7,220 results
Search Results
2. One procedure-one report: the Re-Imagine Cytopathology Task Force position paper on small tissue biopsy triage in anatomic pathology.
- Author
-
Ly A, Balassanian R, Alperstein S, Donnelly A, McGrath C, Sohani AR, Stelow EB, Thrall MJ, Zhang ML, and Pitman MB
- Subjects
- Humans, Biopsy, Large-Core Needle, Pathologists, United States, Biopsy, Triage
- Abstract
Introduction: Endoscopic biopsy procedures increasingly generate multiple tissue samples from multiple sites, and frequently retrieve concurrent cytologic specimens and small core needle biopsies. There is currently lack of consensus in subspecialized practices as to whether cytopathologists or surgical pathologists should review such samples, and whether the pathology findings should be reported together or separately., Materials and Methods: In December 2021, the American Society of Cytopathology convened the Re-Imagine Cytopathology Task Force to examine various workflows that would facilitate unified pathology reporting of concurrently obtained biopsies and improve clinical care., Results and Conclusions: This position paper summarizes the key points and highlights the advantages, challenges, and resources available to support the implementation of such workflows that result in "one procedure-one report"., (Copyright © 2023 American Society of Cytopathology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
3. PCR performance for the diagnosis of cutaneous leishmaniasis caused by Leishmania viannia complex using biopsy samples, compared with exudate samples from skin lesions on filter paper.
- Author
-
Apaza-Castillo YG, Aguilar-Ancori EG, Quispe-Flórez MM, Ramírez-Soto MC, and Pacheco-Venero RL
- Subjects
- DNA, Protozoan, Exudates and Transudates, Humans, Leishmania classification, Peru, Sensitivity and Specificity, Skin pathology, Biopsy, Leishmania genetics, Leishmania isolation & purification, Leishmaniasis, Cutaneous diagnosis, Polymerase Chain Reaction methods, Skin Ulcer parasitology
- Abstract
Background: Cutaneous leishmaniasis (CL) is generally diagnosed by molecular methods, including PCR, using biopsy samples, skin scrapings and clinical exudates. In this study, we assessed the PCR performance for diagnosis of CL using skin of biopsy samples vs PCR of skin lesion exudate samples on filter paper and compared the diagnostic concordance of PCR using both sampling methods., Methods: We assessed the PCR performance using 80 skin biopsy samples and 80 filter paper samples containing exudates from skin lesions obtained from 74 patients with clinical suspicion of CL in Cusco, Peru., Results: : PCR using skin biopsy samples had superior diagnostic accuracy compared with filter paper PCR (62.5% [50/80] vs 38.7% [31/80], respectively; p˂0.005) and the diagnostic concordance between both sampling methods was 'moderate' (kappa coefficient=0.50, 95% CI 0.98 to 1.0)., Conclusions: PCR using biopsy samples remains the standard for diagnosis of CL., (© The Author(s) 2020. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.)
- Published
- 2020
- Full Text
- View/download PDF
4. ECCO Position Paper: Harmonization of the Approach to Ulcerative Colitis Histopathology.
- Author
-
Magro F, Doherty G, Peyrin-Biroulet L, Svrcek M, Borralho P, Walsh A, Carneiro F, Rosini F, de Hertogh G, Biedermann L, Pouillon L, Scharl M, Tripathi M, Danese S, Villanacci V, and Feakins R
- Subjects
- Colonoscopy methods, Consensus, Europe, Humans, Patient Acuity, Prognosis, Reference Standards, Remission Induction methods, Treatment Outcome, Biopsy methods, Biopsy standards, Colitis, Ulcerative drug therapy, Colitis, Ulcerative pathology, Histological Techniques methods, Histological Techniques standards, Intestinal Mucosa diagnostic imaging, Intestinal Mucosa pathology
- Abstract
Currently, the main targets of drug therapy for ulcerative colitis [UC] are endoscopic and clinical remission. However, there is active discussion about the additional advantages of including histological remission as a target. Accumulating evidence indicates that microscopic activity persists in endoscopically quiescent UC, that histological changes may lag behind clinical remission after treatment, and that absence of histological activity predicts lower rates of relapse, hospitalization, surgery and subsequent neoplasia. Obtaining useful information from mucosal biopsies in this setting depends on accurate and consistent evaluation of histological features. However, there is no standardization of biopsy procedures, histological sample processing technique or histological scoring systems, and there is no agreement on the definitions of histological remission, response or activity. Accordingly, a consensus expert panel convened by the European Crohn's and Colitis Organisation [ECCO] reviewed the literature and agreed a number of position statements regarding harmonization of UC histopathology. The objective was to provide evidence-based guidance for the standardization and harmonization of procedures, definitions and scoring systems for histology in UC, and to reach expert consensus where possible. We propose the absence of intraepithelial neutrophils, erosion and ulceration as a minimum requirement for the definition of histological remission. For randomized control trials we recommend the use of the Robarts histopathology index [RHI] or the Nancy index [NI]. For observational studies or in clinical practice we recommend the use of the NI. To predict the risk of future neoplasia in UC, cumulative histological scores over time are more useful than single scores., (© The Author(s) 2020. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2020
- Full Text
- View/download PDF
5. An Update of the American Urological Association White Paper on the Prevention and Treatment of the More Common Complications Related to Prostate Biopsy.
- Author
-
Liss MA, Ehdaie B, Loeb S, Meng MV, Raman JD, Spears V, and Stroup SP
- Subjects
- Humans, Male, Postoperative Complications epidemiology, Biopsy adverse effects, Postoperative Complications diagnosis, Postoperative Complications prevention & control, Prostate pathology
- Abstract
Purpose: In this white paper update we identify and discuss the prevalence and prevention of common complications of prostate needle biopsy., Materials and Methods: A literature review was performed on prostate biopsy complications via queries of PubMed and EMBASE
® databases for prostate biopsy complications from January 1, 2010 until June 1, 2015. We focused on infection, bleeding, urinary retention, needle tract seeding and erectile dysfunction. A total of 346 articles were identified for full text review and 119 are included in the final data synthesis., Results: Infection is the most common complication of prostate biopsy with fluoroquinolone resistant Escherichia coli having a prominent role. Reported rates of infectious complications range from 0.1% to 7.0%, and sepsis rates range from 0.3% to 3.1% depending on antibiotic prophylaxis regimens. Mild, self-limiting and transient bleeding is also a common complication. Other complications are extremely rare., Conclusions: This white paper provides a concise reference document for the more common prostate biopsy complications and prevention strategies. Risk assessment should be performed for all patients to identify known risk factors for harboring fluoroquinolone resistance. If infection incidence increases check the local antibiogram, current equipment and cleaning practices, and consider alternate approaches to antibiotic prevention such as needle cleaning, risk basked augmentation, rectal culture with targeted prophylaxis and transperineal biopsy. If infection occurs, actively re-situate the patient and start empiric intravenous treatment with carbapenems, amikacin or second and third generation cephalosporins., (Copyright © 2017 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.)- Published
- 2017
- Full Text
- View/download PDF
6. SIIV position paper: clinical approach to vulval diseases. Need for quality standards.
- Author
-
CARRIERO, Carmine, BELFiORE, Pina, CORAZZA, Monica, CRIPPA, Stefano, DE MAGNIS, Angelina, MARIANI, Luciano, MICHELETTI, Leonardo, PRETI, Eleonora P., PRETI, Mario, RADICI, Gianluigi, SALVINI, Camilla, TADDEI, Gianluigi, TOSTI, Giulio, and VIRGILI, Annarosa
- Subjects
VULVAR diseases ,QUALITY standards ,PSYCHOSOMATIC medicine ,BODY mass index ,PATIENT reported outcome measures - Published
- 2022
- Full Text
- View/download PDF
7. Early detection of sporadic pancreatic cancer: strategic map for innovation--a white paper.
- Author
-
Kenner, Barbara J, Chari, Suresh T, Cleeter, Deborah F, and Go, Vay Liang W
- Subjects
Humans ,Carcinoma ,Pancreatic Ductal ,Pancreatic Neoplasms ,Diagnostic Imaging ,Biopsy ,Prognosis ,Molecular Diagnostic Techniques ,Predictive Value of Tests ,Interdisciplinary Communication ,Cooperative Behavior ,Biomedical Research ,International Cooperation ,Diffusion of Innovation ,Early Detection of Cancer ,Biomarkers ,Tumor ,Carcinoma ,Pancreatic Ductal ,Biomarkers ,Tumor ,Gastroenterology & Hepatology ,Clinical Sciences - Abstract
Innovation leading to significant advances in research and subsequent translation to clinical practice is urgently necessary in early detection of sporadic pancreatic cancer. Addressing this need, the Early Detection of Sporadic Pancreatic Cancer Summit Conference was conducted by Kenner Family Research Fund in conjunction with the 2014 American Pancreatic Association and Japan Pancreas Society Meeting. International interdisciplinary scientific representatives engaged in strategic facilitated conversations based on distinct areas of inquiry: Case for Early Detection: Definitions, Detection, Survival, and Challenges; Biomarkers for Early Detection; Imaging; and Collaborative Studies. Ideas generated from the summit have led to the development of a Strategic Map for Innovation built upon 3 components: formation of an international collaborative effort, design of an actionable strategic plan, and implementation of operational standards, research priorities, and first-phase initiatives. Through invested and committed efforts of leading researchers and institutions, philanthropic partners, government agencies, and supportive business entities, this endeavor will change the future of the field and consequently the survival rate of those diagnosed with pancreatic cancer.
- Published
- 2015
8. ESUR/ESUI position paper: developing artificial intelligence for precision diagnosis of prostate cancer using magnetic resonance imaging
- Author
-
Jochen Walz, Jonathan Richenberg, Tobias Penzkofer, Baris Turkbey, Jelle O. Barentsz, Anwar R. Padhani, Geert Villeirs, Vibeke Løgager, Masoom A. Haider, Valeria Panebianco, Olivier Rouvière, Georg Salomon, Ivo G. Schoots, Henkjan J. Huisman, and Radiology & Nuclear Medicine
- Subjects
Image-Guided Biopsy ,Male ,Artificial intelligence ,COMPUTER-AIDED DETECTION ,PREDICTION ,Disease ,artificial intelligence ,deep learning ,image-guided biopsy ,multiparametric magnetic resonance imaging ,prostate cancer ,Image-guided biopsy ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,SDG 3 - Good Health and Well-being ,Multiparametric magnetic resonance imaging ,Medicine and Health Sciences ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Neuroradiology ,PI-RADS ,medicine.diagnostic_test ,business.industry ,Prostatic Neoplasms ,Interventional radiology ,Urogenital ,Deep learning ,General Medicine ,PERFORMANCE ,medicine.disease ,Magnetic Resonance Imaging ,Workflow ,Software deployment ,030220 oncology & carcinogenesis ,Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] ,BIOPSY ,Position paper ,business ,600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit ,MRI - Abstract
Abstract Artificial intelligence developments are essential to the successful deployment of community-wide, MRI-driven prostate cancer diagnosis. AI systems should ensure that the main benefits of biopsy avoidance are delivered while maintaining consistent high specificities, at a range of disease prevalences. Since all current artificial intelligence / computer-aided detection systems for prostate cancer detection are experimental, multiple developmental efforts are still needed to bring the vision to fruition. Initial work needs to focus on developing systems as diagnostic supporting aids so their results can be integrated into the radiologists’ workflow including gland and target outlining tasks for fusion biopsies. Developing AI systems as clinical decision-making tools will require greater efforts. The latter encompass larger multicentric, multivendor datasets where the different needs of patients stratified by diagnostic settings, disease prevalence, patient preference, and clinical setting are considered. AI-based, robust, standard operating procedures will increase the confidence of patients and payers, thus enabling the wider adoption of the MRI-directed approach for prostate cancer diagnosis. Key Points • AI systems need to ensure that the benefits of biopsy avoidance are delivered with consistent high specificities, at a range of disease prevalence. • Initial work has focused on developing systems as diagnostic supporting aids for outlining tasks, so they can be integrated into the radiologists’ workflow to support MRI-directed biopsies. • Decision support tools require a larger body of work including multicentric, multivendor studies where the clinical needs, disease prevalence, patient preferences, and clinical setting are additionally defined.
