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Laryngeal squamous cell carcinoma (LSCC) is a malignant tumor with a high probability of metastasis. The tumor microenvironment (TME) plays a critical role in cancer metastasis. To gain insights into the TME of LSCC, we conducted single-cell RNA-seq (scRNA-seq) on samples collected from LSCC patients with or without lymphatic metastasis. The stem and immune cell signatures in LSCC suggest their roles in tumor invasion and metastasis. Infiltration of a large number of regulatory T cells, dysplastic plasma cells, and macrophages that are at the early development stage in the cancerous tissue indicates an immunosuppressive state. Abundant neutrophils detected at the cancer margins reflect the inflammatory microenvironment. In addition to dynamic ligand-receptor interactions between the stromal and myeloid cells, the enhanced autophagy in endothelial cells and fibroblasts implies a role in nutrient supply. Taken together, the comprehensive atlas of LSCC obtained allowed us to identify a complex yet unique TME of LSCC, which may help identify potential diagnostic biomarkers and therapeutic targets for LSCC.

Objective With urban regional cultural inheritance as the background, the expression and application of Wu Region cultural elements in the public space of Suzhou metro are discussed, and the application value and strategies are summarized. Method Based on the connotation of Wu Region culture, such as inclusiveness, worship of literature and education, flexibility and talent, the extraction method of Wu Region cultural elements is put forward through three ways: typical extraction, abstraction rule and cultural symbol reconstruction. The case analysis is used to analyze the application of Wu Region cultural elements in Suzhou Metro entrances and exits, public art within station and inside carriage compartment from the aspects of design description, material technology, construction technology and technical requirements. The concrete ways of constructing the unique cultural landscape of Suzhou metro with architectural elements, garden elements, cultural character, catering culture, religious beliefs, language culture, opera culture and other aspects of Wu Region culture are introduced in detail. Result & Conclusion Based on the rules of Wu Region cultural elements extraction, to realize the translation and transmission of traditional culture in Suzhou Metro public space by way of establishing Wu Region cultural symbol design system, endowing Wu Region cultural symbol functions and cultural semantics, and applying modern design means will promote significance for inheriting the urban context, shaping the urban spirit in the new era, and enhancing the soft power of urban culture.

In recent years, the development of artificial intelligence technology and theory has been rapid, and the application in language science has been gradually comprehensive and diversified, especially the accuracy rate of artificial intelligence for Chinese language is up to 90%. In the era of artificial intelligence, the effect of different structures and parameters of arithmetic models on Chinese language recognition varies greatly. Language science is an important research area for realizing machine-human communication, and accurate comprehension of the meaning of linguistic expressions is the key to realize communication. In this paper, we construct a speech system that is different from the traditional stable time series for the irreplaceable characteristics of artificial intelligence technology to improve Chinese language ability. A dynamic Bayesian network (DBN) is used for modeling and analysis, and a DBN construction method is investigated to import a hidden Markov model in a speech recognition system to reveal the interactions between nodes within multiple time slices. The accuracy of dynamic Bayesian networks in Chinese dialect inference algorithms is demonstrated using Matlab simulations to characterize the reliability of speech features using a speech spectrogram. It proves that artificial intelligence technology and Chinese language science are complementary and mutually reinforcing, showing a good and rapid development trend.

Dynamic disaster formation and triggering are closely related to the mechanical behavior of the regional stress field. The regional local stress field is continuously adjusted and changed under the effect of coal mining disturbance. In order to study the precursor response of regional stress field change to dynamic disasters, we used the analytical methods of variational modal decomposition and Hilbert transform to perform time-frequency analysis on the data collected from the Baodian coal mine and to identify and extract the intrinsic modal function (IMF) components reflecting the abnormal dynamic changes in the borehole strain data. The results show that the borehole strain observation data can effectively record the small changes inside the rock mass related to the mining disturbance. After decomposition and transformation, the abnormal fluctuation characteristics of IMF components appear two days before the dynamic pressure event, which is characterized by a “sudden jump” from the stage of stable deformation to the stage of rapid change, “shock” in the stage of rapid deformation change and “drop” in the stage of instability. According to the three-stage theory of seismic deformation, the normal starting time of deformation before the occurrence of dynamic disasters and the “sudden jump-shock-fall” are used as the precursor criteria for the occurrence of coal mine dynamic disasters. Based on the accurate observation of the regional stress field by borehole strainmeter, a criterion method applied to the warning of coal mine power hazards is constructed, which can provide a reference for the safe and efficient recovery of working faces under similar mining environments in coal mines.

Energy storage is a new, flexibly adjusting resource with prospects for broad application in power systems with high proportions of renewable energy integration. However, energy storage systems have spare capacity under stable working conditions and may be idle for some periods. These actions are primarily selected for peak shaving and valley filling, frequency regulation, and voltage regulation as the only control target; thus, energy storage cannot be used effectively, which weakens the effect of energy storage on grid support. To improve the utilization rate and economic benefits of the energy storage system and enhance the support performance of energy storage for the safe operation of the power grid, this article proposes a switching control strategy for an energy storage system based on multi-layer logic judgment to maximize energy storage benefits and ensure safe and stable power grid operation. First, this study analyzed the potential multi-ancillary service operation requirements of the energy storage system, combined with the auxiliary compensation benefits of the energy storage power station. Using this information, the study proposed a comprehensive index that considers the economy of the energy storage system and the stable operation of the power grid to support the evaluation needs of energy storage control. Based on this, the study then pre-set multi-layer judgment logic for the operation control of the energy storage system. A multi-objective judgment and smooth switching strategy for the coordinated operation of the energy storage system was proposed based on the typical operating conditions of the energy storage system participating in the grid peak shaving and valley filling, frequency regulation, and voltage regulation. This switching control method effectively utilized the idle capacity of the energy storage system and improved the energy storage system’s support effect on the power grid. Through the improved energy storage control model based on MATLAB/Simulink, this study also verified the effectiveness of the proposed smooth switching strategy of the energy storage system.

Introduction: Abdominal pain is a common complaint in the emergency department. Point-of-care ultrasound (POCUS) is a rapid modality to evaluate for the etiology.Case Report: A teenage male presented with symptoms concerning for appendicitis. POCUS revealed a non-peristalsing, non-compressible, tubular structure containing an echogenic stone. This was determined to be a ureteral stone within a dilated ureter, not appendicitis.Conclusion: We propose a syndromic sonographic approach to right lower quadrant pain (RLQ) that includes the gallbladder, right kidney, bladder, and right adnexa, in addition to RLQ landmarks. This case emphasizes the value of such an approach to avoid diagnostic error.