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Key Clinical Message: If you encounter an unexplained case of bone marrow edema in a young patient, consider the possibility of osteoid osteoma (OO). Even in the presence of a nidus near vital structures, RFA can safely be used to treat OO. [ABSTRACT FROM AUTHOR]

Key Clinical Message: Adenoid cystic carcinoma (ACC) is an uncommon malignancy of head and neck. Although the cornerstone of treatment is surgery, concurrent chemoradiotherapy (CRT) might be used as an effective treatment for unresectable tumors. Herein we report a case of massive ACC of base of tongue with durable complete response to definitive CRT. Adenoid cystic carcinoma (ACC) is a rare tumor accounting for 1% of all head and neck cancers. The best treatment option is complete surgical resection with or without adjuvant radiotherapy. When surgical resection is not feasible, definitive radiotherapy with or without concurrent chemotherapy can be considered. Herein we report a non‐smoker 72‐year‐old woman presented with throat discomfort and sensation of a lump. Evaluation revealed an unresectable adenoid cystic carcinoma of the base of tongue in whom complete clinical response was achieved after definitive concurrent chemoradiation. Although the cornerstone of treatment is complete surgical resection, this case report indicates that concurrent chemoradiotherapy might result in complete clinical response and could be used as a definitive treatment in selected ACC tumors. [ABSTRACT FROM AUTHOR]

Irrigation and crop management practices play a crucial role in ecology and agrohydrology and can have significant environmental and socio-economic impacts. The important decision factors include soil moisture and water salinity, particularly in arid and semi-arid regions. In this study, the effects of these two factors on maize are quantitatively measured. To collect data, design of experiments is utilized at a greenhouse in a research center. The dataset consists of eighteen variables, including sixteen qualitative, quantitative, and morphological maize characteristics, as well as two decision variables, i.e., water depletion and salinity. This endeavor aims to promote the use of multi-objective decision-making techniques in the water management context to improve agricultural practices in regions facing water scarcity. To ensure appropriate data analysis, besides data visualization, multivariate and repeated measures analysis of variance are employed. Subsequently, a repeated measures model is used to fit statistical models and construct the corresponding responses. Furthermore, to determine the optimal levels of soil moisture and water salinity, which are often in conflict with each other, the problem is approached within a multi-objective framework. The weighted p-norm method is employed to incorporate management priorities in the decision-making process and facilitate tradeoffs between these two factors. Policy implications based on the findings are provided, offering valuable insights for improving irrigation and crop management practices. Detailed guidelines are provided on how to effectively analyze a problem, construct a model, and verify its assumptions. [ABSTRACT FROM AUTHOR]

Magnetic resonance imaging (MRI) is a non-invasive highly sensitive tool for diagnosing chondromalacia patellae in the early stages. Many studies have evaluated patellar and trochlear morphology with different radiologic indices. We aimed to assess the discriminative power of tibial, patellar, and femoral indices in MRI for chondromalacia patellae.

This paper presents an improved switched‐inductor quasi‐Z‐source inverter with a higher boost factor than similar inverters, which integrates a switched‐capacitor and a three‐winding switched‐coupled inductor into a conventional quasi Z‐source inverter (q‐ZSI). The proposed inverter is called a switched‐capacitor trans quasi Z‐source inverter (SCT‐q‐ZSI). In this topology, the input current is continuous, and a high voltage gain is reachable with lowduty cycles (D). In this structure, capacitors are used instead of the side diodes of the switched‐inductor quasi Z‐source inverter. The proposed converter has a low inrush current at the startup which might damage the converter components. The performance of the proposed inverter is investigated at different operating modes and the voltage and current equations of all elements are calculated. The analysis, derivation of boost factor, capacitor voltages, and components, of the proposed inverter, are carried out and are compared with similar inverters. Finally, analytical, simulation, and experimental results are also presented to validate its advantages. [ABSTRACT FROM AUTHOR]

Cholangiocarcinoma, malignant tumor of epithelial cells of bile ducts has poor overall survival and prognosis. We report a case of non-resectable cholangiocarcinoma with a 57-month survival after incomplete R2 surgical margin resection of the tumor. A 52-year old man with generalized itching, jaundice, brownish urine, mild abdominal pain and weight loss of 8 kg in last two months presented. Imaging and surgical workups showed hilar cholangiocarcinoma (Klatskin tumor). Along with incomplete R2 margin resection we performed stent embedding and post-operative adjuvant chemotherapy. Based on current literature data there is no superiority of adjuvant chemotherapy after complete R0 resection compared to incomplete R2 resection. However, it seems that partial resection along with stent embedding and applied adjuvant chemotherapy in cases of locally advanced non-resectable cholangiocarcinoma may increase survival rate.