- Published
- 2021
9. PCR performance for the diagnosis of cutaneous leishmaniasis caused by Leishmania viannia complex using biopsy samples, compared with exudate samples from skin lesions on filter paper
- Author
-
Max Carlos Ramírez-Soto, Mercedes Maritza Quispe-Flórez, Yahanda Gisela Apaza-Castillo, Rosa Luz Pacheco-Venero, and Elsa Gladys Aguilar-Ancori
- Subjects
Exudate ,Pathology ,medicine.medical_specialty ,diagnosis ,Biopsy ,030231 tropical medicine ,Leishmaniasis, Cutaneous ,Diagnostic concordance ,Polymerase Chain Reaction ,Sensitivity and Specificity ,cutaneous leishmaniasis ,03 medical and health sciences ,0302 clinical medicine ,Leishmania viannia ,Cutaneous leishmaniasis ,Peru ,Skin Ulcer ,medicine ,Humans ,filter paper ,030212 general & internal medicine ,skin biopsy ,Skin ,Leishmania ,medicine.diagnostic_test ,Filter paper ,business.industry ,Public Health, Environmental and Occupational Health ,Exudates and Transudates ,General Medicine ,DNA, Protozoan ,medicine.disease ,Infectious Diseases ,Skin biopsy ,Parasitology ,medicine.symptom ,business ,Skin lesion ,purl.org/pe-repo/ocde/ford#3.03.06 [https] - Abstract
Background Cutaneous leishmaniasis (CL) is generally diagnosed by molecular methods, including PCR, using biopsy samples, skin scrapings and clinical exudates. In this study, we assessed the PCR performance for diagnosis of CL using skin of biopsy samples vs PCR of skin lesion exudate samples on filter paper and compared the diagnostic concordance of PCR using both sampling methods. Methods We assessed the PCR performance using 80 skin biopsy samples and 80 filter paper samples containing exudates from skin lesions obtained from 74 patients with clinical suspicion of CL in Cusco, Peru. Results : PCR using skin biopsy samples had superior diagnostic accuracy compared with filter paper PCR (62.5% [50/80] vs 38.7% [31/80], respectively; p˂0.005) and the diagnostic concordance between both sampling methods was ‘moderate’ (kappa coefficient=0.50, 95% CI 0.98 to 1.0). Conclusions PCR using biopsy samples remains the standard for diagnosis of CL.
- Published
- 2020
10. Canadian Association of Radiologists Prostate MRI White Paper.
- Author
-
Chang, Silvia D., Reinhold, Caroline, Kirkpatrick, Iain D. C., Clarke, Sharon E., Schieda, Nicola, Hurrell, Casey, Cool, Derek W., Tunis, Adam S., Alabousi, Abdullah, Diederichs, Brendan J., and Haider, Masoom A.
- Subjects
- *
DIGITAL image processing , *MEN'S health , *REPORT writing , *BIOPSY , *MAGNETIC resonance imaging , *RADIOLOGIC technology , *QUALITY assurance , *PROSTATE tumors - Abstract
Prostate cancer is the most common malignancy and the third most common cause of death in Canadian men. In light of evolving diagnostic pathways for prostate cancer and the increased use of MRI, which now includes its use in men prior to biopsy, the Canadian Association of Radiologists established a Prostate MRI Working Group to produce a white paper to provide recommendations on establishing and maintaining a Prostate MRI Programme in the context of the Canadian healthcare system. The recommendations, which are based on available scientific evidence and/or expert consensus, are intended to maintain quality in image acquisition, interpretation, reporting and targeted biopsy to ensure optimal patient care. The paper covers technique, reporting, quality assurance and targeted biopsy considerations and includes appendices detailing suggested reporting templates, quality assessment tools and sample image acquisition protocols relevant to the Canadian healthcare context. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
11. European Association of Urology Position Paper on the Prevention of Infectious Complications Following Prostate Biopsy
- Author
-
Franck Bruyère, T. Tony Cai, Jeremy Grummet, Konstantinos Dimitropoulos, Tunde Mezei, Muhammad Imran Omar, Gernot Bonkat, Benjamin Pradere, Nicolas Mottet, Yuhong Yuan, Adrian Pilatz, Suzanne E. Geerlings, Rajan Veeratterapillay, Florian M.E. Wagenlehner, Sören Schubert, Riccardo Bartoletti, Béla Köves, Wout Devlies, Infectious diseases, AII - Infectious diseases, and APH - Quality of Care
- Subjects
Male ,medicine.medical_specialty ,Prostate biopsy ,medicine.drug_class ,Biopsy ,Urology ,Antibiotics ,030232 urology & nephrology ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,media_common.cataloged_instance ,European union ,media_common ,medicine.diagnostic_test ,Transperineal approach ,business.industry ,Prostate ,Bacterial Infections ,Antibiotic Prophylaxis ,030220 oncology & carcinogenesis ,Position paper ,business - Abstract
The transperineal approach is preferred to reduce prostate biopsy (PB)-related infections. Fluoroquinolones are suspended for prophylaxis of PB in the European Union; therefore, alternative antibiotics based on local resistance, or targeted prophylaxis, in conjunction with povidone-iodine rectal preparation are recommended for transrectal PB.
- Published
- 2021
12. Position paper: recommendations for a digital mammography quality assurance program V4.0
- Author
-
Heggie, J. C. P., Barnes, P., Cartwright, L., Diffey, J., Tse, J., Herley, J., McLean, I. D., Thomson, F. J., Grewal, R. K., and Collins, L. T.
- Published
- 2017
- Full Text
- View/download PDF
13. Comparison of Filter Paper and Gelfoam as Templates for Orientation of Endoscopic Duodenal Biopsies.
- Author
-
BALASUBRAMANIAN, PRIYAVADHANA, BADHE, BHAWANA ASHOK, GANESH, RAJESH NACHIAPPA, PANICKER, LAKSHMI C., and MOHAN, PAZHANIVEL
- Subjects
- *
FILTER paper , *ENTEROCYTES , *EOSINOPHILS , *BIOPSY , *STATISTICS - Abstract
Introduction: Proper orientation of endoscopic mucosal biopsies is crucial for accurate histomorphologic assessment. Aim: To compare the morphology on two different templates, filter paper and gelfoam for orientation of biopsies. Materials and Methods: In this study a total of 21 duodenal biopsies were studied which were taken from the same site, fixed and oriented on wet filter paper and gelfoam in formalin, from patients who presented with malabsorptive symptoms. Histomorphological parameters studied were villous architecture, crypt architecture, intraepithelial lymphocyte (IEL) count per 100 enterocytes, villous tip IEL count per 20 enterocytes, inflammatory cells in lamina propria. Statistical analysis was done using IBM-SPSS software version 21. p-value <0.05 was considered as statistically significant. Results: Twenty-one biopsies were taken in both the templates. Authors had 18 biopsies for analysis as three sections on gelfoam were lost during processing. All the histomorphological parameters were studied and it was similar on both the templates. The level of agreement by kappa statistics was significant with kappa value of 0.727 for villous architecture, 0.852 for lamina propria inflammatory infiltrate, 1 for IEL and eosinophils in lamina propria with p-value of <0.001. Conclusion: Authors concluded, gelfoam or filter paper serves as a good template for proper orientation of tiny mucosal biopsies. However, further studies are needed on larger sample size to validate this finding. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
14. The International Endomyocardial Biopsy Position Paper: A Basis for Integration Into Modern Clinical Practice
- Author
-
María G. Crespo-Leiro and Jonathan G. Howlett
- Subjects
Heart Failure ,medicine.medical_specialty ,business.industry ,Biopsy ,Myocardium ,Heart ,Endomyocardial biopsy ,Clinical Practice ,medicine ,Position paper ,Humans ,Medical physics ,Cardiology and Cardiovascular Medicine ,business ,Endocardium - Published
- 2021
15. Electronic Consent Associated with Improved Start Times for Interventional Radiology Procedures versus Paper-Based Consents
- Author
-
Shah, Suken H.
- Subjects
Oncology ,Biopsy ,Ultrasound ,RIS ,Patterns of Care ,Computer applications ,Outcomes ,Interventional non-vascular ,CT - Abstract
Purpose Methods and materials Results Conclusion Personal information and conflict of interest References, Purpose: Digital healthcare transformation has rapidly accelerated during the COVID pandemic and has helped to improve the delivery of health care services. Digital health tools have been increasingly adopted to improve both the physician and patient care...
- Published
- 2023
- Full Text
- View/download PDF
16. Risikoadaptierte Prostatakarzinomfrüherkennung 2.0 – Positionspapier der Deutschen Gesellschaft für Urologie 2024.
- Author
-
Michel, Maurice Stephan, Gschwend, Jürgen E., Wullich, Bernd, Krege, Susanne, Bolenz, Christian, Merseburger, Axel S., Krabbe, Laura-Maria, Schultz-Lampel, Daniela, König, Frank, Haferkamp, Axel, and Hadaschik, Boris
- Subjects
MORTALITY prevention ,RISK assessment ,BIOPSY ,PROSTATE-specific antigen ,EARLY detection of cancer ,PROSTATE tumors ,MAGNETIC resonance imaging ,ALGORITHMS - Abstract
Copyright of Die Urologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
- Full Text
- View/download PDF
17. International liquid biopsy standardization alliance white paper
- Author
-
Gary J. Kelloff, Jennifer Boyle, Klaus Pantel, Dana E. Connors, Mark Stewart, Thomas Schlange, J.D. Alvarez, Susan M. Keating, Christian D. Rolfo, Lauren Leiman, Carolyn Hiller, Caroline C. Sigman, Massimo Cristofanilli, Jeff Allen, Emily Morgan, Diana M. Merino, Robert T. McCormack, María José Serrano, and A. Pia Sanzone
- Subjects
0301 basic medicine ,Knowledge management ,Standardization ,business.industry ,Biopsy ,Liquid Biopsy ,Hematology ,Precision medicine ,Neoplastic Cells, Circulating ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Alliance ,White paper ,Oncology ,Clinical decision making ,030220 oncology & carcinogenesis ,Health care ,Biomarkers, Tumor ,Medicine ,Humans ,Personalized medicine ,Liquid biopsy ,Precision Medicine ,business - Abstract
The promise of precision medicine as a model to customize health care to the individual patient is heavily dependent upon new genetic tools to classify and characterize diseases and their hosts. Liquid biopsies serve as a safe alternative to solid biopsies and are thus a useful and critical component to fully realizing personalized medicine. The International Liquid Biopsy Standardization Alliance (ILSA) comprises organizations and foundations that recognize the importance of working towards the global use of liquid biopsy in oncology practice to support clinical decision making and regulatory considerations and seek to promote it in their communities. This manuscript provides an overview of the independent liquid biopsy- and standardization-based programs engaged with ILSA, their objectives and progress to date, and the tools and resources each is developing to contribute to the field. It also describes the unique areas of effort as well as synergy found within the group.
