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15 results on '"Wiebe, Sheldon"'

2. MRI overestimates articular cartilage thickness and volume compared to synchrotron radiation phase-contrast imaging

Author

Bairagi, Suranjan, primary, Abdollahifar, Mohammad-Amin, additional, Atake, Oghenevwogaga J., additional, Dust, William, additional, Wiebe, Sheldon, additional, Belev, George, additional, Chapman, L. Dean, additional, Webb, M. Adam, additional, Zhu, Ning, additional, Cooper, David M. L., additional, and Eames, B. Frank, additional

Published
2023
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6. Two children with extra-nodalMycobacterium aviumcomplex infection

Author

Markland, Ali, primary, Tan, Ben, additional, Adamko, Darryl, additional, Diener, Tania, additional, Levett, Paul N, additional, Wiebe, Sheldon, additional, Wang, Hui, additional, Podberezin, Mark, additional, Saczek, Krysztof, additional, Milbrandt, Kris, additional, Essalah, Abdulhafid, additional, Quan, William, additional, and Deneer, Harry, additional

Published
2020
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7. Two children with extra-nodal Mycobacterium avium complex infection.

Author

Markland, Ali, Tan, Ben, Adamko, Darryl, Diener, Tania, Levett, Paul N, Wiebe, Sheldon, Wang, Hui, Podberezin, Mark, Saczek, Krysztof, Milbrandt, Kris, Essalah, Abdulhafid, Quan, William, and Deneer, Harry

Subjects
MYCOBACTERIAL disease diagnosis, URINARY tract infection diagnosis, URINARY tract infections, MYCOBACTERIUM avium, RESPIRATORY infections, BATHS, MYCOBACTERIAL diseases, CHILDREN
Abstract

Mycobacterium avium complex (MAC) is usually considered an opportunistic organism, which infects immunocompromised children or those with structural airway abnormalities. We present two cases of MAC infection affecting immune competent children, likely from hot tubs with primary involvement of pulmonary and urinary systems. These cases highlight the importance of asking about hot tub use in immune competent children with suspected or confirmed MAC infections. [ABSTRACT FROM AUTHOR]

Published
2021
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8. Integrated genome and transcriptome sequencing identifies a noncoding mutation in the genome replication factor DONSON as the cause of microcephaly-micromelia syndrome

Author

Evrony, Gilad D., primary, Cordero, Dwight R., additional, Shen, Jun, additional, Partlow, Jennifer N., additional, Yu, Timothy W., additional, Rodin, Rachel E., additional, Hill, R. Sean, additional, Coulter, Michael E., additional, Lam, Anh-Thu N., additional, Jayaraman, Divya, additional, Gerrelli, Dianne, additional, Diaz, Diana G., additional, Santos, Chloe, additional, Morrison, Victoria, additional, Galli, Antonella, additional, Tschulena, Ulrich, additional, Wiemann, Stefan, additional, Martel, M. Jocelyne, additional, Spooner, Betty, additional, Ryu, Steven C., additional, Elhosary, Princess C., additional, Richardson, Jillian M., additional, Tierney, Danielle, additional, Robinson, Christopher A., additional, Chibbar, Rajni, additional, Diudea, Dana, additional, Folkerth, Rebecca, additional, Wiebe, Sheldon, additional, Barkovich, A. James, additional, Mochida, Ganeshwaran H., additional, Irvine, James, additional, Lemire, Edmond G., additional, Blakley, Patricia, additional, and Walsh, Christopher A., additional

Published
2017
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9. Two children with extra-nodal Mycobacterium aviumcomplex infection.

Author

Markland, Ali, Tan, Ben, Adamko, Darryl, Diener, Tania, Levett, Paul N, Wiebe, Sheldon, Wang, Hui, Podberezin, Mark, Saczek, Krysztof, Milbrandt, Kris, Essalah, Abdulhafid, Quan, William, and Deneer, Harry

Abstract

Mycobacterium aviumcomplex (MAC) is usually considered an opportunistic organism, which infects immunocompromised children or those with structural airway abnormalities. We present two cases of MAC infection affecting immune competent children, likely from hot tubs with primary involvement of pulmonary and urinary systems. These cases highlight the importance of asking about hot tub use in immune competent children with suspected or confirmed MAC infections.

