1. Association of Dengue Virus and Leptospira Co-Infections with Malaria Severity.
- Author
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Mandage, Rajendra, Kaur, Charandeep, Pramanik, Atreyi, Kumar, Vinod, Kodan, Parul, Singh, Adarsh, Saha, Sounak, Pandey, Shivam, Wig, Naveet, Pandey, Ravindra Mohan, Soneja, Manish, and Acharya, Pragyan
- Subjects
MALARIA diagnosis ,RESEARCH ,DENGUE ,FLAVIVIRUSES ,GRAM-negative bacteria ,RESEARCH methodology ,MEDICAL cooperation ,EVALUATION research ,MALARIA ,COMPARATIVE studies ,MIXED infections ,DISEASE complications - Abstract
Plasmodium infections are co-endemic with infections caused by other agents of acute febrile illnesses, such as dengue virus (DENV), chikungunya virus, Leptospira spp., and Orientia tsutsugamushi. However, co-infections may influence disease severity, treatment outcomes, and development of drug resistance. When we analyzed cases of acute febrile illness at the All India Institute of Medical Sciences, New Delhi, India, from July 2017 through September 2018, we found that most patients with malaria harbored co-infections (Plasmodium mixed species and other pathogens). DENV was the most common malaria co-infection (44% of total infections). DENV serotype 4 was associated with mild malaria, and Leptospira was associated with severe malaria. We also found the presence of P. knowlesi in our study population. Therefore, in areas with a large number of severe malaria cases, diagnostic screening for all 4 DENV serotypes, Leptospira, and all Plasmodium species should be performed. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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