- Published
- 2020
18. The 2019 Genitourinary Pathology Society (GUPS) White Paper on Contemporary Grading of Prostate Cancer
- Author
-
Jeffrey S. So, Rajal B. Shah, Brian D. Robinson, John C. Cheville, Angelo M. DeMarzo, Francesca Khani, Charles C. Guo, Ximing J. Yang, Fiona Maclean, Maurizio Colecchia, Rodolfo Montironi, Dilek Ertoy Baydar, Sara E. Wobker, Manju Aron, Eva Compérat, Warick Delprado, Mark A. Rubin, Mathieu Latour, Antonio Beltran, Lawrence D. True, Mahul B. Amin, Oleksandr N. Kryvenko, Jiaoti Huang, Qingnuan Kong, Georges J Netto, Cristina Magi-Galluzzi, L. Priya Kunju, Rohit Mehra, Rafael E. Jimenez, Ferran Algaba, Giovanna A. Giannico, Anil V. Parwani, Isabela Werneck da Cunha, Kiril Trpkov, Fadi Brimo, Santosh Menon, Tamara L. Lotan, Jane K. Nguyen, Hiroyuki Takahashi, Jonathan I. Epstein, Adeboye O. Osunkoya, Peter A. Humphrey, Jennifer Gordetsky, Debra L. Zynger, Donna E. Hansel, Samson W. Fine, Maria S. Tretiakova, Fabio Tavora, Michelle S. Hirsch, Ming Zhou, Hiroshi Miyamoto, Priti Lal, Epstein, J. I., Amin, M. B., Fine, S. W., Algaba, F., Aron, M., Baydar, D. E., Beltran, A. L., Brimo, F., Cheville, J. C., Colecchia, M., Comperat, E., da Cunha, I. W., Delprado, W., Demarzo, A. M., Giannico, G. A., Gordetsky, J. B., Guo, C. C., Hansel, D. E., Hirsch, M. S., Huang, J., Humphrey, P. A., Jimenez, R. E., Khani, F., Kong, Q., Kryvenko, O. N., Kunju, L. P., Lal, P., Latour, M., Lotan, T., Maclean, F., Magi-Galluzzi, C., Mehra, R., Menon, S., Miyamoto, H., Montironi, R., Netto, G. J., Nguyen, J. K., Osunkoya, A. O., Parwani, A., Robinson, B. D., Rubin, M. A., Shah, R. B., So, J. S., Takahashi, H., Tavora, F., Tretiakova, M. S., True, L., Wobker, S. E., Yang, X. J., Zhou, M., Zynger, D. L., and Trpkov, K.
- Subjects
Image-Guided Biopsy ,Male ,Pathology ,medicine.medical_specialty ,Consensus ,030232 urology & nephrology ,MEDLINE ,Pathology and Forensic Medicine ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,White paper ,Predictive Value of Tests ,Biopsy ,medicine ,Biomarkers, Tumor ,Humans ,610 Medicine & health ,Grading (tumors) ,medicine.diagnostic_test ,Genitourinary system ,business.industry ,Biopsy, Needle ,Prostatic Neoplasms ,General Medicine ,medicine.disease ,Immunohistochemistry ,Magnetic Resonance Imaging ,Medical Laboratory Technology ,Molecular Diagnostic Techniques ,030220 oncology & carcinogenesis ,Predictive value of tests ,Neoplasm Grading ,business - Abstract
Context.— Controversies and uncertainty persist in prostate cancer grading. Objective.— To update grading recommendations. Data Sources.— Critical review of the literature along with pathology and clinician surveys. Conclusions.— Percent Gleason pattern 4 (%GP4) is as follows: (1) report %GP4 in needle biopsy with Grade Groups (GrGp) 2 and 3, and in needle biopsy on other parts (jars) of lower grade in cases with at least 1 part showing Gleason score (GS) 4 + 4 = 8; and (2) report %GP4: less than 5% or less than 10% and 10% increments thereafter. Tertiary grade patterns are as follows: (1) replace “tertiary grade pattern” in radical prostatectomy (RP) with “minor tertiary pattern 5 (TP5),” and only use in RP with GrGp 2 or 3 with less than 5% Gleason pattern 5; and (2) minor TP5 is noted along with the GS, with the GrGp based on the GS. Global score and magnetic resonance imaging (MRI)-targeted biopsies are as follows: (1) when multiple undesignated cores are taken from a single MRI-targeted lesion, an overall grade for that lesion is given as if all the involved cores were one long core; and (2) if providing a global score, when different scores are found in the standard and the MRI-targeted biopsy, give a single global score (factoring both the systematic standard and the MRI-targeted positive cores). Grade Groups are as follows: (1) Grade Groups (GrGp) is the terminology adopted by major world organizations; and (2) retain GS 3 + 5 = 8 in GrGp 4. Cribriform carcinoma is as follows: (1) report the presence or absence of cribriform glands in biopsy and RP with Gleason pattern 4 carcinoma. Intraductal carcinoma (IDC-P) is as follows: (1) report IDC-P in biopsy and RP; (2) use criteria based on dense cribriform glands (>50% of the gland is composed of epithelium relative to luminal spaces) and/or solid nests and/or marked pleomorphism/necrosis; (3) it is not necessary to perform basal cell immunostains on biopsy and RP to identify IDC-P if the results would not change the overall (highest) GS/GrGp part per case; (4) do not include IDC-P in determining the final GS/GrGp on biopsy and/or RP; and (5) “atypical intraductal proliferation (AIP)” is preferred for an intraductal proliferation of prostatic secretory cells which shows a greater degree of architectural complexity and/or cytological atypia than typical high-grade prostatic intraepithelial neoplasia, yet falling short of the strict diagnostic threshold for IDC-P. Molecular testing is as follows: (1) Ki67 is not ready for routine clinical use; (2) additional studies of active surveillance cohorts are needed to establish the utility of PTEN in this setting; and (3) dedicated studies of RNA-based assays in active surveillance populations are needed to substantiate the utility of these expensive tests in this setting. Artificial intelligence and novel grading schema are as follows: (1) incorporating reactive stromal grade, percent GP4, minor tertiary GP5, and cribriform/intraductal carcinoma are not ready for adoption in current practice.
- Published
- 2020
19. Filter paper-assisted cell transfer (FaCT) technique: A novel cell-sampling technique for intraoperative diagnosis of central nervous system tumors
- Author
-
Kuniko Sakamaki, Jumpei Kawamura, Sadahito Kuwao, Shingo Kamoshida, Yurie Hayashi, Takaaki Shimakata, Kenji Kawai, and Tamami Denda
- Subjects
Cancer Research ,Pathology ,medicine.medical_specialty ,Frozen section procedure ,Filter paper ,medicine.diagnostic_test ,business.industry ,Cell ,Central nervous system ,Cancer ,Diagnostic concordance ,medicine.disease ,Cell morphology ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Biopsy ,medicine ,Radiology ,business ,030217 neurology & neurosurgery - Abstract
BACKGROUND Intraoperative diagnosis of central nervous system (CNS) tumors provides critical guidance to surgeons in the determination of surgical resection margins and treatment. The techniques and preparations used for the intraoperative diagnosis of CNS tumors include frozen sectioning and cytologic methods (squash smear and touch imprint). Cytologic specimens, which do not have freezing artifacts, are important as an adjuvant tool to frozen sections. However, if the amount of submitted tissue samples is limited, then it is difficult to prepare both frozen sections and squash smears or touch imprint specimens from a single sample at the same time. Therefore, the objective of this study was to derive cells directly from filter paper on which tumor samples are placed. METHODS The authors established the filter paper-assisted cell transfer (FaCT) smear technique, in which tumor cells are transferred onto a glass slide directly from the filter paper sample spot after the biopsy is removed. RESULTS Cell yields and diagnostic accuracy of the FaCT smears were assessed in 40 CNS tumors. FaCT smears had ample cell numbers and well preserved cell morphology sufficient for cytologic diagnosis, even if the submitted tissues were minimal. The overall diagnostic concordance rates between frozen sections and FaCT smears were 90% and 87.5%, respectively (no significant differences). When combining FaCT smears with frozen sections, the diagnostic concordance rate rose to 92.5%. CONCLUSIONS The current results suggest that the FaCT smear technique is a simple and effective processing method that has significant value for intraoperative diagnosis of CNS tumors. Cancer Cytopathol 2017;125:277–282. © 2016 American Cancer Society.
- Published
- 2017
20. SIIV position paper: clinical approach to vulval diseases. Need for quality standards
- Author
-
Carmine CARRIERO, Pina BELFIORE, Monica CORAZZA, Stefano CRIPPA, Angelina DE MAGNIS, Luciano MARIANI, Leonardo MICHELETTI, Eleonora P. PRETI, Mario PRETI, Gianluigi RADICI, Camilla SALVINI, Gianluigi TADDEI, Giulio TOSTI, and Annarosa VIRGILI
- Subjects
History ,Mucous Membrane ,Physical examination ,Biopsy ,Vulva ,Terminology ,Obstetrics and Gynecology ,Humans ,Female ,Vulvar Diseases - Abstract
This paper summarizes the position of the Italian Society of Vulvology on the clinical approach to vulval disease. A thorough history (general medical, gynaecological, and vulval history) is essential for a successful and fruitful vulvological examination. Characteristics of pruritus (itch) and pain, that are the two main vulval symptoms, should be collected and reported with precision, according to duration, temporal course, location, provocation, and intensity. Physical examination must consider both the general condition of the patient and the specific vulval region, that must be examined following a standardized methodology. The physical examination of the vulva is carried out with naked eye and adequate natural or halogen lighting. The subsequent use of instrumental magnification can be considered on particular parts of skin/mucosa, already highlighted with the first inspection. Also, palpation is essential, allowing to appreciate physical features of vulval lesions: consistency, surface, soreness, adherence to underlying plans. Finally, the five-step approach of the International Society for the Study of Vulvo-vaginal Disease about Terminology and Classification of Vulvar Dermatological Disorders (2012) is summarized. A vulval biopsy may be useful in the following situations: when clinical diagnosis is uncertain, lesion not responding to treatment; histologic confirmation for a clinical diagnosis and exclusion or confirmation of a suspected neoplastic intraepithelial or invasive pathology.
- Published
- 2022
21. Cutaneous leishmaniasis: PCR of filter paper blots from an ulcer base is an alternative to biopsy
- Author
-
Hanspeter Marti, Matthias Schmuth, and Maria Kitchen
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,Filter paper ,030231 tropical medicine ,Dermatology ,Biology ,medicine.disease ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Cutaneous leishmaniasis ,Biopsy ,medicine ,Base (exponentiation) - Published
- 2018
22. Beyond chronic kidney disease: the diagnosis of Renal Disease in the Elderly as an unmet need. A position paper endorsed by Italian Society of Nephrology (SIN) and Italian Society of Geriatrics and Gerontology (SIGG)
- Author
-
Loreto Gesualdo, Giuliano Brunori, Dario Leosco, Filippo Aucella, Raffaele Antonelli-Incalzi, Andrea Corsonello, Aucella, Filippo, Corsonello, Andrea, Leosco, Dario, Brunori, Giuliano, Gesualdo, Loreto, and Antonelli-Incalzi, Raffaele
- Subjects
Male ,Nephrology ,medicine.medical_specialty ,Consensus ,Referral ,Biopsy ,030232 urology & nephrology ,Psychological intervention ,Disease ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,Nephropathy ,Nephrologists ,Renal disease ,03 medical and health sciences ,0302 clinical medicine ,Elderly ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,Chronic kidney disease ,medicine ,Humans ,Renal Insufficiency, Chronic ,Position papers and Guidelines ,Intensive care medicine ,Geriatric Assessment ,Referral and Consultation ,Renal ageing ,Aged ,Aged, 80 and over ,Patient Care Team ,Geriatrics ,Health Services Needs and Demand ,medicine.diagnostic_test ,business.industry ,Age Factors ,Geriatricians ,Prognosis ,medicine.disease ,female genital diseases and pregnancy complications ,Female ,Renal biopsy ,business ,Needs Assessment ,Geriatric ,Kidney disease - Abstract
The dramatic increase in prevalence of chronic kidney disease (CKD) with ageing makes the recognition and correct referral of these patients of paramount relevance in order to implement interventions preventing or delaying the development of CKD complications and end-stage renal disease. Nevertheless, several issues make the diagnosis of CKD in the elderly cumbersome. Among these are age related changes in structures and functions of the kidney, which may be difficult to distinguish from CKD, and multimorbidity. Thus, symptoms, clinical findings and laboratory abnormalities should be considered as potential clues to suspect CKD and to suggest screening. Comprehensive geriatric assessment is essential to define the clinical impact of CKD on functional status and to plan treatment. Correct patient referral is very important: patients with stage 4–5 CKD, as well as those with worsening proteinuria or progressive nephropathy (i.e. eGFR reduction > 5 ml/year) should be referred to nephrologist. Renal biopsy not unfrequently may be the key diagnostic exam and should not be denied simply on the basis of age. Indeed, identifying the cause(s) of CKD is highly desirable to perform a targeted therapy against the pathogenetic mechanisms of CKD, which complement and may outperform in efficacy the general measures for CKD.
