not the total repertoire diversity. (C) Increase in the Shannon index was a result of attenuation of dominant clonal expansions. The decrease in the relative frequency of expanded clonotypes occurred at acute malaria infection (week 3 post malaria introduction). Fig S5: Malaria-induced changes in repertoire structure and frequency of SIV-specific clonotypes. (A) T-cell repertoires at acute malaria infection were characterized by decreased hydrophobicity (GRAVY index) and increased NDN size, suggesting an increase in polyreactive clonotype frequency. *: P < 0.05, two-tailed paired t-test. (B) SIV-specific clonotypes identified by tetramer sorting (Price et al. data) were characterized by a decreased GRAVY index compared to the pooled repertoire of control samples. P-values were computed using the Kolmogorov-Smirnov test.

Published
2022
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9. Prodrug‐Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer

Author

Liu, Quan, primary, Xie, Zhongjian, additional, Qiu, Meng, additional, Shim, Inseob, additional, Yang, Yunlong, additional, Xie, Sisi, additional, Yang, Qinhe, additional, Wang, Dou, additional, Chen, Shiyou, additional, Fan, Taojian, additional, Ding, Bo, additional, Guo, Ziheng, additional, Adah, Dickson, additional, Yao, Xinhuang, additional, Zhang, Yuhua, additional, Wu, Hong, additional, Wu, Zongze, additional, Wei, Chaoying, additional, Wang, Hongzhong, additional, Kim, Hyeong Seok, additional, Zou, Qingshuang, additional, Yan, Qiaoting, additional, Cai, Zhen, additional, Kim, Jong Seung, additional, Liu, Li‐Ping, additional, Zhang, Han, additional, and Cao, Yihai, additional

Published
2020
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12. 4-Aryl Pyrrolidines as Novel Orally Efficacious Antimalarial Agents. Part 2: 2-Aryl-N-(4-arylpyrrolidin-3-yl)acetamides

Author

Meyers, Marvin J., primary, Liu, Jianguang, additional, Liu, Zhijun, additional, Ma, Hongwei, additional, Dai, Linglin, additional, Adah, Dickson, additional, Zhao, Siting, additional, Li, Xiaofen, additional, Liu, Xiaorong, additional, Lu, Yongzhi, additional, Huang, Yanhui, additional, Tu, Zhengchao, additional, Chen, Xiaoping, additional, and Tortorella, Micky D., additional

Published
2019
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17. The complement receptor C5aR2 promotes protein kinase R expression and contributes to NLRP3 inflammasome activation and HMGB1 release from macrophages.

Author

Songlin Yu, Dan Wang, Lingmin Huang, Yening Zhang, Ruiheng Luo, Adah, Dickson, Yiting Tang, Kai Zhao, and Ben Lu

Subjects
*COMPLEMENT receptors, *PROTEIN kinases, *MITOGEN-activated protein kinases, *TYPE 2 diabetes
Abstract

The NLR family pyrin domain-containing 3 (NLRP3) inflammasome is a multimeric protein complex that mediates maturation of the cytokines IL-1β and IL-18 as well as release of the proinflammatory protein high-mobility group box 1 (HMGB1) and contributes to several inflammatory diseases, including sepsis, gout, and type 2 diabetes. In this context, the well-studied active complement fragment C5a and its receptor C5aR1 or C5aR2 orchestrate the inflammatory responses in many diseases. Although a C5a-C5aR interaction in NLRP3-associated diseases has been suggested, little is known about the details of C5a-C5aR cross-talk with the NLRP3 inflammasome in macrophages. In this study, using mice and murine macrophages and cytokines, immunoblotting, siRNA, and quantitative real-time PCR assays, we demonstrate that C5aR2 deficiency restricts activation of the NLRP3 inflammasome and release of HMGB1 both in vitro and in vivo. Mechanistically, we found that C5aR2 promotes NLRP3 activation by amplifying dsRNA-dependent PKR expression, which is an important NLRP3-activating factor. We also observed that elevation of PKR expression because of the C5a-C5aR2 interaction depends on the mitogen-activated protein kinase/extracellular signal-regulated kinase kinase pathway and type I IFN signaling. In conclusion, these findings reveal that C5aR2 contributes to NLRP3 inflammasome activation and HMGB1 release from macrophages. [ABSTRACT FROM AUTHOR]

Published
2019
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