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Primary nephrotic syndrome （PNS） is one of the most common types of glomerular diseases in children， which is also an important cause of chronic renal insufficiency in children in China. Due to autoimmune disorders and the use of hormones and immunosuppressants， children with PNS are more prone to respiratory tract infections than normal counterparts. The effect and mechanism of different pathogens upon pediatric PNS also differ. In this article， the effect of viruses， bacteria， mycoplasma and other pathogens on PNS pediatric was reviewed， aiming to provide theoretical basis for improving clinical efficacy and prognosis of PNS children.

The insight of the activity phase and reaction mechanism is vital for developing high-performance ammonia synthesis electrocatalysts. In this study, the origin of the electronic-dependent activity for the model Cu2O catalyst toward ammonia electrosynthesis with nitrate was probed. The modulation of the electronic state and oxygen vacancy content of Cu2O was realized by doping with halogen elements (Cl, Br, I). The electrocatalytic experiments showed that the activity of the ammonia production depends strongly on the electronic states in Cu2O. With increased electronic state defects in Cu2O, the ammonia synthesis performance increased first and then decreased. The Cu2O/Br with electronic defects in the middle showed the highest ammonia yield of 11.4 g h−1 g−1 at −1.0 V (vs. RHE), indicating that the pattern of change in optimal ammonia activity is consistent with the phenomenon of volcano curves in reaction chemistry. This work highlights a promising route for designing NO3−RR to NH3 catalysts. [ABSTRACT FROM AUTHOR]

We consider an important feature of satellite synchronization in the practical scenario of using unmanned vehicles (UVs) carried by trucks for “last-meter” delivery and introduce the truck and UV routing problem with time windows (TUVRP-TW) for optimizing the routes of a homogeneous fleet of truck-UV combinations. A UV that has been dispatched from its truck must be picked up by the same truck or must return by itself to the depot. Customers with time windows are classified into two types: truck-UV customers (TUCs) and UV customers (UCs). The TUCs where trucks dispatch or pick up the carried UVs are regarded as satellites. Fleet coordination and satellite synchronization are essential for modelling the TUVRP-TW. We classify satellite synchronization into inner-satellite synchronization and intersatellite synchronization. The inner-satellite synchronization generally considered in the literature focuses on synchronization operations at the same satellite. Intersatellite synchronization, which focuses on synchronization operations at various satellites, allows UVs to not return to the dispatched locations, if necessary. In the mixed-integer linear programming model of the TUVRP-TW, both binary variables for identifying the appointed satellites and continuous variables for time continuity constraints are introduced to ensure the interaction between truck routes and UV routes. A hybrid algorithm based on a greedy randomized adaptive search procedure (GRASP) and a variable neighborhood search (VNS) is provided. Based on generated instances and benchmark instances, computational experiments are conducted to evaluate the performance of the intersatellite synchronization, the performance of the developed formulation, and the applicability of the hybrid algorithm., Author(s): Hongqi Li (corresponding author) [1]; Jiamin Zhao [1]; Zhuopeng Zhan [1] 1. Introduction Through developing and adopting new technologies to improve operations, logistics enterprises can offer high-quality express services [...]

Raffinose synthetase (RS) is a key enzyme in the process of raffinose (Raf) synthesis and is involved in plant development and stress responses through regulating Raf content. As a sweetener, Raf makes an important contribution to the sweet taste of white tea. However, studies on the identification, analysis and transcriptional regulation of CsRSs (Camellia sinensis RS genes) are still lacking. In this study, nine CsRSs were identified from the tea plant (Camellia sinensis) genome database. The CsRSs were classified into five groups in the phylogenetic tree. Expression level analysis showed that the CsRSs varied in different parts of the tea plant. Transcriptome data showed that CsRSs could respond to persistent drought and cold acclimation. Except for CsRS5 and CsRS9, the expression pattern of all CsRSs increased at 12 h and decreased at 30 h during the withering process of white tea, consistent with the change trend of the Raf content. Furthermore, combining yeast one-hybrid assays with expression analysis, we found that CsDBB could potentially regulate the expression of CsRS8. Our results provide a new perspective for further research into the characterization of CsRS genes and the formation of the white tea flavour. [ABSTRACT FROM AUTHOR]