- Published
- 2019
23. Management of the clinically N0 neck in early-stage oral squamous cell carcinoma (OSCC). An EACMFS position paper
- Author
-
Leandros V. Vassiliou, Nicholas Kalavrezos, Sylvie Testelin, Julio Acero, Frank Hölzle, Aakshay Gulati, Satheesh Prabhu, Klaus-Dietrich Wolff, and Iain Hutchison
- Subjects
Oncology ,medicine.medical_specialty ,medicine.medical_treatment ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Biopsy ,medicine ,Stage (cooking) ,Lymph node ,medicine.diagnostic_test ,business.industry ,Neck dissection ,030206 dentistry ,Sentinel node ,medicine.disease ,Occult ,stomatognathic diseases ,medicine.anatomical_structure ,Otorhinolaryngology ,Cervical lymph nodes ,030220 oncology & carcinogenesis ,Surgery ,Oral Surgery ,business - Abstract
Metastasis of oral squamous cell carcinoma (OSCC) to the cervical lymph nodes has a significant impact on prognosis. Accurate staging of the neck is important in order to deliver appropriate treatment for locoregional control of the disease and for prognosis. The management of the neck in early, low volume disease (clinically T1/T2 oral cavity tumours) has long been debated. The risk of occult nodal involvement in cT1/T2 OSCC is estimated around 20-30%. We describe the natural evolutionary history of OSCC and its patterns of spread and metastasis to the local lymphatic basins. We discuss most published literature and studies on management of the clinically negative neck (cN0). Particular focus is given to prospective randomized trials comparing the outcomes of upfront elective neck dissection against the observational stance, and we summarize the results of the sentinel node biopsy studies. The paper discusses the significance of the primary tumour histological characteristics and specifically the tumour's depth of invasion (DOI) and its impact on predicting nodal metastasis. The DOI has been incorporated in the TNM staging highlighting its significance in aiding the treatment decision making and this is reflected in world-wide oncological guidelines. The critical analysis of all available literature amalgamates the existing evidence in early OSCC and provides recommendations in the management of the clinically N0 neck.
- Published
- 2020
24. Application of dried-droplets deposited on pre-cut filter paper disks for quantitative LA-ICP-MS imaging of biologically relevant minor and trace elements in tissue samples
- Author
-
Balazs Hegedus, Maximilian Bonta, and Andreas Limbeck
- Subjects
Male ,Mesothelioma ,Paper ,Analyte ,Swine ,Biopsy ,Analytical chemistry ,02 engineering and technology ,Standard solution ,Kidney ,01 natural sciences ,Biochemistry ,Mass Spectrometry ,Analytical Chemistry ,Biological specimen ,Calibration ,Animals ,Humans ,Environmental Chemistry ,Spectroscopy ,Aged ,Detection limit ,Aqueous solution ,Filter paper ,Chemistry ,010401 analytical chemistry ,Trace element ,Reference Standards ,021001 nanoscience & nanotechnology ,Trace Elements ,0104 chemical sciences ,Liver ,0210 nano-technology - Abstract
In this work, a novel calibration approach for minor and trace element quantification in LA-ICP-MS imaging of biological tissues is presented. Droplets of aqueous standard solutions are deposited onto pre-cut pieces of filter paper, allowed to dry, and sputtered with a thin gold layer for use as pseudo-internal standard. Analysis of the standards using LA-ICP-MS is performed using radial line-scans across the filters. In contrast to conventionally used preparation of matrix-matched tissue standards, the dried-droplet approach offers a variety of advantages: The standards are easy to prepare, no characterization of the standards using acid digestion is required, no handling of biological materials is necessary, and the concentration range, as well the number of investigated analytes is almost unlimited. The proposed quantification method has been verified using homogenized tissue standards with known analyte concentrations before being applied to a human malignant mesothelioma biopsy from a patient who had not received any chemotherapeutic treatment. Elemental distribution images were acquired at a lateral resolution of 40 μm per pixel, limits of detection ranging from 0.1 μg g(-1) (Mn, Ni, Cu, Zn) to 13.2 μg g(-1) (K) were reached.
- Published
- 2016
25. Optical Biopsy: Automated Classification of Airway Endoscopic Findings Using a Convolutional Neural Network.
- Author
-
Dunham ME, Kong KA, McWhorter AJ, and Adkins LK
- Subjects
- Humans, Laryngeal Diseases classification, Laryngeal Diseases diagnosis, Laryngeal Neoplasms classification, Laryngeal Neoplasms diagnosis, Laryngeal Neoplasms pathology, Larynx pathology, Machine Learning, Artificial Intelligence, Biopsy methods, Image Interpretation, Computer-Assisted methods, Laryngeal Diseases pathology, Laryngoscopy methods, Neural Networks, Computer
- Abstract
Objectives/hypothesis: Create an autonomous computational system to classify endoscopy findings., Study Design: Computational analysis of vocal fold images at an academic, tertiary-care laryngology practice., Methods: A series of normal and abnormal vocal fold images were obtained from the image database of an academic tertiary care laryngology practice. The benign images included normals, nodules, papilloma, polyps, and webs. A separate set of carcinoma and leukoplakia images comprised a single malignant-premalignant class. All images were classified with their existing labels. Images were randomly withheld from each class for testing. The remaining images were used to train and validate a neural network for classifying vocal fold lesions. Two classifiers were developed. A multiclass system classified the five categories of benign lesions. A separate analysis was performed using a binary classifier trained to distinguish malignant-premalignant from benign lesions., Results: Precision ranged from 71.7% (polyps) to 89.7% (papilloma), and recall ranged from 70.0% (papilloma) to 88.0% (nodules) for the benign classifier. Overall accuracy for the benign classifier was 80.8%. The binary classifier correctly identified 92.0% of the malignant-premalignant lesions with an overall accuracy of 93.0%., Conclusions: Autonomous classification of endoscopic images with artificial intelligence technology is possible. Better network implementations and larger datasets will continue to improve classifier accuracy. A clinically useful optical cancer screening system may require a multimodality approach that incorporates nonvisual spectra., Level of Evidence: NA Laryngoscope, 132:S1-S8, 2022., (© 2020 The American Laryngological, Rhinological and Otological Society, Inc.)
- Published
- 2022
- Full Text
- View/download PDF
26. The management of primary mediastinal B‐cell lymphoma: a British Society for Haematology Good Practice Paper
- Author
-
Andrew Davies, Sally F. Barrington, Timothy M Illidge, George A. Follows, Kate Cwynarski, Maria A V Marzolini, and Simon Stern
- Subjects
Male ,medicine.medical_specialty ,Lymphoma, B-Cell ,Biopsy ,Pregnancy, High-Risk ,MEDLINE ,Mediastinal Neoplasms ,Patient care ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Recurrence ,Positron Emission Tomography Computed Tomography ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Thrombophilia ,Limited evidence ,Good practice ,Grading (tumors) ,Positron Emission Tomography-Computed Tomography ,Salvage Therapy ,Clinical Trials as Topic ,Manchester Cancer Research Centre ,business.industry ,ResearchInstitutes_Networks_Beacons/mcrc ,Hematopoietic Stem Cell Transplantation ,Chemoradiotherapy ,Hematology ,Evidence-based medicine ,medicine.disease ,Combined Modality Therapy ,Infertility ,030220 oncology & carcinogenesis ,Family medicine ,Female ,Immunotherapy ,Primary mediastinal B-cell lymphoma ,business ,Pregnancy Complications, Neoplastic ,030215 immunology - Abstract
This Good Practice Paper was compiled according to the British Society for Haematology (BSH) process at http://www.b-s-h.org.uk/guidelines. The BSH produces Good Practice Papers to recommend good practice in areas where there is a limited evidence base but for which a degree of consensus or uniformity is likely to be beneficial to patient care. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) nomenclature was used to evaluate levels of evidence and to assess the strength of recommendations. The GRADE criteria can be found at http://www.gradeworkinggroup.org and is also detailed in Table 1.
- Published
- 2019
27. Impact of gross-total resection versus other extent of resections for the overall survival of anaplastic astrocytoma. A systematic literature review.
- Author
-
Chaulagain, Dipak, Smolanka, Volodymyr, Smolanka, Andriy, and Munakomi, Sunil
- Subjects
OVERALL survival ,ASTROCYTOMAS ,CONFERENCE papers ,ELECTRONIC information resource searching ,ANAPLASTIC thyroid cancer ,BIOPSY - Abstract
Aim: We aim to assess the overall survival (OS) in patients with Anaplastic Astrocytoma (AA) undergoing gross total resection (GTR) as compared to partial resection (PR) subtotal resection (STR), or biopsy. Methods: This systematic review followed Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) guidelines. An electronic search from PubMed/Medline was conducted from their inception to 26th April 2022. We included AA patients undergoing any surgical intervention resulting in GTR, PR, STR or biopsy. We did not include letters, case reports, abstracts, conference papers, reviews, and studies where full text was unavailable. We included only those articles which were published in English. Results: Five cohorts were used in this study. Two studies assessed OS in GTR, PR/STR and biopsy, while one study compared GTR and STR/biopsy. Another study was used to compare OS between GTR and local excision/STR, and another was used to assess the complications/benefits of these surgeries. Three studies showed a significant increase in OS in patients who underwent GTR compared to the other interventions, while one study showed a non-significant effect on OS (p= 0.249). Conclusion: Our study concluded a significant increase in OS when patients with AA had GTR instead of STR, PR or biopsy. Although these surgeries might carry some disadvantages, GTR allows a more positive effect on neurological status. Still, more studies need to be conducted to assess the efficiency of these surgeries. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
28. Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology
- Author
-
Susan Muller, Yi-Shing Lisa Cheng, John E. Fantasia, Zoya B. Kurago, and Alan Gould
- Subjects
medicine.medical_specialty ,Biopsy ,MEDLINE ,Disease ,Pathology and Forensic Medicine ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,stomatognathic system ,Risk Factors ,Oral and maxillofacial pathology ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,medicine.diagnostic_test ,business.industry ,030206 dentistry ,medicine.disease ,Dermatology ,Surgery ,stomatognathic diseases ,Cell Transformation, Neoplastic ,Fluorescent Antibody Technique, Direct ,030220 oncology & carcinogenesis ,Etiology ,Position paper ,Oral lichen planus ,Oral Surgery ,Differential diagnosis ,business ,Lichen Planus, Oral - Abstract
Despite being one of the most common oral mucosal diseases and recognized as early as 1866, oral lichen planus (OLP) is still a disease without a clear etiology or pathogenesis, and with uncertain premalignant potential. More research is urgently needed; however, the research material must be based on an accurate diagnosis. Accurate identification of OLP is often challenging, mandating inclusion of clinico-pathological correlation in the diagnostic process. This article summarizes current knowledge regarding OLP, discusses the challenges of making an accurate diagnosis, and proposes a new set of diagnostic criteria upon which to base future research studies. A checklist is also recommended for clinicians to provide specific information to pathologists when submitting biopsy material. The diagnostic process of OLP requires continued clinical follow-up after initial biopsy, because OLP mimics can manifest, necessitating an additional biopsy for direct immunofluorescence study and/or histopathological evaluation in order to reach a final diagnosis.