Published
2021
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11. Integrated genome and transcriptome sequencing identifies a noncoding mutation in the genome replication factor DONSONas the cause of microcephaly-micromelia syndrome

Author

Evrony, Gilad D., Cordero, Dwight R., Shen, Jun, Partlow, Jennifer N., Yu, Timothy W., Rodin, Rachel E., Hill, R. Sean, Coulter, Michael E., Lam, Anh-Thu N., Jayaraman, Divya, Gerrelli, Dianne, Diaz, Diana G., Santos, Chloe, Morrison, Victoria, Galli, Antonella, Tschulena, Ulrich, Wiemann, Stefan, Martel, M. Jocelyne, Spooner, Betty, Ryu, Steven C., Elhosary, Princess C., Richardson, Jillian M., Tierney, Danielle, Robinson, Christopher A., Chibbar, Rajni, Diudea, Dana, Folkerth, Rebecca, Wiebe, Sheldon, Barkovich, A. James, Mochida, Ganeshwaran H., Irvine, James, Lemire, Edmond G., Blakley, Patricia, and Walsh, Christopher A.

Abstract

While next-generation sequencing has accelerated the discovery of human disease genes, progress has been largely limited to the “low hanging fruit” of mutations with obvious exonic coding or canonical splice site impact. In contrast, the lack of high-throughput, unbiased approaches for functional assessment of most noncoding variants has bottlenecked gene discovery. We report the integration of transcriptome sequencing (RNA-seq), which surveys all mRNAs to reveal functional impacts of variants at the transcription level, into the gene discovery framework for a unique human disease, microcephaly-micromelia syndrome (MMS). MMS is an autosomal recessive condition described thus far in only a single First Nations population and causes intrauterine growth restriction, severe microcephaly, craniofacial anomalies, skeletal dysplasia, and neonatal lethality. Linkage analysis of affected families, including a very large pedigree, identified a single locus on Chromosome 21 linked to the disease (LOD > 9). Comprehensive genome sequencing did not reveal any pathogenic coding or canonical splicing mutations within the linkage region but identified several nonconserved noncoding variants. RNA-seq analysis detected aberrant splicing in DONSONdue to one of these noncoding variants, showing a causative role for DONSONdisruption in MMS. We show that DONSONis expressed in progenitor cells of embryonic human brain and other proliferating tissues, is co-expressed with components of the DNA replication machinery, and that Donsonis essential for early embryonic development in mice as well, suggesting an essential conserved role for DONSON in the cell cycle. Our results demonstrate the utility of integrating transcriptomics into the study of human genetic disease when DNA sequencing alone is not sufficient to reveal the underlying pathogenic mutation.

Published
2017
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12. Learning Rigid Image Registration - Utilizing Convolutional Neural Networks for Medical Image Registration

Author

Jan Paul Siebert, K.A. Goatman, J.M. Sloan, Wiebe, Sheldon, Gamboa, Hugo, Fred, Ana, and Bermúdez i Badia, Sergi

Subjects
Modality (human–computer interaction), Computer science, business.industry, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Image registration, Convolutional neural network, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Task (computing), Consistency (database systems), 0302 clinical medicine, Outlier, Medical imaging, Segmentation, Computer vision, Artificial intelligence, business, 030217 neurology & neurosurgery
Abstract

Many traditional computer vision tasks, such as segmentation, have seen large step-changes in accuracy and/or speed with the application of Convolutional Neural Networks (CNNs). Image registration, the alignment of two or more images to a common space, is a fundamental step in many medical imaging workflows. In this paper we investigate whether these techniques can also bring tangible benefits to the registration task. We describe and evaluate the use of convolutional neural networks (CNNs) for both mono- and multi- modality registration and compare their performance to more traditional schemes, namely multi-scale, iterative registration. This paper also investigates incorporating inverse consistency of the learned spatial transformations to impose additional constraints on the network during training and investigate any benefit in accuracy during detection. The approaches are validated with a series of artificial mono-modal registration tasks utilizing T1-weighted MR brain i mages from the Open Access Series of Imaging Studies (OASIS) study and IXI brain development dataset and a series of real multi-modality registration tasks using T1-weighted and T2-weighted MR brain images from the 2015 Ischemia Stroke Lesion segmentation (ISLES) challenge. The results demonstrate that CNNs give excellent performance for both mono- and multi- modality head and neck registration compared to the baseline method with significantly fewer outliers and lower mean errors.