Agnathia is one of the first pharyngeal arch deformities referred to as mandibular abnormality. This case report aimed to describe an unusual form of agnathia-otocephaly in a Mehraban ewelamb accompanied by other malformations. The scrutiny of the lamb's face indicated a chain of abnormalities in the head region. Lack of mandible, lips, rima oris, oral cavity, tongue, and teeth were recognized. Eyes and ear lobes were normal, but the base of the pinnae met each other ventral to the atlantooccipital joint and formed a single external acoustic meatus there. The nostrils were normally formed, but the philtrum was not formed due to the lack of lips, especially the upper lip. The hyoid apparatus was normally developed. The laryngopharynx had no connection with the nasopharynx and dead end. Also, the nasal cavities ended blindly because of rinopharyngeal aplasia and no choanal foramen. So, the abnormal pharyngeal region caused a non-functional respiratory system followed by death. [ABSTRACT FROM AUTHOR]

Introduction: The present study aimed to investigate the interaction of the common lncRNA-miRNA-mRNA network involved in signaling pathways in different stages of prostate cancer (PCa) by using bioinformatics and experimental methods. Methods: Seventy subjects included sixty PCa patients in Local, Locally Advanced, Biochemical Relapse, Metastatic, and Benign stages, and ten healthy subjects were entered into the current study. The mRNAs with significant expression differences were first found using the GEO database. The candidate hub genes were then identified by analyzing Cytohubba and MCODE software. Cytoscape, GO Term, and KEGG software determined hub genes and critical pathways. The expression of candidate lncRNAs, miRNAs, and mRNAs was then assessed using Real-Time PCR and ELISA techniques. Results: 4 lncRNAs, 5 miRNAs, and 15 common target genes were detected in PCa patients compared with the healthy group. Unlike the tumor suppressors, the expression levels of common onco-lncRNAs, oncomiRNAs, and oncogenes showed a considerable increase in patients with advanced stages; Biochemical Relapse and Metastatic, in comparison to the primary stages; Local and Locally Advanced. Additionally, their expression levels significantly increased with a higher Gleason score than a lower one. Conclusion: Identifying a common lncRNA-miRNA-mRNA network associated with prostate cancer may be clinically valuable as potential predictive biomarkers. They can also serve as novel therapeutic targets for PCa patients. [ABSTRACT FROM AUTHOR]

Comparative studies, in addition to showing the overlap between culture and literature, can lead to the identification of national literature as much as possible and reveal the position of each work in comparison with its international examples; therefore, such studies can play a significant role in the globalization of literature and identifying the strengths and weaknesses of local works. One of the approaches that can be used for the comparative study of two works is the narratological approach. In this approach, the narrative elements of two works are measured together and the similarities and differences are determined. Various theories have been proposed in the field of narratology. One of the most important theories in this regard belongs to the French theorist Gerard Genet (1930). He considers the "story" or the main plot of the story to be one of the aspects of the narrative and considers it to be the real sequence of events One of the approaches that can be used for the comparative study of two works is the narratological approach. In this approach, the narrative elements of two works are measured together and the similarities and differences are determined. Various theories have been proposed in the field of narratology. One of the most important theories in this regard belongs to the French theorist Gerard Genet (1930). He considers the "story" or the main plot of the story to be one of the aspects of the narrative and considers it to be the real sequence of events. In this research, a comparative comparison of one of the narrative elements (grammatical Tense) in two novels, "Don Quixote" and "Dayi Jan Napoleon", has been done. Tense is one of the elements that gives identity to narrative and story and is defined by three components of order, continuity and frequency. [ABSTRACT FROM AUTHOR]

Muscular stomach or gizzard is one of the most important parts of gastrointestinal tract in birds for mechanical and chemical digestion and can vary depending on the bird's eating habits. In the present study, the morphology of muscular stomach in common kestrel, steppe eagle, golden eagle and imperial eagle has been investigated and compared. Materials & Methods: In this study, common kestrel (n=4), steppe eagle (n=5), golden eagle (n=4) and imperial eagle (n=6) which died because of broken leg and wing, sent to the faculty of veterinary science at Bu-Ali Sina University of Hamadan. The gizzard samples were fixed in 10% formalin buffer solution and the histological process was carried. Finally, H&E, Masson's trichrome, Orcein and PAS staining were utilized. Results: The most important difference between the stomach of steppe, golden, and imperial eagles and common kestrel was the lack of keratinous layer in the surface of stomach in eagles. The histological structure of stomach in imperial eagle was more similar to that of steppe eagle. The differences of the stomach of imperial eagle were due to the presence of a thick muscle layer in several different rows with different directions in comparison with steppe and golden eagles. Conclusions: It can be concluded that, the structure of muscular stomach in common kestrel was similar to gizzard, while the stomach in three species of eagles did not have a keratinous layer. [ABSTRACT FROM AUTHOR]