- Published
- 2016
29. Dysplasia in oral lichen planus: relevance, controversies and challenges. A position paper
- Author
-
González-Moles, Miguel Ángel, Warnakulasuriya, Saman, González-Ruiz, Isabel, Ayén, Ángela, González-Ruiz, Lucía, Ruiz-Ávila, Isabel, Ramos-García, Pablo, [González-Moles,MA, González-Ruiz,I, Ramos-García,P] School of Dentistry, University of Granada, Granada, Spain. [González-Moles,MA, Ruiz-Ávila,I, Ramos-García,P] Instituto de Investigación Biosanitaria ibs. Granada, Granada, Spain. [González-Moles,MA, and Warnakulasuriya,S] WHO Collaborating Group for Oral Cancer. [Warnakulasuriya,S] Faculty of Dental, Oral & Craniofacial Sciences, King's College London, London, UK. [Ayén,A] Dermatology Service, San Cecilio Hospital Complex, Granada, Spain. [González-Ruiz,L] Dermatology Service, Ciudad Real General University Hospital, Ciudad Real, Spain. [Ruiz-Ávila,I] Pathology Service, San Cecilio Hospital Complex, Granada, Spain.
- Subjects
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Dentistry::Pathology, Oral [Medical Subject Headings] ,Hyperplasia ,Neoplasias de la boca ,Diseases::Neoplasms::Neoplastic Processes::Carcinogenesis::Cell Transformation, Neoplastic [Medical Subject Headings] ,Diseases::Stomatognathic Diseases::Mouth Diseases [Medical Subject Headings] ,Oral cancer ,Biopsy ,Diseases::Stomatognathic Diseases::Mouth Diseases::Lichen Planus, Oral [Medical Subject Headings] ,Epithelial dysplasia ,Hiperplasia ,Epithelium ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Biopsia ,Liquen plano oral ,Amaurosis congénita de Leber ,Oral lichen planus ,Epitelio ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsy [Medical Subject Headings] ,Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Hyperplasia [Medical Subject Headings] ,Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Aggression [Medical Subject Headings] ,Diseases::Stomatognathic Diseases::Mouth Diseases::Mouth Neoplasms [Medical Subject Headings] ,Anatomy::Tissues::Epithelium [Medical Subject Headings] - Abstract
Background Patients with oral lichen planus (OLP) have an increased risk of oral cancer. For this reason, OLP is classified as an oral potentially malignant disorder. However, the precise personal (or individual) risk is unknown. Recent meta-analytical studies have reported that dysplastic OLP may transform to cancer in around 6% of cases, while the rate of transformation is lower (
- Published
- 2021
30. Re: 'ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee'
- Author
-
Jing Li, Xiao Ma, and Kefei Cui
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Thyroid ,Biopsy, Fine-Needle ,MEDLINE ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Text mining ,White paper ,030220 oncology & carcinogenesis ,Biopsy ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Radiology ,Thyroid Nodule ,business - Published
- 2017
31. Origami-paper-based device for microvesicle/exosome preconcentration and isolation.
- Author
-
Kim, Hyerin, Lee, Kyu Hyoung, Han, Sung Il, Lee, Dongho, Chung, Seok, Lee, Dohwan, and Lee, Jeong Hoon
- Subjects
- *
BIOMARKERS , *BIOLOGICAL tags , *DNA folding , *IONS , *BIOPSY , *EXOSOMES - Abstract
Microvesicles and exosomes are promising liquid biopsy biomarkers. However, conventional isolation techniques damage and contaminate the biomarkers. We developed an origami-paper-based device for effective isolation of biomarkers with less damage and in fewer steps. The multi-folded device enables the preconcentration of the microvesicles/exosomes on specific layers (∼5-fold) by the ion concentration polarization technique and they were simply isolated from the rest of the sample by unfolding the device. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
32. Dysplasia in oral lichen planus: relevance, controversies and challenges. A position paper
- Author
-
Saman Warnakulasuriya, Lucía González-Ruiz, Miguel Ángel González-Moles, Pablo Ramos-García, Isabel Ruiz-Ávila, Isabel González-Ruiz, and Ángela Ayén
- Subjects
Epithelial dysplasia ,medicine.medical_specialty ,Biopsy ,Review ,Malignancy ,taste ,stomatognathic system ,Oral Cancer and Potentially malignant disorders ,Oral and maxillofacial pathology ,medicine ,Humans ,General Dentistry ,UNESCO:CIENCIAS MÉDICAS ,Mouth neoplasm ,child ,Hyperplasia ,medicine.diagnostic_test ,oral mucosa ,business.industry ,Oral cancer ,Cancer ,medicine.disease ,Dermatology ,stomatognathic diseases ,Cell Transformation, Neoplastic ,Otorhinolaryngology ,covid-19 ,Dysplasia ,Oral lichen planus ,Surgery ,Mouth Neoplasms ,business ,Mouth Diseases ,Lichen Planus, Oral - Abstract
Background: Patients with oral lichen planus (OLP) have an increased risk of oral cancer. For this reason, OLP is classified as an oral potentially malignant disorder. However, the precise personal (or individual) risk is unknown. Recent meta-analytical studies have reported that dysplastic OLP may transform to cancer in around 6% of cases, while the rate of transformation is lower (
- Published
- 2021
- Full Text
- View/download PDF
33. Position paper: recommendations for a digital mammography quality assurance program V4.0
- Author
-
Jennifer Diffey, Jcp Heggie, F. J. Thomson, Lucy Cartwright, R. K. Grewal, P. Barnes, I. D. McLean, Lee Collins, J. Herley, and J. Tse
- Subjects
Quality Control ,medicine.medical_specialty ,Digital mammography ,Quality Assurance, Health Care ,Image quality ,media_common.quotation_subject ,Biopsy ,Biomedical Engineering ,Biophysics ,General Physics and Astronomy ,Teleradiology ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Mammography ,Humans ,Radiology, Nuclear Medicine and imaging ,Quality (business) ,Medical physics ,media_common ,medicine.diagnostic_test ,business.industry ,Digital imaging ,030220 oncology & carcinogenesis ,Position paper ,business ,Quality assurance - Abstract
In 2001 the ACPSEM published a position paper on quality assurance in screen film mammography which was subsequently adopted as a basis for the quality assurance programs of both the Royal Australian and New Zealand College of Radiologists (RANZCR) and of BreastScreen Australia. Since then the clinical implementation of digital mammography has been realised and it has become evident that existing screen-film protocols were not appropriate to assure the required image quality needed for reliable diagnosis or to address the new dose implications resulting from digital technology. In addition, the advantages and responsibilities inherent in teleradiology are most critical in mammography and also need to be addressed. The current document is the result of a review of current overseas practice and local experience in these areas. At this time the technology of digital imaging is undergoing significant development and there is still a lack of full international consensus about some of the detailed quality control (QC) tests that should be included in quality assurance (QA) programs. This document describes the current status in digital mammography QA and recommends test procedures that may be suitable in the Australasian environment. For completeness, this document also includes a review of the QA programs required for the various types of digital biopsy units used in mammography. In the future, international harmonisation of digital quality assurance in mammography and changes in the technology may require a review of this document. Version 2.0 represented the first of these updates and key changes related to image quality evaluation, ghost image evaluation and interpretation of signal to noise ratio measurements. In Version 3.0 some significant changes, made in light of further experience gained in testing digital mammography equipment were introduced. In Version 4.0, further changes have been made, most notably digital breast tomosynthesis (DBT) testing and QC have been addressed. Some additional testing for conventional projection imaging has been added in order that sites may have the capability to undertake dose surveys to confirm compliance with diagnostic reference levels (DRLs) that may be established at the National or State level. A key recommendation is that dosimetry calculations are now to be undertaken using the methodology of Dance et al. Some minor changes to existing facility QC tests have been made to ensure the suggested procedures align with those most recently adopted by the Royal Australian and New Zealand College of Radiologists and BreastScreen Australia. Future updates of this document may be provided as deemed necessary in electronic format on the ACPSEM's website ( https://www.acpsem.org.au/whatacpsemdoes/standards-position-papers and see also http://www.ranzcr.edu.au/quality-a-safety/radiology/practice-quality-activities/mqap ).