Published
2018

13. Antenatal diagnosis of bronchopulmonary sequestration: A case report and review of the literature.

Author

Dhanju G, Goubran A, Kirkpatrick I, Wiebe S, and Fogel J

Abstract

Congenital lung malformations are a constellation of pathologies that can be diagnosed antenatally by ultrasound and fetal MRI. Ultrasound is considered the modality of choice for a routine assessment of second-trimester scans worldwide. Bronchopulmonary sequestration (BPS) and congenital pulmonary airway malformation (CPAM) are the 2 most common echogenic chest masses discovered incidentally during routine ultrasound scans in the second trimester. This paper describes BPS and differentiates it from CPAM sonographically in utero. An extensive literature search involving antenatal ultrasound is undertaken to review the most up-to-date understanding of the BPS. Furthermore, a case study at our institution and the literature review will help better describe the salient features of BPS. A 41-year-old female G3P1 visits our department for a routine second-trimester ultrasound. An echogenic lesion with a cystic component is visualized in this scan. Based on the grayscale and color imaging, this complex echogenic lesion was reported as CPAM and was referred to fetal assessment for confirmation. The fetal assessment diagnosed the lesion as BPS because of the pathognomonic feeding vessel from the thoracic aorta. Regardless of the congenital lung mass, any large mass compromising fetal well-being is an indication for intervention. The prognosis of BPS in the absence of fetal hydrops is excellent. A robust collaboration among radiologists, obstetricians, and pediatricians is required for the best outcome for the pregnancy and the neonate., (© 2023 The Authors.)

Published
2023
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14. Two children with extra-nodal Mycobacterium avium complex infection.

Author

Markland A, Tan B, Adamko D, Diener T, Levett PN, Wiebe S, Wang H, Podberezin M, Saczek K, Milbrandt K, Essalah A, Quan W, and Deneer H

Abstract

Mycobacterium avium complex (MAC) is usually considered an opportunistic organism, which infects immunocompromised children or those with structural airway abnormalities. We present two cases of MAC infection affecting immune competent children, likely from hot tubs with primary involvement of pulmonary and urinary systems. These cases highlight the importance of asking about hot tub use in immune competent children with suspected or confirmed MAC infections., (© The Author(s) 2020. Published by Oxford University Press on behalf of the Canadian Paediatric Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2020
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15. Diffraction-Enhanced Computed Tomographic Imaging of Growing Piglet Joints by Using a Synchrotron Light Source.

Author

Rhoades GW, Belev GS, Chapman LD, Wiebe SP, Cooper DM, Wong AT, and Rosenberg AM

Subjects
Age Factors, Animals, Animals, Newborn, Cartilage, Articular diagnostic imaging, Cartilage, Articular growth & development, Male, Predictive Value of Tests, Radiographic Image Interpretation, Computer-Assisted, Swine, Arthrography instrumentation, Arthrography methods, Joints growth & development, Synchrotrons, Tomography, X-Ray Computed
Abstract

The objective of this project was to develop and test a new technology for imaging growing joints by means of diffraction-enhanced imaging (DEI) combined with CT and using a synchrotron radiation source. DEI-CT images of an explanted 4-wk-old piglet stifle joint were acquired by using a 40-keV beam. The series of scanned slices was later 'stitched' together, forming a 3D dataset. High-resolution DEI-CT images demonstrated fine detail within all joint structures and tissues. Striking detail of vasculature traversing between bone and cartilage, a characteristic of growing but not mature joints, was demonstrated. This report documents for the first time that DEI combined with CT and a synchrotron radiation source can generate more detailed images of intact, growing joints than can currently available conventional imaging modalities.

Published
2015

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