Background and Objectives: The non-surgical treatment outcome of gastroesophageal junction (GEJ) adenocarcinoma remains to be defined. We aimed to assess the outcomes of definitive chemoradiation (CRT) of GEJ tumors. Methods: This retrospective cohort study was entirely carried out in the radiation oncology ward of Cancer Institute of Iran. We included patients with adenocarcinoma histology whose tumors had involved the gastro-esophageal junction and underwent chemoradiotherapy without surgery. In the final analysis, we evaluated 50 patients with non-metastatic adenocarcinoma of GEJ (Siewert's type I and II) from 2008 to 2017. The primary outcome was overall survival; secondary outcomes were progression-free survival and local and distal metastasis. Results: The reasons for not undergoing surgery in order of frequency from highest to lowest were patient refusal or medical unfitness for surgery, tumor unresectability or progress at the time of operation and incident metastasis in pre-op restaging, and. The 1-year, 2-year, and 3-year overall survival rates were 53%, 26%, and 12%, respectively. The 1-year, 2-year, and 3-year progression-free survival rates were 44%, 18%, and 10%, respectively. In the multivariate analysis, the only independent predictor of survival was a distant failure (P=0.031). Conclusion: Although the outcomes of non-surgical treatments are disappointing in GEJ adenocarcinomas, a few patients may experience long-term survival using definitive CRT. This option should be discussed with all patients who are not candidates for surgery. [ABSTRACT FROM AUTHOR]

Background: One of the most important fundamental issues in mental health is patients' satisfaction with the beauty of their teeth and their compatibility with complete dentures. Therefore, this study investigated the role of early maladaptive schemas and body image in the level of satisfaction with complete dentures among patients referred to the dental clinic of Islamic Azad University of Tabriz, Iran, in 2021-2022. Methods: The research was a descriptive correlational study. This study's statistical population included all candidates for complete dentures referring to the dental clinic of Islamic Azad University of Tabriz in 2021-22, from among which, 168 people were selected through convenience sampling method. The research tools included the Young Schema Questionnaire-Short Form (YSQ-SF) (1988), Body Image Concern Inventory (BICI) Littleton et al. (2005), and Dental Satisfaction Questionnaire (DSQ) by Davies and Ware (1982). The collected data were analyzed using multiple regression tests in SPSS software. Results: The results showed a relationship between the components of early maladaptive schemas [failure (B = -0.225), defectiveness/shame (B = -0.279), social isolation/alienation (B = 0.278), abandonment/instability (B = 0.331), subjugation (B = -0.264), and dependence/incompetence (B = 0.246)] and the level of satisfaction with complete dentures among the patients (P < 0.05). The results also showed a significant relationship between the components of body image and the level of satisfaction with complete dentures (P < 0.05). Conclusion: It can be concluded that early maladaptive schemas and body image playa role in the satisfaction level of patients referred to the dental clinic of Islamic Azad University of Tabriz. [ABSTRACT FROM AUTHOR]

Most histotechnical methods and preparation of tissue sections were invented and used in the 18th and 19th centuries. Due to the colorless nature of most cells and tissues in the body, tissue staining methods were used from the beginning to differentiate cells and tissues. Materials & Methods: According to sources and reports in this field, the time required for each hematoxylin-eosin staining period is approximately 80 minutes. In the present study, a method of hematoxylin-eosin staining is reported that reduces the time required for staining by maintaining the quality of sections and staining from 80 minutes to less than 40 minutes. Also, considering the existing problems regarding the cost of histochemistry and immunohistochemistry kits, the Low amount of kits and the problems that exist in the drip staining method of this type of staining, the present report tries to present three creative methods in this regard. These methods increase the quality of the prepared slides, in addition to reducing consumables. Optimization of tissue staining steps can reduce expenses spent and increase the quality of tissue sections. [ABSTRACT FROM AUTHOR]

The proventriculus is one of the most important parts of digestive tract in birds for mechanical and chemical digestion and can vary depending on the bird's eating habits. In the present study, the morphological and histological structure of proventriculus in common kestrel, steppe eagle, golden eagle and imperial eagle have been investigated and compared. In this study, Proventriculus of common kestrel (n=4), steppe eagle (n=5), golden eagle (n=4) and imperial eagle (n=6) were collected and fixed in 10% formalin buffer solution and the histological process were carried. Finally, H&E, Masson's trichrome, Orcein and PAS stainings were utilized. Histologically, slight differences were observed between the proventriculus of common kestrel and steppe eagle. Notable differences included a continuous and relatively thicker layer of mucosal muscle in the steppe eagle's proventriculus, and the distinct simple columnar epithelium of the submucosal glands type II ducts. The only notable structural difference in golden eagle was the presence of relatively dense connective tissue of lamina propria and one to three layers of continuous smooth muscle in its structure. The histological structure of imperial eagle's proventriculus had two differences with its structure in common kestrel. Firstly, the lamina propria was composed of relatively dense connective tissue and secondly, the muscle layer was relatively thinner than other species examined in this study, while the serosa layer had a considerable thickness. It can be concluded that the structure of proventriculus was similar in three species of eagles and common kestrel, and the main significant difference was related to the layers of mucosal muscle. [ABSTRACT FROM AUTHOR]