7 results
Search Results
2. Estimates of regional infectivity of COVID-19 in the United Kingdom following imposition of social distancing measures.
- Author
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Challen, Robert, Tsaneva-Atanasova, Krasimira, Pitt, Martin, Edwards, Tom, Gompels, Luke, Lacasa, Lucas, Brooks-Pollock, Ellen, and Danon, Leon
- Subjects
- *
COVID-19 , *SOCIAL distancing , *SARS-CoV-2 , *INFECTIOUS disease transmission , *BASIC reproduction number - Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reproduction number has become an essential parameter for monitoring disease transmission across settings and guiding interventions. The UK published weekly estimates of the reproduction number in the UK starting in May 2020 which are formed from multiple independent estimates. In this paper, we describe methods used to estimate the time-varying SARSCoV-2 reproduction number for the UK. We used multiple data sources and estimated a serial interval distribution from published studies. We describe regional variability and how estimates evolved during the early phases of the outbreak, until the relaxing of social distancing measures began to be introduced in early July. Our analysis is able to guide localized control and provides a longitudinal example of applying these methods over long timescales. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
3. Seasonal variation in airborne infection risk in schools due to changes in ventilation inferred from monitored carbon dioxide.
- Author
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Vouriot, Carolanne V. M., Burridge, Henry C., Noakes, Catherine J., and Linden, Paul F.
- Subjects
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AIRBORNE infection , *SEASONS , *COVID-19 pandemic , *CARBON dioxide , *MICROBIOLOGICAL aerosols , *INFECTIOUS disease transmission , *COVID-19 - Abstract
The year 2020 has seen the world gripped by the effects of the COVID‐19 pandemic. It is not the first time, nor will it be last, that our increasingly globalized world has been significantly affected by the emergence of a new disease. In much of the Northern Hemisphere, the academic year begins in September, and for many countries, September 2020 marked the return to full schooling after some period of enforced closure due to COVID‐19. In this paper, we focus on the airborne spread of disease and investigate the likelihood of transmission in school environments. It is crucial to understand the risk airborne infection from COVID‐19 might pose to pupils, teachers, and their wider social groups. We use monitored CO2 data from 45 classrooms in 11 different schools from within the UK to estimate the likelihood of infection occurring within classrooms regularly attended by the same staff and pupils. We determine estimates of the number of secondary infections arising via the airborne route over pre/asymptomatic periods on a rolling basis. Results show that, assuming relatively quiet desk‐based work, the number of secondary infections is likely to remain reassuringly below unity; however, it can vary widely between classrooms of the same school even when the same ventilation system is present. Crucially, the data highlight significant variation with the seasons with January being nearly twice as risky as July. We show that such seasonal variations in risk due to changes in ventilation rates are robust and our results hold for wide variations in disease parameterizations, suggesting our results may be applied to a number of different airborne diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
4. A Bayesian risk assessment of the COVID-19 pandemic using FMEA and a modified SEIR epidemic model.
- Author
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Yang, QingPing and Koucha, Yacine
- Subjects
- *
COVID-19 pandemic , *PANDEMICS , *FAILURE mode & effects analysis , *COVID-19 , *INFECTIOUS disease transmission , *RISK assessment , *EPIDEMICS , *REPRODUCTION - Abstract
The COVID-19 outbreak is of great concern due to the high rates of infection and the large number of deaths worldwide. In this paper, we considered a Bayesian inference and failure mode and effects analysis of the modified susceptible-exposed-infectious-removed model for the transmission dynamics of COVID-19 with an exponentially distributed infectious period. We estimated the effective reproduction number based on laboratory-confirmed cases and death data using Bayesian inference and analyse the impact of the community spread of COVID-19 across the United Kingdom. We used the failure mode and effects analysis tool to evaluate the effectiveness of the action measures taken to manage the COVID-19 pandemic. We focused on COVID-19 infections and therefore the failure mode is taken as positive cases. The model is applied to COVID-19 data showing the effectiveness of interventions adopted to control the epidemic by reducing the reproduction number of COVID-19. Results have shown that the combination of Bayesian inference, compartmental modelling and failure mode and effects analysis is effective in modelling and studying the risks of COVID-19 transmissions, leading to the quantitative evaluation of the action measures and the identification of the lessons learned from the governmental measures and actions taken in response to COVID-19 in the United Kingdom. Analytical and numerical methods are used to highlight the practical implications of our findings. The proposed methodology will find applications in current and future COVID-19 like pandemics and wide quality engineering. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
