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Your search keyword '"Wei, Yun-Peng"' showing total 17 results
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17 results on '"Wei, Yun-Peng"'

9. Calcium Sensing Receptor Variants Increase Pulmonary Hypertension Susceptibility

Author

Liu, Bingxun, primary, Wei, Yun-Peng, additional, Fan, Xiaohang, additional, Hu, Xiaoyi, additional, Chen, Zeshuai, additional, Liu, Xiaoyuan, additional, Xu, Yan, additional, Wang, Lu, additional, Wang, Tao, additional, Ruiz, Matthieu, additional, Dupuis, Jocelyn, additional, Yuan, Ping, additional, Liu, Jinming, additional, Huang, Songling, additional, Zhu, Liping, additional, Jing, Zhi-Cheng, additional, and Hu, Qinghua, additional

Published
2022
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14. Effects of Carbopol® 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Author

Zheng, Yin, Ouyang, Wu-Qing, Wei, Yun-Peng, Syed, Shahid Faraz, Hao, Chao-Shuang, Wang, Bo-Zhen, and Shang, Yan-Hong

Subjects
Male, integumentary system, topical drug delivery, Administration, Topical, Skin Absorption, Guinea Pigs, nanoemulsion, Administration, Cutaneous, transdermal drug delivery, Permeability, Nanomedicine, Acrylates, Animals, nanoemulsion gel, Emulsions, Gels, Carbopol 934 proportion, Original Research, Skin
Abstract

Nanoemulsions (NEs) are used as transdermal drug delivery systems for systematic therapeutic purposes. We hypothesized that the skin permeation profile of an NE could be modulated by incorporating it into a hydrogel containing differing proportions of thickening agent. The objectives of this study were as follows: 1) to determine the stability and skin irritability of NE gels (NGs) containing 1%, 2%, and 3% (w/w) Carbopol® 934 (CP934) (termed NG1, NG2, and NG3, respectively); 2) to compare the skin permeation profiles and drug deposition patterns of the NGs; and 3) to visualize the drug delivery routes of the NGs. Terbinafine and citral were incorporated into the NGs as model drugs. Ex vivo skin permeation tests indicated that the percutaneous flux rates of terbinafine decreased in the order NE (215 μg/cm2) > NG1 (213 μg/cm2) > NG2 (123 μg/cm2) > NG3 (74.3 μg/cm2). The flux rates of citral decreased in the order NE (1,026 μg/cm2) > NG1 (1,021 μg/cm2) > NG2 (541 μg/cm2) > NG3 (353 μg/cm2). The NGs accumulated greater amounts of the drugs in the stratum corneum and less in the epidermis/dermis than did the NE (P

Published
2016

17. Effects of Carbopol ® 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study.

Author

Zheng Y, Ouyang WQ, Wei YP, Syed SF, Hao CS, Wang BZ, and Shang YH

Subjects
Administration, Cutaneous, Administration, Topical, Animals, Emulsions, Gels, Guinea Pigs, Male, Permeability, Skin cytology, Skin Absorption, Acrylates chemistry, Acrylates metabolism, Nanomedicine, Skin metabolism
Abstract

Nanoemulsions (NEs) are used as transdermal drug delivery systems for systematic therapeutic purposes. We hypothesized that the skin permeation profile of an NE could be modulated by incorporating it into a hydrogel containing differing proportions of thickening agent. The objectives of this study were as follows: 1) to determine the stability and skin irritability of NE gels (NGs) containing 1%, 2%, and 3% (w/w) Carbopol ® 934 (CP934) (termed NG1, NG2, and NG3, respectively); 2) to compare the skin permeation profiles and drug deposition patterns of the NGs; and 3) to visualize the drug delivery routes of the NGs. Terbinafine and citral were incorporated into the NGs as model drugs. Ex vivo skin permeation tests indicated that the percutaneous flux rates of terbinafine decreased in the order NE (215 μg/cm 2 ) > NG1 (213 μg/cm 2 ) > NG2 (123 μg/cm 2 ) > NG3 (74.3 μg/cm 2 ). The flux rates of citral decreased in the order NE (1,026 μg/cm 2 ) > NG1 (1,021 μg/cm 2 ) > NG2 (541 μg/cm 2 ) > NG3 (353 μg/cm 2 ). The NGs accumulated greater amounts of the drugs in the stratum corneum and less in the epidermis/dermis than did the NE ( P <0.05) over a period of 12 h. Laser scanning confocal microscopy indicated that the NGs altered the main drug delivery routes from skin appendages to intercellular paths. Histological images suggested that perturbations to the skin structure, specifically the size of the epidermal intercellular spaces and the separation distance of dermal collagen bundles, could be significantly minimized by increasing the proportion of CP934. These results suggest that adjustments of the CP934 proportions can be used to modulate the skin permeation profiles of NGs for specific therapeutic purposes., Competing Interests: The authors report no conflicts of interest in this work.

Published
2016
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