- Published
- 2017
34. Position paper on screening for breast cancer by the European Society of Breast Imaging (EUSOBI) and 30 national breast radiology bodies from Austria, Belgium, Bosnia and Herzegovina, Bulgaria, Croatia, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Israel, Lithuania, Moldova, The Netherlands, Norway, Poland, Portugal, Romania, Serbia, Slovakia, Spain, Sweden, Switzerland and Turkey
- Author
-
Christiane K. Kuhl, Jana Slobodníková, Boris Brkljačić, Pietro Panizza, Tamar Sella, Federica Pediconi, Henk J. Baarslag, Catherine Colin, José Carlos Marques, Katalin Ormandi, Oswald Graf, Margarete Mortier, Gormlaith Hargaden, Gul Esen, Andrew Evans, Gérard de Geer, Laura Martincich, Ruud M. Pijnappel, Ilse Vejborg, Gianni Saguatti, Katja Pinker, Julia Camps Herrero, Hildegunn Siv Aase, Elzbieta Luczynska, T. Rissanen, Corinne Balleyguier, Ritse M. Mann, Michael H. Fuchsjaeger, Marina Álvarez, Ruta Briediene, Ulrich Bick, Maret Talk, Ásbjörn Jónsson, Jan Daneš, Gabor Forrai, Athina Vourtsis, Pascal A. T. Baltzer, Thomas H. Helbich, Eleanor Cornford, Patrice Taourel, Vanesa Beslagic, Rubina M. Trimboli, Edward Azavedo, Sylvia H. Heywang-Köbrunner, Markus Müller-Schimpfle, Eugenia C. Lisencu, Francesco Sardanelli, Fiona J. Gilbert, Valentin Ivanov, Natalia Rotaru, Dragana Bogdanovic-Stojanovic, University of Milan, Haukeland University Hospital, Hospital Reina Sofia, Cordoba, Karolinska University Hospital [Stockholm], Meander Medical Center, Département d'imagerie médicale [Gustave Roussy], Institut Gustave Roussy ( IGR ), Medical University of Vienna, Clinical Center University of Sarajevo, Charite-Universitatsmedizin Berlin [Berlin], Institutski put 4, Vilnius University [Vilnius], University Hospital Centre Zagreb and University of Zagreb School of Medicine, Hospital de la Ribera, Centre Hospitalier Lyon Sud [CHU - HCL] ( CHLS ), Hospices Civils de Lyon ( HCL ), Nottingham University Hospitals NHS Trust and University of Nottingham, Computer Science Institute of Charles University [Prague] ( IUUK ), Charles University [Prague], ImageRive, Acibadem University Maslak Hospital, Ninewells Hospital and Medical School [Dundee], Medical University Graz, University of Cambridge [UK] ( CAM ), Mater Misericordiae University Hospital, Tokuda Hospital Sofia, Value Chain, Processing and Aquaculture, Matis Ohf Food Safety Environm & Genet, Landspitalinn University Hospital, Reykjavik, Department of Medicine III, University hospital (UKA), University of Aachen (RWTH), Rheinisch-Westfälische Technische Hochschule Aachen ( RWTH ) -University hospital (UKA), The Oncology Institute 'Prof. Dr. Ion Chiricuta', Radboud University Nijmegen Medical Centre, Nijmegen, University of Coimbra [Portugal] ( UC ), Ghent University Hospital, Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), University of Bergen (UiB), Institut Gustave Roussy (IGR), Medizinische Universität Wien = Medical University of Vienna, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Computer Science Institute of Charles University [Prague] (IUUK), Charles University [Prague] (CU), Acibadem University, University of Cambridge [UK] (CAM), Rheinisch-Westfälische Technische Hochschule Aachen (RWTH)-University hospital (UKA), Radboud University Medical Center [Nijmegen], University of Coimbra [Portugal] (UC), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Sardanelli, Francesco [0000-0001-6545-9427], Apollo - University of Cambridge Repository, and Acibadem University Dspace
- Subjects
digital breast tomosynthesis ,cancer risk ,0302 clinical medicine ,Breast cancer ,Belgium ,Germany ,digital mammography ,middle aged ,vacuum assisted biopsy ,Medicine ,nuclear magnetic resonance imaging ,breast density ,skin and connective tissue diseases ,Finland ,Early Detection of Cancer ,Czech Republic ,education.field_of_study ,Greece ,adult ,General Medicine ,3. Good health ,aged ,Italy ,priority journal ,Radiology Nuclear Medicine and imaging ,030220 oncology & carcinogenesis ,Switzerland ,early diagnosis ,Mammography ,Estonia ,Slovakia ,medicine.medical_specialty ,Digital mammography ,Croatia ,diagnostic imaging ,Article ,03 medical and health sciences ,Digital breast tomosynthesis (DBT) ,radiation induced neoplasm ,Humans ,human ,procedures ,education ,Aged ,Bosnia and Herzegovina ,Sweden ,Hungary ,[ SDV ] Life Sciences [q-bio] ,medicine.disease ,radiology ,cancer screening ,Position paper ,Poland ,Denmark ,[SDV]Life Sciences [q-bio] ,Iceland ,core biopsy ,Turkey (republic) ,030218 nuclear medicine & medical imaging ,cancer mortality ,Population-based screening ,fine needle aspiration biopsy ,organization and management ,Breast MRI ,Mass Screening ,Breast ,Israel ,Overdiagnosis ,Bulgaria ,Netherlands ,early cancer diagnosis ,medicine.diagnostic_test ,Norway ,breast tumor ,Middle Aged ,Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] ,Europe ,female ,Austria ,population-based screening ,recall rate ,nuclear medicine and imaging ,Female ,France ,Radiology ,Serbia ,Adult ,Breast imaging ,Population ,Breast Neoplasms ,Middle East ,breast cancer ,Recall rate ,biopsy ,Radiology, Nuclear Medicine and imaging ,ddc:610 ,Portugal ,Romania ,business.industry ,cost effectiveness analysis ,Lithuania ,Moldova ,Spain ,radiologist ,business ,Ireland - Abstract
Contains fulltext : 177890.pdf (Publisher’s version ) (Open Access) EUSOBI and 30 national breast radiology bodies support mammography for population-based screening, demonstrated to reduce breast cancer (BC) mortality and treatment impact. According to the International Agency for Research on Cancer, the reduction in mortality is 40 % for women aged 50-69 years taking up the invitation while the probability of false-positive needle biopsy is
- Published
- 2017
35. White Paper AGA: Optimal Strategies to Define and Diagnose Gastroesophageal Reflux Disease
- Author
-
Michael F. Vaezi, Marcelo F. Vela, Nicholas J. Shaheen, and John E. Pandolfino
- Subjects
Pediatrics ,medicine.medical_specialty ,Baclofen ,Esophageal pH Monitoring ,Manometry ,Biopsy ,Disease ,Gastroenterology ,Severity of Illness Index ,Endoscopy, Gastrointestinal ,03 medical and health sciences ,0302 clinical medicine ,White paper ,Esophagus ,Internal medicine ,Surveys and Questionnaires ,medicine ,Esophagitis ,Humans ,Patient Reported Outcome Measures ,Esophagogastric junction ,Precision Medicine ,Randomized Controlled Trials as Topic ,Hepatology ,Laryngoscopy ,business.industry ,Muscle Relaxants, Central ,Reflux ,Transcutaneous electric nerve stimulation ,Proton Pump Inhibitors ,medicine.disease ,Hernia, Hiatal ,Phenotype ,030220 oncology & carcinogenesis ,GERD ,Gastroesophageal Reflux ,Transcutaneous Electric Nerve Stimulation ,030211 gastroenterology & hepatology ,Esophagogastric Junction ,business - Published
- 2017
36. ECCO Position Paper: Harmonization of the Approach to Ulcerative Colitis Histopathology
- Author
-
Gert De Hertogh, Magali Svrcek, Roger Feakins, Luc Biedermann, Monika Tripathi, Lieven Pouillon, Vincenzo Villanacci, Laurent Peyrin-Biroulet, Fernando Magro, Michael Scharl, Glen A. Doherty, Francesca Rosini, Silvio Danese, Fátima Carneiro, Alissa Walsh, Paula Borralho, Magro, Fernando, Doherty, Glen, Peyrin-Biroulet, Laurent, Svrcek, Magali, Borralho, Paula, Walsh, Alissa, Carneiro, Fatima, Rosini, Francesca, de Hertogh, Gert, Biedermann, Luc, Pouillon, Lieven, Scharl, Michael, Tripathi, Monika, Danese, Silvio, Villanacci, Vincenzo, Feakins, Roger, and Repositório da Universidade de Lisboa
- Subjects
medicine.medical_specialty ,Clinical trials histology ,Consensus ,Biopsy ,Histopathology ,law.invention ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Humans ,Colitis ,Intestinal Mucosa ,ulcerative colitis ,medicine.diagnostic_test ,business.industry ,Histological Techniques ,Remission Induction ,Gastroenterology ,Patient Acuity ,Histology ,General Medicine ,Colonoscopy ,Reference Standards ,medicine.disease ,Prognosis ,Ulcerative colitis ,Endoscopy ,Europe ,Treatment Outcome ,histopathology ,Observational study ,Colitis, Ulcerative ,business - Abstract
© The Author(s) 2020. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)., Currently, the main targets of drug therapy for ulcerative colitis [UC] are endoscopic and clinical remission. However, there is active discussion about the additional advantages of including histological remission as a target. Accumulating evidence indicates that microscopic activity persists in endoscopically quiescent UC, that histological changes may lag behind clinical remission after treatment, and that absence of histological activity predicts lower rates of relapse, hospitalization, surgery and subsequent neoplasia. Obtaining useful information from mucosal biopsies in this setting depends on accurate and consistent evaluation of histological features. However, there is no standardization of biopsy procedures, histological sample processing technique or histological scoring systems, and there is no agreement on the definitions of histological remission, response or activity. Accordingly, a consensus expert panel convened by the European Crohn's and Colitis Organisation [ECCO] reviewed the literature and agreed a number of position statements regarding harmonization of UC histopathology. The objective was to provide evidence-based guidance for the standardization and harmonization of procedures, definitions and scoring systems for histology in UC, and to reach expert consensus where possible. We propose the absence of intraepithelial neutrophils, erosion and ulceration as a minimum requirement for the definition of histological remission. For randomized control trials we recommend the use of the Robarts histopathology index [RHI] or the Nancy index [NI]. For observational studies or in clinical practice we recommend the use of the NI. To predict the risk of future neoplasia in UC, cumulative histological scores over time are more useful than single scores.
- Published
- 2020
37. A British Society for haematology good practice paper on the diagnosis and investigation of patients with mantle cell lymphoma
- Author
-
Bob Jackson, Pamela McKay, Simon Rule, Stephen Robinson, and Mike Leach
- Subjects
medicine.medical_specialty ,Biopsy ,Lymphoma, Mantle-Cell ,Central Nervous System Neoplasms ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Positron Emission Tomography Computed Tomography ,Internal medicine ,medicine ,Humans ,Good practice ,Neoplasm Staging ,PET-CT ,Hematology ,business.industry ,Molecular pathology ,Professional Practice ,Prognosis ,medicine.disease ,030220 oncology & carcinogenesis ,Mantle cell lymphoma ,Radiology ,business ,030215 immunology - Published
- 2018
38. An Update of the American Urological Association White Paper on the Prevention and Treatment of the More Common Complications Related to Prostate Biopsy
- Author
-
Maxwell V. Meng, Sean P. Stroup, Vanessa Spears, Jay D. Raman, Michael A. Liss, Behfar Ehdaie, and Stacy Loeb
- Subjects
Male ,medicine.medical_specialty ,Prostate biopsy ,Biopsy ,Urology ,030232 urology & nephrology ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Prostate ,medicine ,Humans ,Needle Tract Seeding ,Antibiotic prophylaxis ,medicine.diagnostic_test ,Urinary retention ,business.industry ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Erectile dysfunction ,030220 oncology & carcinogenesis ,medicine.symptom ,Complication ,business - Abstract
In this white paper update we identify and discuss the prevalence and prevention of common complications of prostate needle biopsy.A literature review was performed on prostate biopsy complications via queries of PubMed and EMBASEInfection is the most common complication of prostate biopsy with fluoroquinolone resistant Escherichia coli having a prominent role. Reported rates of infectious complications range from 0.1% to 7.0%, and sepsis rates range from 0.3% to 3.1% depending on antibiotic prophylaxis regimens. Mild, self-limiting and transient bleeding is also a common complication. Other complications are extremely rare.This white paper provides a concise reference document for the more common prostate biopsy complications and prevention strategies. Risk assessment should be performed for all patients to identify known risk factors for harboring fluoroquinolone resistance. If infection incidence increases check the local antibiogram, current equipment and cleaning practices, and consider alternate approaches to antibiotic prevention such as needle cleaning, risk basked augmentation, rectal culture with targeted prophylaxis and transperineal biopsy. If infection occurs, actively re-situate the patient and start empiric intravenous treatment with carbapenems, amikacin or second and third generation cephalosporins.
- Published
- 2017
39. Liver biopsy in children: position paper of the ESPGHAN Hepatology Committee
- Author
-
Ozlem Durmaz, Pietro Vajro, Nedim Hadzic, Valérie A. McLin, Ulrich Baumann, Anil Dhawan, F. Lacaille, Björn Fischler, Piotr Socha, Valerio Nobili, Antal Dezsőfi, Loreto Hierro, and A.S. Knisely
- Subjects
medicine.medical_specialty ,Nutritional Sciences ,Biopsy ,MEDLINE ,Histopathological examination ,Pediatrics ,Liver disease ,Internal medicine ,medicine ,Humans ,Precision Medicine ,Intensive care medicine ,Child ,Societies, Medical ,ddc:618 ,Evidence-Based Medicine ,medicine.diagnostic_test ,business.industry ,Contraindications ,Liver Diseases ,Gastroenterology ,Infant, Newborn ,Infant ,Evidence-based medicine ,Hepatology ,Precision medicine ,medicine.disease ,Prognosis ,Surgery ,Europe ,Liver ,Liver biopsy ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Position paper ,business - Abstract
Liver biopsy (LB) is still the criterion standard procedure for obtaining liver tissue for histopathological examination and a valuable tool in the diagnosis, prognosis, and management of many parenchymal liver diseases. The aim of this position paper is to summarise the present practice of paediatric LB and make recommendations about its performance. Although histological evaluation of the liver is important in assessing prognosis and exploring treatment, noninvasive techniques (ie, imaging, laboratory markers) may replace use of liver histology. The indications for LB are changing as present knowledge of aetiologies, pathomechanism, and therapeutic options in paediatric liver disease is evolving. Adult and paediatric literature was reviewed to assess the existing clinical practice of LB with focus on the technique, indications, risk of complications, and contraindications in paediatrics. This position paper presents types of LB, indications, complications, contraindications, and an essential checklist for paediatric LB.