5. A Bayesian risk assessment of the COVID-19 pandemic using FMEA and a modified SEIR epidemic model.
- Author
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Yang, QingPing and Koucha, Yacine
- Subjects
- *
COVID-19 pandemic , *PANDEMICS , *FAILURE mode & effects analysis , *COVID-19 , *INFECTIOUS disease transmission , *RISK assessment , *EPIDEMICS , *REPRODUCTION - Abstract
The COVID-19 outbreak is of great concern due to the high rates of infection and the large number of deaths worldwide. In this paper, we considered a Bayesian inference and failure mode and effects analysis of the modified susceptible-exposed-infectious-removed model for the transmission dynamics of COVID-19 with an exponentially distributed infectious period. We estimated the effective reproduction number based on laboratory-confirmed cases and death data using Bayesian inference and analyse the impact of the community spread of COVID-19 across the United Kingdom. We used the failure mode and effects analysis tool to evaluate the effectiveness of the action measures taken to manage the COVID-19 pandemic. We focused on COVID-19 infections and therefore the failure mode is taken as positive cases. The model is applied to COVID-19 data showing the effectiveness of interventions adopted to control the epidemic by reducing the reproduction number of COVID-19. Results have shown that the combination of Bayesian inference, compartmental modelling and failure mode and effects analysis is effective in modelling and studying the risks of COVID-19 transmissions, leading to the quantitative evaluation of the action measures and the identification of the lessons learned from the governmental measures and actions taken in response to COVID-19 in the United Kingdom. Analytical and numerical methods are used to highlight the practical implications of our findings. The proposed methodology will find applications in current and future COVID-19 like pandemics and wide quality engineering. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
6. A Bayesian risk assessment of the COVID-19 pandemic using FMEA and a modified SEIR epidemic model.
- Author
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Koucha, Yacine and Yang, QingPing
- Subjects
- *
PANDEMICS , *FAILURE mode & effects analysis , *COVID-19 pandemic , *INFECTIOUS disease transmission , *COVID-19 , *EPIDEMICS , *RISK assessment , *REPRODUCTION - Abstract
The COVID-19 outbreak is of great concern due to the high rates of infection and the large number of deaths worldwide. In this paper, we considered a Bayesian inference and failure mode and effects analysis of the modified susceptible-exposed-infectious-removed model for the transmission dynamics of COVID-19 with an exponentially distributed infectious period. We estimated the effective reproduction number based on laboratory-confirmed cases and death data using Bayesian inference and analyse the impact of the community spread of COVID-19 across the United Kingdom. We used the failure mode and effects analysis tool to evaluate the effectiveness of the action measures taken to manage the COVID-19 pandemic. We focused on COVID-19 infections and therefore the failure mode is taken as positive cases. The model is applied to COVID-19 data showing the effectiveness of interventions adopted to control the epidemic by reducing the reproduction number of COVID-19. Results have shown that the combination of Bayesian inference, compartmental modelling and failure mode and effects analysis is effective in modelling and studying the risks of COVID-19 transmissions, leading to the quantitative evaluation of the action measures and the identification of the lessons learned from the governmental measures and actions taken in response to COVID-19 in the United Kingdom. Analytical and numerical methods are used to highlight the practical implications of our findings. The proposed methodology will find applications in current and future COVID-19 like pandemics and wide quality engineering. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
7. SARS-CoV-2 (COVID-19): What Do We Know About Children? A Systematic Review.
- Author
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Mehta, Nisha S, Mytton, Oliver T, Mullins, Edward W S, Fowler, Tom A, Falconer, Catherine L, Murphy, Orla B, Langenberg, Claudia, Jayatunga, Wikum J P, Eddy, Danielle H, and Nguyen-Van-Tam, Jonathan S
- Subjects
- *
INFECTIOUS disease transmission , *DISEASE susceptibility , *HEALTH , *MEDICAL practice , *PEDIATRICS , *PROFESSIONS , *PUBLIC health administration , *INFORMATION resources , *SYSTEMATIC reviews , *COVID-19 , *CHILDREN - Abstract
Background Few pediatric cases of coronavirus disease 2019 (COVID-19) have been reported and we know little about the epidemiology in children, although more is known about other coronaviruses. We aimed to understand the infection rate, clinical presentation, clinical outcomes, and transmission dynamics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in order to inform clinical and public health measures. Methods We undertook a rapid systematic review and narrative synthesis of all literature relating to SARS-CoV-2 in pediatric populations. The search terms also included SARS-CoV and MERS-CoV. We searched 3 databases and the COVID-19 resource centers of 11 major journals and publishers. English abstracts of Chinese-language papers were included. Data were extracted and narrative syntheses conducted. Results Twenty-four studies relating to COVID-19 were included in the review. Children appear to be less affected by COVID-19 than adults by observed rate of cases in large epidemiological studies. Limited data on attack rate indicate that children are just as susceptible to infection. Data on clinical outcomes are scarce but include several reports of asymptomatic infection and a milder course of disease in young children, although radiological abnormalities are noted. Severe cases are not reported in detail and there are few data relating to transmission. Conclusions Children appear to have a low observed case rate of COVID-19 but may have rates similar to adults of infection with SARS-CoV-2. This discrepancy may be because children are asymptomatic or too mildly infected to draw medical attention and be tested and counted in observed cases of COVID-19. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
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