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Your search keyword '"Nam, Kung-Woo"' showing total 13 results
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13 results on '"Nam, Kung-Woo"'

2. In vitro activity of (-)-deoxypergularinine, on its own and in combination with anti-tubercular drugs, against resistant strains of Mycobacterium tuberculosis

Author

Nam, Kung-Woo, Jang, Woong Sik, Jyoti, Anirban, Kim, Sukyung, Lee, Byung-Eui, and Song, Ho-Yeon

Subjects
Antitubercular agents -- Dosage and administration -- Complications and side effects, Drug resistance in microorganisms -- Drug therapy -- Research, Tuberculosis -- Drug therapy -- Research, Biological sciences, Health, Science and technology
Abstract

ABSTRACT Background: The increasing incidence of multidrug-resistant tuberculosis (MDR-TB) infections has created a need for new effective drugs that also target extensively drug-resistant tuberculosis (XDR-TB) and/or augment the activities of [...]

Published
2016
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6. Aster yomena suppresses LPS-induced cyclooxygenase-2 and inducible nitric oxide synthase expression

Author

Shim Hyun-Jin, Youn Hyung-Sun, Kim Ji-Soo, Ahn Sang-Il, Hwang Kyung-A, Kim Ah-Yeon, Nam Kung-Woo, and Shin Hyeon-Myeong

Subjects
0301 basic medicine, INSECT BITES, biology, business.industry, Immunology, Pharmacology, Proinflammatory cytokine, Nitric oxide synthase, 03 medical and health sciences, IκBα, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Biochemistry, chemistry, 030220 oncology & carcinogenesis, biology.protein, Medicine, Cyclooxygenase, Nitrite, business, Agronomy and Crop Science, Gene, Aster yomena, Food Science
Abstract

Inflammation is a pathological process that is known to be involved in numerous diseases. Microbial infection or tissue injury activates inflammatory responses, resulting in the induction of proinflammatory proteins including cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Aster yomena is used in traditional Korean remedies to treat cough, asthma, and insect bites. Here, we investigated the effects of A. yomena extract (EAY) on the expression of COX-2 and iNOS induced by LPS. EAY inhibited NF-κB activation and IκBα degradation induced by LPS. EAY suppressed LPS-induced COX-2 and iNOS expression which are the target genes regulated through NF-κB activation in macrophages. EAY also suppressed LPS-induced nitrite production. These results suggest that EAY has the potential to be developed as a potent anti-inflammatory drug.

Published
2016

13. Aster yomena suppresses LPS-induced cyclooxygenase-2 and inducible nitric oxide synthase expression.

Author

Kim, Ji-Soo, Kim, Ah-Yeon, Shin, Hyeon-Myeong, Ahn, Sang-Il, Shim, Hyun-Jin, Nam, Kung-Woo, Hwang, Kyung-A, and Youn, Hyung-Sun

Subjects
INFLAMMATION treatment, CYCLOOXYGENASE 2, NITRIC-oxide synthases, PROTEIN expression, ASTERACEAE
Abstract

Inflammation is a pathological process that is known to be involved in numerous diseases. Microbial infection or tissue injury activates inflammatory responses, resulting in the induction of proinflammatory proteins including cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).Aster yomenais used in traditional Korean remedies to treat cough, asthma, and insect bites. Here, we investigated the effects ofA. yomenaextract (EAY) on the expression of COX-2 and iNOS induced by LPS. EAY inhibited NF-κB activation and IκBα degradation induced by LPS. EAY suppressed LPS-induced COX-2 and iNOS expression which are the target genes regulated through NF-κB activation in macrophages. EAY also suppressed LPS-induced nitrite production. These results suggest that EAY has the potential to be developed as a potent anti-inflammatory drug. [ABSTRACT FROM AUTHOR]

Published
2017
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