- Published
- 2014
40. White Paper: Interventional MRI: Current Status and Potential for Development Considering Economic Perspectives, Part 2: Liver and Other Applications in Oncology
- Author
-
Jörg, Barkhausen, Thomas, Kahn, Gabriele A, Krombach, Christiane K, Kuhl, Joachim, Lotz, David, Maintz, Jens, Ricke, Stefan O, Schönberg, Thomas J, Vogl, Frank K, Wacker, and F K, Wacker
- Subjects
medicine.medical_specialty ,Remote patient monitoring ,Interventional magnetic resonance imaging ,medicine.medical_treatment ,Magnetic Resonance Imaging, Interventional ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Germany ,Neoplasms ,Biopsy ,medicine ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Reimbursement ,Modalities ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Image Enhancement ,Ablation ,3. Good health ,Soft tissue contrast ,Surgery, Computer-Assisted ,030220 oncology & carcinogenesis ,Radiology ,business ,Forecasting - Abstract
Background MRI is attractive for guiding and monitoring interventional procedures due to its high intrinsic soft tissue contrast and the possibility to measure flow and cardiac function. Methods Technical solutions have been developed for all procedural steps including imaging guidance, MR-safe catheters and instruments and patient monitoring. This has led to widening of the clinical applications. Interventional MRI is becoming increasingly important for the treatment of patients suffering from malignant diseases. The detectability of masses and consequently their accessibility for biopsy is higher, compared to other modalities, due to the high intrinsic soft tissue contrast of MRI. Temperature-dependent sequences allow for minimally invasive and tissue-sparing ablation (A-0 ablation). Conclusion Interventional MRI has become established in the clinical routine for a variety of indications, including biopsies and tumor ablation. Since the economic requirement of covering costs by reimbursement is met and interventional MRI decreases the mortality and morbidity of interventional procedures, broader application of interventional MRI can be expected in the clinical routine in the future. Key points Citation Format
- Published
- 2017
41. White Paper: Interventional MRI: Current Status and Potential for Development Considering Economic Perspectives, Part 1: General Application
- Author
-
Jörg, Barkhausen, Thomas, Kahn, Gabriele A, Krombach, Christiane K, Kuhl, Joachim, Lotz, David, Maintz, Jens, Ricke, Stefan O, Schönberg, Thomas J, Vogl, Frank K, Wacker, and F K, Wacker
- Subjects
Ablation Techniques ,medicine.medical_specialty ,National Health Programs ,Interventional magnetic resonance imaging ,Biopsy ,Cost-Benefit Analysis ,030204 cardiovascular system & hematology ,Magnetic Resonance Imaging, Interventional ,030218 nuclear medicine & medical imaging ,Translational Research, Biomedical ,03 medical and health sciences ,0302 clinical medicine ,Germany ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Neuronavigation ,Modalities ,medicine.diagnostic_test ,business.industry ,Endovascular Procedures ,Ultrasound ,Monitoring system ,Clinical routine ,3. Good health ,Soft tissue contrast ,Surgery, Computer-Assisted ,Radiology ,Mr images ,business - Abstract
Background MRI is attractive for the guiding and monitoring of interventional procedures due to its high intrinsic soft tissue contrast and the possibility to measure physiologic parameters like flow and cardiac function. Method The current status of interventional MRI for the clinical routine was analyzed. Results The effort needed for the development of MR-safe monitoring systems and instruments initially resulted in the application of interventional MRI only for procedures that could not be performed by other means. Accordingly, biopsy of lesions in the breast, which are not detectable by other modalities, has been performed under MRI guidance for decades. Currently, biopsies of the prostate under MRI guidance are established in a similar fashion. At many sites blind biopsy has already been replaced by MR-guided biopsy or at least by the fusion of MR images with ultrasound. Cardiovascular interventions are performed at several centers for ablation as a treatment for atrial fibrillation. Conclusion Interventional MRI has been established in the clinical routine for a variety of indications. Broader application can be expected in the clinical routine in the future owing to the multiple advantages compared to other techniques. Key points Citation format
- Published
- 2017
42. ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee
- Author
-
Ulrike M. Hamper, William D. Middleton, Franklin N. Tessler, Carl C. Reading, Jill E. Langer, A. Thomas Stavros, Terry S. Desser, Lynwood Hammers, Michael D. Beland, Edward Grant, Jenny K. Hoang, Leslie M. Scoutt, Sharlene A. Teefey, Lincoln L. Berland, Mary C. Frates, and John J. Cronan
- Subjects
Thyroid nodules ,medicine.medical_specialty ,medicine.diagnostic_test ,Breast imaging ,business.industry ,Thyroid ,MEDLINE ,medicine.disease ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Biopsy ,Risk stratification ,medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,Ultrasonography ,business ,Thyroid cancer - Abstract
Thyroid nodules are a frequent finding on neck sonography. Most nodules are benign; therefore, many nodules are biopsied to identify the small number that are malignant or require surgery for a definitive diagnosis. Since 2009, many professional societies and investigators have proposed ultrasound-based risk stratification systems to identify nodules that warrant biopsy or sonographic follow-up. Because some of these systems were founded on the BI-RADS® classification that is widely used in breast imaging, their authors chose to apply the acronym TI-RADS, for Thyroid Imaging, Reporting and Data System. In 2012, the ACR convened committees to (1) provide recommendations for reporting incidental thyroid nodules, (2) develop a set of standard terms (lexicon) for ultrasound reporting, and (3) propose a TI-RADS on the basis of the lexicon. The committees published the results of the first two efforts in 2015. In this article, the authors present the ACR TI-RADS Committee's recommendations, which provide guidance regarding management of thyroid nodules on the basis of their ultrasound appearance. The authors also describe the committee's future directions.
- Published
- 2017
43. The BMJ Awards 2019: UK Research Paper of the Year
- Author
-
Jacqui Wise
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Suspected prostate cancer ,General Medicine ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,03 medical and health sciences ,0302 clinical medicine ,Biopsy ,medicine ,Transrectal ultrasonography ,030212 general & internal medicine ,Radiology ,Prostate gland ,business ,Raised prostate specific antigen - Abstract
For the past 25 years, men with suspected prostate cancer on the basis of a raised prostate specific antigen (PSA) test have typically been offered standard transrectal ultrasonography (TRUS) guided biopsy of the prostate gland. However, this approach sometimes misses clinically significant tumours and can lead to the over-detection of low grade cancers. The PRECISION trial1 was one of the first multicentre …
- Published
- 2019
44. Chronic atrophic gastritis. Natural history, diagnosis and therapeutic management. A position paper by the Italian Society of Hospital Gastroenterologists and Digestive Endoscopists [AIGO], the Italian Society of Digestive Endoscopy [SIED], the Italian Society of Gastroenterology [SIGE], and the Italian Society of Internal Medicine [SIMI]
- Author
-
Paola Cesaro, Marco Vincenzo Lenti, Bruno Annibale, Gino Roberto Corazza, Antonio Di Sabatino, Alberto Meggio, Rocco Maurizio Zagari, Angelo Zullo, Edith Lahner, Lahner E., Zagari R.M., Zullo A., Di Sabatino A., Meggio A., Cesaro P., Lenti M.V., Annibale B., and Corazza G.R.
- Subjects
Gastritis, Atrophic ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Atrophic gastritis ,Autoimmune Gastritis ,diagnosis ,Biopsy ,autoimmune gastritis ,h. pylori ,Gastroenterology ,Endoscopy, Gastrointestinal ,Autoimmune Diseases ,Helicobacter Infections ,Atrophic gastriti ,Autoimmune thyroiditis ,histology ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,atrophic gastritis ,Humans ,Medicine ,Helicobacter ,Vitamin B ,Type 1 diabetes ,Hepatology ,biology ,business.industry ,Intestinal metaplasia ,Cancer ,Autoimmune gastriti ,medicine.disease ,biology.organism_classification ,Patient Care Management ,Natural history ,Italy ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,vitamin b 12 ,Deficiency Diseases ,business ,Diagnosi - Abstract
Chronic atrophic gastritis (CAG) is an underdiagnosed condition characterised by translational features going beyond the strict field of gastroenterology as it may manifest itself by a variable spectrum of gastric and extra-gastric symptoms and signs. It is relatively common among older adults in different parts of the world, but large variations exist. Helicobacter pylori-related CAG [multifocal] and autoimmune CAG (corpus-restricted) are apparently two different diseases, but they display overlapping features. Patients with cobalamin and/or iron deficiency anaemia or autoimmune disorders, including autoimmune thyroiditis and type 1 diabetes mellitus, should be offered screening for CAG. Pepsinogens, gastrin-17, and anti-H. pylori antibodies serum assays seem to be reliable non-invasive screening tools for the presence of CAG, helpful to identify individuals to refer to gastroscopy with five standard gastric biopsies in order to obtain histological confirmation of diagnosis. Patients with CAG are at increased risk of developing gastric cancer, and they should be estimated with histological staging systems (OLGA or OLGIM). H. pylori eradication may be beneficial by modifying the natural history of atrophy, but not that of intestinal metaplasia. Patients with advanced stages of CAG (Stage III/IV OLGA or OLGIM) should undergo endoscopic surveillance every three years, those with autoimmune CAG every three-five years. In patients with CAG, a screening for autoimmune thyroid disease and micronutrient deficiencies, including iron and vitamin B12, should be performed. The optimal treatment for dyspeptic symptoms in patients with CAG remains to be defined. Proton pump inhibitors are not indicated in hypochlorhydric CAG patients.
- Published
- 2019
45. Duplex qPCR for Leishmania species identification using lesion imprint on filter paper
- Author
-
Maria Edileuza Felinto de Brito, Rômulo Freire de Morais, Tayná Correia de Goes, Milena de Paiva Cavalcanti, Sinval Pinto Brandão-Filho, Rômulo Pessoa e Silva, Maria Gabriella Nunes de Melo, Jorge Augusto de Oliveira Guerra, and Rayana Carla Silva de Morais
- Subjects
Trypanosoma cruzi ,In silico ,Immunology ,Leishmaniasis, Cutaneous ,Biology ,Sensitivity and Specificity ,Lesion ,Cutaneous leishmaniasis ,Predictive Value of Tests ,DNA, Ribosomal Spacer ,Biopsy ,medicine ,TaqMan ,Humans ,HSP70 Heat-Shock Proteins ,Internal transcribed spacer ,Leishmania ,medicine.diagnostic_test ,Exons ,General Medicine ,DNA, Protozoan ,medicine.disease ,Molecular biology ,Infectious Diseases ,Real-time polymerase chain reaction ,Case-Control Studies ,GenBank ,Parasitology ,medicine.symptom ,Multiplex Polymerase Chain Reaction ,Filtration ,Multilocus Sequence Typing - Abstract
American cutaneous leishmaniasis (ACL) is caused by different Leishmania parasites, which stimulate and direct the immune response against the infection.To evaluate the TaqMan probe technology applicability to diagnose and identifying of Leishmania spp. related to the ACL etiology.Through the MEGA 6.0 software, performed an in silico analysis using multiple alignments of Leishmania spp. which were available on GenBank for different genomic targets. The efficiency (e), specificity and detection limit (DL) were calculated for each system, these were associated to compose a duplex-qPCR (DqPCR). The samples of blood, lesion biopsy and lesion imprint on filter paper from patients residing in states of Amazonas (AM) and Pernambuco (PE)-Brazil, (cases and controls) were used to perform the DqPCR technique. The capacity to identify the Leishmania species was determined by comparison with isoenzymes method and sequencing analysis.Internal Transcribed Spacer 1 (rDNA) was the target selected. Two sets of primers and probes were designed and combined: SVS for subgenus Viannia and LaS for L. (L.) amazonensis. The results were: SVSe = 93.24%, SVS DL = 50 fg/μL; LaSe = 89.3%, LaSLD = 5 fg/μL presented 100% of specificity. In total, 236 individuals participated of the present study, wherein were 101 blood samples, 33 biopsies and 147 lesion imprints. The imprint was the most sensitive sample, showing 83.06% of sensitivity, 86.96% of specificity and substantial agreement between the techniques analysis (k = 0.531; p 0,001). Regarding the species identification, DqPCR and sequencing/isoenzymes have agreed at 100%, since the infection is caused by a single Leishmania species.The DqPCR technique was applicable in diagnosis and identification of Leishmania spp. (subgenus Viannia and L. amazonensis). Furthermore, the lesion imprint is less invasive, allowing a fewer discomfort and greater acceptance by the patients, in addition of being low cost and easy handling.
- Published
- 2020
46. Clinical approach to the management of Intestinal Failure Associated Liver Disease (IFALD) in adults: A position paper from the Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN
- Author
-
Geert J. A. Wanten, Federico Bozzetti, André Van Gossum, Jann Arends, Darlene G. Kelly, Cristina Cuerda, Stéphane M. Schneider, Francisca Joly, Kinga Szczepanek, Simon Lal, Michael Staun, Loris Pironi, Lal, Simon, Pironi, Lori, Wanten, Geert, Arends, Jann, Bozzetti, Federico, Cuerda, Cristina, Joly, Francisca, Kelly, Darlene, Staun, Michael, Szczepanek, Kinga, Van Gossum, Andre, and Schneider, Stephane Michel
- Subjects
Adult ,0301 basic medicine ,medicine.medical_specialty ,Biopsy ,medicine.medical_treatment ,Autoimmune hepatitis ,Liver transplantation ,Critical Care and Intensive Care Medicine ,Chronic liver disease ,Gastroenterology ,03 medical and health sciences ,Liver disease ,Enteral Nutrition ,0302 clinical medicine ,Liver Function Tests ,Cholestasis ,Sepsis ,Internal medicine ,Nutrition and Dietetic ,medicine ,Humans ,Societies, Medical ,Hyperbilirubinemia ,030109 nutrition & dietetics ,Nutrition and Dietetics ,medicine.diagnostic_test ,business.industry ,Liver Diseases ,Intestinal failure associated liver disease (IFALD) ,Bilirubin ,Intestinal failure ,Parenteral nutrition ,medicine.disease ,Lipids ,Chronic intestinal failure ,Europe ,Intestinal Diseases ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,Liver ,Liver biopsy ,Abnormal Liver Function Test ,030211 gastroenterology & hepatology ,Nutrition Therapy ,business - Abstract
Item does not contain fulltext We recommend that intestinal failure associated liver disease (IFALD) should be diagnosed by the presence of abnormal liver function tests and/or evidence of radiological and/or histological liver abnormalities occurring in an individual with IF, in the absence of another primary parenchymal liver pathology (e.g. viral or autoimmune hepatitis), other hepatotoxic factors (e.g. alcohol/medication) or biliary obstruction. The presence or absence of sepsis should be noted, along with the duration of PN administration. Abnormal liver histology is not mandatory for a diagnosis of IFALD and the decision to perform a liver biopsy should be made on a case-by-case basis, but should be particularly considered in those with a persistent abnormal conjugated bilirubin in the absence of intra or extra-hepatic cholestasis on radiological imaging and/or persistent or worsening hyperbilirubinaemia despite resolution of any underlying sepsis and/or any clinical or radiological features of chronic liver disease. Nutritional approaches aimed at minimising PN overfeeding and optimising oral/enteral nutrition should be instituted to prevent and/or manage IFALD. We further recommend that the lipid administered is limited to less than 1 g/kg/day, and the prescribed omega-6/omega-3 PUFA ratio is reduced wherever possible. For patients with any evidence of progressive hepatic fibrosis or overt liver failure, combined intestinal and liver transplantation should be considered.
- Published
- 2018
47. Yesterday's News is Today's Fish and Chip Paper.
- Author
-
Tree, A.C.
- Subjects
- *
PROSTATE tumors treatment , *BIOPSY , *METASTASIS , *PROSTATECTOMY , *RADIOTHERAPY , *SERIAL publications , *GENOMICS - Published
- 2020
- Full Text
- View/download PDF
48. Position paper: The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction
- Author
-
Alex J, Thompson, Michael, Hughes, Salzitsa, Anastasova, Laurie S, Conklin, Tudor, Thomas, Cadman, Leggett, William A, Faubion, Thomas J, Miller, Peter, Delaney, François, Lacombe, Sacha, Loiseau, Alexander, Meining, Rebecca, Richards-Kortum, Guillermo J, Tearney, Paul, Kelly, and Guang-Zhong, Yang
- Subjects
Photoacoustic Techniques ,Intestinal Diseases ,Spectrometry, Fluorescence ,Malabsorption Syndromes ,Biopsy ,Intestine, Small ,Optical Imaging ,Humans ,Environmental Exposure ,Tomography, Optical Coherence - Abstract
Environmental enteric dysfunction (EED) is a disease of the small intestine affecting children and adults in low and middle income countries. Arising as a consequence of repeated infections, gut inflammation results in impaired intestinal absorptive and barrier function, leading to poor nutrient uptake and ultimately to stunting and other developmental limitations. Progress towards new biomarkers and interventions for EED is hampered by the practical and ethical difficulties of cross-validation with the gold standard of biopsy and histology. Optical biopsy techniques - which can provide minimally invasive or noninvasive alternatives to biopsy - could offer other routes to validation and could potentially be used as point-of-care tests among the general population. This Consensus Statement identifies and reviews the most promising candidate optical biopsy technologies for applications in EED, critically assesses them against criteria identified for successful deployment in developing world settings, and proposes further lines of enquiry. Importantly, many of the techniques discussed could also be adapted to monitor the impaired intestinal barrier in other settings such as IBD, autoimmune enteropathies, coeliac disease, graft-versus-host disease, small intestinal transplantation or critical care.
- Published
- 2017
49. Bone Biopsy Practice Patterns Across Europe: the European Renal Osteodystrophy Initiative - a Position Paper
- Author
-
Aníbal Ferreira, Pieter Evenepoel, Patrick C. D'Haese, Mathias Haarhaus, Syazrah Salam, Goce Spasovski, Jorge B. Cannata-Andía, Mario Cozzolino, Sandro Mazzaferro, Marie-Helene Lafage Proust, Justine Bacchetta, and ERA-EDTA Working Group on CKD-MBD
- Subjects
medicine.medical_specialty ,biomarkers ,bone mineral density ,chronic renal failure ,hyperparathyroidism ,renal osteodystrophy ,genetic structures ,Biopsy ,030232 urology & nephrology ,030209 endocrinology & metabolism ,urologic and male genital diseases ,Bone and Bones ,Bone remodeling ,03 medical and health sciences ,0302 clinical medicine ,Chronic kidney disease-mineral and bone disorder ,Epidemiology ,medicine ,Humans ,Renal osteodystrophy ,Practice Patterns, Physicians' ,Intensive care medicine ,Chronic Kidney Disease-Mineral and Bone Disorder ,Transplantation ,Hyperparathyroidism ,medicine.diagnostic_test ,business.industry ,Pharmacology. Therapy ,HCC NEF ,medicine.disease ,Surgery ,Europe ,Clinical research ,Nephrology ,Human medicine ,business ,Kidney disease - Abstract
Renal osteodystrophy (ROD) is a heterogeneous group of metabolic bone diseases complicating progressive chronic kidney disease (CKD). Bone biomarkers and bone imaging techniques may help to assess bone health and predict fractures in CKD but do have important inherent limitations. By informing on bone turnover and mineralization, a bone biopsy may help to guide prevention and treatment of ROD and its consequences. According to a recent survey conducted among European nephrologists, bone biopsies are performed rather exceptionally, both for clinical and research purposes. Obviously, clinical research in the field of ROD is threatened by vanishing clinical and pathological expertise, small patient cohorts and scientific isolation. In March 2016, the European Renal Osteodystrophy (EU-ROD) initiative was created under the umbrella of the ERA-EDTA CKD-mineral and bone disorder (MBD) Working Group to revitalize bone biopsy as a clinically useful tool in the diagnostic workup of CKD-MBD and to foster research on the epidemiology, implications and reversibility of ROD. As such, the EU-ROD initiative aims to increase the understanding of ROD and ultimately to improve outcomes in CKD patients. info:eu-repo/semantics/publishedVersion
- Published
- 2017
50. Role of Liver Biopsy in Assessment of Radiologically Identified Liver Masses.
- Author
-
Khalifa A, Sasso R, and Rockey DC
- Subjects
- Diagnosis, Differential, Female, Humans, Male, Middle Aged, Reproducibility of Results, Retrospective Studies, Tomography, X-Ray Computed methods, United States, Biopsy methods, Granuloma diagnosis, Liver diagnostic imaging, Liver pathology, Liver Cirrhosis diagnosis, Liver Neoplasms diagnostic imaging, Liver Neoplasms pathology, Neoplasm Metastasis diagnostic imaging, Neoplasm Metastasis pathology
- Abstract
Background: Despite improvements in imaging techniques that have enhanced the ability to diagnose hepatocellular carcinoma (HCC), histopathological evaluation of many other types of liver masses is critical., Aims: To evaluate the utility of liver biopsy in patients with radiologically undiagnosed liver masses., Methods: We retrospectively analyzed 293 consecutive patients who had a liver biopsy for evaluation of an undiagnosed liver mass between January 2014 and January 2018., Results: Out of 293 biopsies, 246 patients were found to have malignancy (84%), including 210 (72%) patients with metastatic malignancy and 36 with primary hepatic malignancies (20 HCC and 16 others). In the 47 patients without malignancy, 17 patients had necrotic abscess/granuloma, 16 patients had normal histology, eight patients had hepatic fibrosis/cirrhosis without malignant foci, and six patients had benign tumors. The most common primary lesion in patients with liver metastasis was breast carcinoma (32/293, 11%), followed by colon and pancreas (31 (each)/293, 11%), and lung (9%) adenocarcinomas. Histopathological analysis confirmed the presence of metastasis in 165/200 (83%) patients with a history of oncological malignancy and in 45/93 (48%) patients who had no malignancy history., Conclusions: In patients with a radiologically identified liver mass of unclear etiology, liver biopsy/histology made a diagnosis in 95% (277/293) of patients, including 84% (246/293) found to have an oncological malignancy. Liver biopsy/histology also identified malignancy in a high proportion of patients without known underlying cancer. We conclude that liver biopsy is valuable for evaluation of radiologically identified liver masses of unclear etiology., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.)
- Published
- 2022
- Full Text
- View/download PDF
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.